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Åke Lernmark

Principal investigator

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Effects of dextran-linked chloromercuribenzoic acid on insulin release from microdissected pancreatic islets

Author

  • Stig Åkerstrom
  • Bo Hellman
  • Åker Lernmark
  • Bernt Lindberg
  • Monica Söderberg
  • Inge Bert Täljedal

Summary, in English

Insulin release in response to dextran-linked p-chloromercuribenzoic acid was studied in microdissected pancreatic islets of non-inbred ob/ob-mice. No contamination of the dextran-linked mercurial with free chloromercuribenzoic acid was detected before or after the incubation with islets. In comparison with free mercurial, of the same thiol-blocking activity, the dextran-linked compound had a weak insulin-releasing action with a different dose vs. response relationship. The dextran-linked mercurial had no demonstrable effect on the islet content of cyclic AMP. The results support the hypothesis that free organic mercurials mainly stimulate insulin release by blocking thiol groups that are embedded within the β-cell plasma membranes beneath their surfaces.

Publishing year

1976-11-18

Language

English

Pages

96-105

Publication/Series

BBA - General Subjects

Volume

451

Issue

1

Document type

Journal article

Publisher

Elsevier

Topic

  • Endocrinology and Diabetes

Status

Published

ISBN/ISSN/Other

  • ISSN: 0304-4165