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Åke Lernmark

Principal investigator

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Type 1 diabetes-related autoantibodies are rare in Alaska native populations.

Author

  • J Mohatt
  • LK Gilliam
  • L Bekris
  • S Ebbesson
  • Åke Lernmark

Summary, in English

OBJECTIVES: When clinical data were initially gathered from the Alaskan Eskimos in the 1950's, diabetes mellitus was noted to be quite rare. The prevalence of diabetes has increased significantly since that time, with rates of 10% reported recently in some Alaska native populations. Our goal was to understand the pathogenesis of diabetes among these groups, with the hypothesis that Alaskan Eskimos were predominantly affected by type 2 diabetes, not by latent autoimmune diabetes in adults (LADA). STUDY DESIGN: Population based case control study METHODS: We tested sera from subjects in two Eskimo villages for the presence of type 1 diabetes-related autoantibodies against glutamic acid decarboxylase (GAD65Ab) and tyrosine phosphatase-like islet antigen-2 (IA-2Ab). RESULTS: Among subjects from one Inupiat village (#1) and one SiberianYup'ik village (#2), there were 21 subjects with diabetes mellitus (DM), 17 with impaired glucose tolerance (IGT), and 226 healthy controls with normal gluco

Publishing year

2002

Language

English

Pages

21-21

Publication/Series

Circumpolar Health Supplements

Volume

61

Issue

Feb

Document type

Journal article

Publisher

International Association of Circumpolar Health Publishers

Topic

  • Endocrinology and Diabetes

Status

Published

ISBN/ISSN/Other

  • ISSN: 1797-2361