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Åke Lernmark

Principal investigator

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Genetic dissection of autoimmune type I diabetes in the BB rat

Author

  • Howard J. Jacob
  • Anna Pettersson
  • Deborah Wilson
  • Yipei Mao
  • Åke Lernmark
  • Eric S. Lander

Summary, in English

The BB rat is among the best models of insulin−dependent diabetes mellitus — with onset and pathogenesis closely resembling the human disease. One unusual feature is a severe T−cell lymphopenia, which appears to be inherited as a recessive trait controlled by a single gene, Lyp. Based on genetic analysis of several crosses, we show that development of diabetes involves at least three genes: Lyp, which is tightly linked to the neuropeptide Y (Npy) gene on chromosome 4, a gene linked to the major histocompatibility complex (MHC) on chromosome 20, and a third unmapped gene for which the Fischer rat strain carries an allele conferring resistance.

Publishing year

1992-01-01

Language

English

Pages

56-60

Publication/Series

Nature Genetics

Volume

2

Issue

1

Document type

Journal article

Publisher

Nature Publishing Group

Status

Published

ISBN/ISSN/Other

  • ISSN: 1061-4036