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Tissue transglutaminase autoantibodies in children with newly diagnosed type 1 diabetes are related to human leukocyte antigen but not to islet autoantibodies : A Swedish nationwide prospective population-based cohort study

Author:
  • Mara Cerqueiro Bybrant
  • Lena Grahnquist
  • Eva Örtqvist
  • Cecilia Andersson
  • Gun Forsander
  • Helena Elding Larsson
  • Åke Lernmark
  • Johnny Ludvigsson
  • Claude Marcus
  • Annelie Carlsson
  • Sten A. Ivarsson
Publishing year: 2018-11-16
Language: English
Pages: 221-227
Publication/Series: Autoimmunity
Volume: 51
Issue: 5
Document type: Journal article
Publisher: Taylor & Francis

Abstract english

Objectives: This study explored the association between tissue transglutaminase autoantibody (tTGA), high-risk human leucocyte antigen (HLA) genotypes and islet autoantibodies in children with newly diagnosed type 1 diabetes (T1D). Patients and methods: Dried blood spots and serum samples were taken at diagnosis from children <18 years of age participating in Better Diabetes Diagnosis (BDD), a Swedish nationwide prospective cohort study of children newly diagnosed with T1D. We analyzed tTGA, high-risk HLA DQ2 and DQ8 (DQX is neither DQ2 nor DQ8) and islet auto-antibodies (GADA, IA-2A, IAA, and three variants of Zinc transporter; ZnT8W, ZnT8R, and ZnT8QA). Results: Out of 2705 children diagnosed with T1D, 85 (3.1%) had positive tTGA and 63 (2.3%) had borderline values. The prevalence of tTGA was higher in children with the HLA genotypes DQ2/2, DQ2/X or DQ2/8 compared to those with DQ8/8 or DQ8/X (p =.00001) and those with DQX/X (p ≤.00001). No significant differences were found in relation to islet autoantibodies or age at diagnosis, but the presence of tTGA was more common in girls than in boys (p =.018). Conclusion: tTGA at T1D diagnosis (both positive and borderline values 5.4%) was higher in girls and in children homozygous for DQ2/2, followed by children heterozygous for DQ2. Only children with DQ2 and/or DQ8 had tTGA. HLA typing at the diagnosis of T1D can help to identify those without risk for CD.

Keywords

  • Endocrinology and Diabetes
  • Pediatrics
  • celiac disease
  • human leukocyte antigen
  • islet autoantibodies
  • tissue transglutaminase antibodies
  • Type 1 diabetes

Other

Published
  • Paediatric Endocrinology
  • Diabetes and Celiac Unit
  • PediatricCeliaki/Diabetes
  • ISSN: 0891-6934
E-mail: ake [dot] lernmark [at] med [dot] lu [dot] se

Principal investigator

Diabetes and Celiac Unit

+46 40 39 19 01

+46 70 616 47 79

60:11:015

Jan Waldenströms gata 35, Malmö

33

Lund University Diabetes Centre, CRC, SUS Malmö, Jan Waldenströms gata 35, House 91:12. SE-214 28 Malmö. Telephone: +46 40 39 10 00