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Cord blood islet autoantibodies are related to stress in the mother during pregnancy.

Author:
  • Barbro Lernmark
  • Kristian Lynch
  • Åke Lernmark
  • DiPiS Study Group
Publishing year: 2006
Language: English
Pages: 345-349
Publication/Series: Annals of the New York Academy of Sciences
Volume: 1079
Issue: 1079
Document type: Journal article
Publisher: New York Academy of Sciences

Abstract english

A 2-month psychological questionnaire concerning pregnancy was answered by 20,920 nondiabetic mothers of singletons. Retrospective analysis showed increased levels of islet autoantibodies (1A) in 290 (1.4%) newborns. High IA levels in the child's cord blood correlated strongly with IA levels in the mother (GADA r = 0.91, P < 0.0001; IA-2A r = 0.75, P = 0.0001). High IA levels were found in newborns whose mothers during pregnancy had been more worried than usual (P = 0.04), had worried that the child would be sick (P = 0.01) or not survive (P = 0.002), or had experienced serious life events, like "serious accident in the family" (P < 0.0001) or "experienced violence" (P = 0.02). Associations with increased worries by the mother remained in newborns with high type 1 diabetes mellitus (T1DM)-human leukocyte antigen (HLA) risk, but not in non-HLA risk children. ne prospective follow-up of these children will determine the importance of this early 1A for postnatal islet autoimmunity, type I diabetes, or both.

Keywords

  • Endocrinology and Diabetes
  • autoantibodies
  • stress
  • type 1 diabetes

Other

Published
  • Diabetes and Celiac Unit
  • ISSN: 0077-8923
E-mail: ake [dot] lernmark [at] med [dot] lu [dot] se

Principal investigator

Diabetes and Celiac Unit

+46 40 39 19 01

+46 70 616 47 79

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Jan Waldenströms gata 35, Malmö

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Lund University Diabetes Centre, CRC, SUS Malmö, Jan Waldenströms gata 35, House 91:12. SE-214 28 Malmö. Telephone: +46 40 39 10 00