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Åke Lernmark

Principal investigator

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Diabetes segregates as a single locus in crosses between inbred BB rats prone or resistant to diabetes

Author

  • Helle Markholst
  • Susan Eastman
  • Deborah Wilson
  • Bodil E. Andreasen
  • Åke Lernmark

Summary, in English

Diabetes-prone (DP) BB rats spontaneously develop insulin-dependent diabetes resembling type 1 diabetes mellitus in man. They also exhibit lifelong T cell deficiency. The segregation of both diabetes and lymphopenia was studied in crosses between this inbred line of rats and the related but nondiabetic and nonlymphopenic inbred diabetes-resistant (DR) BB rat line. Diabetes segregated as a single, autosomal recessive trait and was always accompanied by lymphopenia. Among the limited number ofdifferences in the genomic DNA sequences of the two lines, DP and DR BB, one may account for the development of diabetes and lymphopenia in the DP BB rats. It may be possible to screen the genomic DNA for such differences to detect a marker for thephenotypes.

Publishing year

1991-07-01

Language

English

Pages

297-300

Publication/Series

Journal of Experimental Medicine

Volume

174

Issue

1

Document type

Journal article

Publisher

Rockefeller University Press

Topic

  • Endocrinology and Diabetes

Status

Published

ISBN/ISSN/Other

  • ISSN: 0022-1007