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Åke Lernmark

Principal investigator

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Seroconversion to Islet Autoantibodies After Enterovirus Infection in Early Pregnancy.

Author

  • Sabina Rešić Lindehammer
  • Hanna Honkanen
  • William Allan Nix
  • Maarit Oikarinen
  • Kristian Lynch
  • Ida Jönsson
  • Karel Marsal
  • Steven Oberste
  • Heikki Hyöty
  • Åke Lernmark

Summary, in English

Gestational enterovirus (EV) infections have been associated with an increased risk for type 1 diabetes in the offspring. We therefore analyzed non-diabetic mothers for EV exposure in early pregnancy in relation to type 1 diabetes HLA-DQ risk genotypes and seroconversion to islet autoantibodies during pregnancy. Non-diabetic mothers who had islet autoantibodies (n=365) against glutamic acid decarboxylase (GADA), islet antigen-2 autoantibodies (IA-2A), or insulin autoantibodies (IAA), in early pregnancy and at delivery were compared to islet autoantibody-negative mothers (n=1457) matched for age and sampling date. Mothers were genotyped for HLA-DQ and analyzed for both EV-RNA and EV-IgM. EV-IgM, but not EV-RNA, was detected during early pregnancy in 12% of islet autoantibody-positive mothers compared to 11% of the controls. In early pregnancy, mothers with HLA-DQ 2/2 or 2/X genotypes showed an increased risk for islet autoantibodies at delivery (OR 1.85; p=0.001). After adjusting for parity, maternal age, year of birth, and season of early pregnancy, early pregnancy EV-IgM combined with DQ2/2 or 2/X increased the risk for islet autoantibodies (OR 3.10; 95% CI 1; p=0.008). EV-IgM in early pregnancy increased the risk for islet autoantibodies at delivery in non-diabetic mothers with HLA-DQ 2/2 or 2/X type 1 diabetes risk genotypes.

Department/s

  • Diabetes and Celiac Unit
  • Paediatric Endocrinology
  • Obstetrics and Gynaecology (Lund)
  • EXODIAB: Excellence in Diabetes Research in Sweden
  • EpiHealth: Epidemiology for Health

Publishing year

2012

Language

English

Pages

254-261

Publication/Series

Viral Immunology

Volume

25

Issue

4

Document type

Journal article

Publisher

Mary Ann Liebert, Inc.

Topic

  • Immunology in the medical area

Status

Published

Research group

  • Diabetes and Celiac Unit
  • Paediatric Endocrinology

ISBN/ISSN/Other

  • ISSN: 0882-8245