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Åke Lernmark

Principal investigator

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Tissue transglutaminase autoantibodies in children with newly diagnosed type 1 diabetes are related to human leukocyte antigen but not to islet autoantibodies : A Swedish nationwide prospective population-based cohort study

Author

  • Mara Cerqueiro Bybrant
  • Lena Grahnquist
  • Eva Örtqvist
  • Cecilia Andersson
  • Gun Forsander
  • Helena Elding Larsson
  • Åke Lernmark
  • Johnny Ludvigsson
  • Claude Marcus
  • Annelie Carlsson
  • Sten A. Ivarsson

Summary, in English

OBJECTIVES: This study explored the association between tissue transglutaminase autoantibody (tTGA), high-risk human leucocyte antigen (HLA) genotypes and islet autoantibodies in children with newly diagnosed type 1 diabetes (T1D).

PATIENTS AND METHODS: Dried blood spots and serum samples were taken at diagnosis from children <18 years of age participating in Better Diabetes Diagnosis (BDD), a Swedish nationwide prospective cohort study of children newly diagnosed with T1D. We analyzed tTGA, high-risk HLA DQ2 and DQ8 (DQX is neither DQ2 nor DQ8) and islet auto-antibodies (GADA, IA-2A, IAA, and three variants of Zinc transporter; ZnT8W, ZnT8R, and ZnT8QA).

RESULTS: Out of 2705 children diagnosed with T1D, 85 (3.1%) had positive tTGA and 63 (2.3%) had borderline values. The prevalence of tTGA was higher in children with the HLA genotypes DQ2/2, DQ2/X or DQ2/8 compared to those with DQ8/8 or DQ8/X (p = .00001) and those with DQX/X (p ≤ .00001). No significant differences were found in relation to islet autoantibodies or age at diagnosis, but the presence of tTGA was more common in girls than in boys (p = .018).

CONCLUSION: tTGA at T1D diagnosis (both positive and borderline values 5.4%) was higher in girls and in children homozygous for DQ2/2, followed by children heterozygous for DQ2. Only children with DQ2 and/or DQ8 had tTGA. HLA typing at the diagnosis of T1D can help to identify those without risk for CD.

Department/s

  • Paediatric Endocrinology
  • EXODIAB: Excellence in Diabetes Research in Sweden
  • Diabetes and Celiac Unit
  • PediatricCeliaki/Diabetes

Publishing year

2018-11-16

Language

English

Pages

221-227

Publication/Series

Autoimmunity

Volume

51

Issue

5

Document type

Journal article

Publisher

Taylor & Francis

Topic

  • Endocrinology and Diabetes
  • Pediatrics

Keywords

  • celiac disease
  • human leukocyte antigen
  • islet autoantibodies
  • tissue transglutaminase antibodies
  • Type 1 diabetes

Status

Published

Research group

  • Paediatric Endocrinology
  • Diabetes and Celiac Unit
  • PediatricCeliaki/Diabetes

ISBN/ISSN/Other

  • ISSN: 0891-6934