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Åke Lernmark

Principal investigator

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Islet cell antibody reactivity with human fetal pancreatic islets

Author

  • Göran Sundkvist
  • Agneta Bergqvist
  • Henrik Weibull
  • David Bergqvist
  • Kaj Fält
  • Mona Landin Olsson
  • Åke Lernmark

Summary, in English

To evaluate the possibility of autoimmune processes against pancreatic islets in fetal life, we tested islet cell antibody (ICA) reactivity with 14 fetal pancreata obtained after abortion at the 15th up to the 19th week of gestation. Pancreatic islets positive for a monoclonal proinsulin antibody but non-reactive with ICA negative control serum were found in 9 14 pancreata and all ( 9 9) of them showed a positive reaction with the ICA standard. It is concluded that ICA reactivity may be detected in fetal human pancreata. Further studies on fetal islet cell antibody reactivity in the development of insulin dependent diabetes mellitus (IDDM) are warranted.

Department/s

  • Department of Translational Medicine

Publishing year

1991-01-01

Language

English

Pages

1-7

Publication/Series

Diabetes Research and Clinical Practice

Volume

14

Issue

1

Document type

Journal article

Publisher

Elsevier

Topic

  • Endocrinology and Diabetes

Keywords

  • Autoimmunity
  • Fetal islets
  • Islet cell antibodies
  • Islet cell antigens

Status

Published

ISBN/ISSN/Other

  • ISSN: 0168-8227