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Åke Lernmark

Principal investigator

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IL-1β modulation of spontaneous autoimmune diabetes and thyroiditis in the BB rat

Author

  • C. A. Wilson
  • C. Jacobs
  • P. Baker
  • D. G. Baskin
  • S. Dower
  • A. Lernmark
  • B. Toivola
  • S. Vertrees
  • D. Wilson

Summary, in English

Long term effects of in vivo treatment with human rIL-1β on diabetogenesis and thyroid disease were determined in the Biobreeding rat. Administration of high dose (10 μg/kg) IL-1β accelerated the onset of insulin-dependent diabetes mellitus compared to saline-injected controls. High dose treatment resulted in goiter development, pronounced LT, reduced serum T4 levels, and overall growth reduction. In contrast, low dose IL-1β (0.5 μg/kg) administration significantly reduced the frequency of insulin-dependent diabetes mellitus (48%) compared to placebo (86%) and high dose IL-1β (93%) treatment groups. Rats protected by low dose IL-1β had unaffected growth rates and minimal to no pancreatic and thyroid pathology. Our results demonstrate that exogenous administration of IL-1β modulates Biobreeding rat idiopathic autoimmune diabetes and thyroid disease in a dose-dependent manner.

Department/s

  • Department of Translational Medicine

Publishing year

1990-06-08

Language

English

Pages

3784-3788

Publication/Series

Journal of Immunology

Volume

144

Issue

10

Document type

Journal article

Publisher

American Association of Immunologists

Status

Published

ISBN/ISSN/Other

  • ISSN: 0022-1767