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Åke Lernmark

Principal investigator

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Effects of ginkgolide b, a platelet-activating factor inhibitor on insulitis in the spontaneously diabetic bb rat

Author

  • Jill C. Beck
  • Charles J. Goodner
  • Cindy Wilson
  • Deborah Wilson
  • Dave Glidden
  • Denis G. Baskin
  • Åke Lernmark
  • Pierre Braquet

Summary, in English

The BB rat spontaneously develops insulin-dependent diabetes mellitus (IDDM) in association with marked insulitis in the islets of Langerhans. Since platelet-activating factor (PAF-acether) is involved in allergic and inflammatory reactions, we tested a PAF antagonist, Ginkgolide B (BN 52021) for potential effects on islet inflammation and diabetes. Diabetes prone BB/Wor rats were treated daily from weaning at 25 days until 105 days of age with either saline (n = 30, controls), 10 (n = 25, low dose) or 20 (n = 30, high dose) mg/kg body weight of BN 52021. The overall incidence of IDDM was unaffected by treatment. Quantitative analysis of insulin area showed a dose-dependent protection of β cells by Ginkgolide B, reflected in a 6- (low dose) to 8-fold (high dose) (P < 0. 01-0. 005) increase in the insulin/glucagon cell ratio compared to the saline treated rats. Ginkgolide B reduced severe insulitis from 84% in the saline rats developing IDDM to 59% (n. s.) in the low and to 33% (P < 0. 001) in the high dose group. These data suggest that PAF inhibitors may prove useful in immunomodulator therapy of IDDM since β cells are preserved.

Publishing year

1991-01-01

Language

English

Pages

225-235

Publication/Series

Autoimmunity

Volume

9

Issue

3

Document type

Journal article

Publisher

Taylor & Francis

Topic

  • Endocrinology and Diabetes

Keywords

  • Autoimmunity
  • Diabetes mellitus
  • Eosinophils
  • Glucagon
  • Insulin
  • Morphometry

Status

Published

ISBN/ISSN/Other

  • ISSN: 0891-6934