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Åke Lernmark

Principal investigator

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Impaired glucagon response to sympathetic nerve stimulation in the BB diabetic rat: effect of early sympathetic islet neuropathy.

Author

  • Thomas O Mundinger
  • Qi Mei
  • Dianne P Figlewicz
  • Åke Lernmark
  • Gerald J Jr Taborsky

Summary, in English

We investigated the functional impact of a recently described islet-specific loss of sympathetic nerves that occurs soon after the autoimmune destruction of beta-cells in the BB diabetic rat (35). We found that the portal venous (PV) glucagon response to sympathetic nerve stimulation (SNS) was markedly impaired in newly diabetic BB rats (BB D). We next found a normal glucagon response to intravenous epinephrine in BB D, eliminating the possibility of a generalized secretory defect of the BB D alpha-cell as the mediator of the impaired glucagon response to SNS. We then sought to determine whether the glucagon impairment to SNS in BB D was due solely to their loss of islet sympathetic nerve terminals or whether other effects of autoimmune diabetes contributed. We therefore reproduced, in nondiabetic Wistar rats, an islet nerve terminal loss similar to that in BB D with systemic administration of the sympathetic neurotoxin 6-hydroxydopamine. The impairment of the glucagon response to SNS

Publishing year

2003

Language

English

Pages

1047-1054

Publication/Series

American Journal of Physiology: Endocrinology and Metabolism

Volume

285

Issue

5

Document type

Journal article

Publisher

American Physiological Society

Topic

  • Physiology

Status

Published

ISBN/ISSN/Other

  • ISSN: 1522-1555