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Prenatal viral exposure followed by adult stress produces glucose intolerance in a mouse model.

Author:
  • B Niklasson
  • A Samsioe
  • M Blixt
  • S Sandler
  • A Sjöholm
  • E Lagerquist
  • Åke Lernmark
  • W Klitz
Publishing year: 2006
Language: English
Pages: 2192-2199
Publication/Series: Diabetologia
Volume: 49
Issue: 9
Document type: Journal article
Publisher: Springer

Abstract english

AIMS/HYPOTHESIS: It has been suggested that the uterine environment may influence metabolic disease occurring later in adult life, and that adult stress may promote disease outcome. Using a mouse model, we tested whether in utero exposure to Ljungan virus (LV) followed by adult exposure to stress produces diabetes. The influence of the timing of viral exposure over the course of pregnancy was also tested. MATERIALS AND METHODS: Pregnant CD-1 mice were exposed i.p. to LV on pregnancy days 4, 8, 12 or 17. Adult male mice from these pregnancies were stressed by being kept in shared cages. Stress only, LV exposure in utero only, and no-stress/no virus exposure groups were also followed. Outcome variables included bodyweight, epididymal fat weight, baseline glucose, glucose tolerance tests (60 and 120 min) and serum insulin. RESULTS: We demonstrated that male mice developed a type 2-like diabetes, including obesity, as adults if infected during pregnancy with LV. Diabetes at the age of 11 w

Keywords

  • Endocrinology and Diabetes
  • Diabetes
  • Fetal programming
  • Ljungan virus
  • Mouse model
  • Stress
  • Type 2 diabetes

Other

Published
  • ISSN: 1432-0428
E-mail: ake [dot] lernmark [at] med [dot] lu [dot] se

Principal investigator

Diabetes and Celiac Unit

+46 40 39 19 01

+46 70 616 47 79

60:11:015

Jan Waldenströms gata 35, Malmö

33

Lund University Diabetes Centre, CRC, SUS Malmö, Jan Waldenströms gata 35, House 91:12. SE-214 28 Malmö. Telephone: +46 40 39 10 00