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Newly diagnosed latent autoimmune diabetes in adults (LADA) is associated with low level glutamate decarboxylase (GAD65) and IA-2 autoantibodies

Author:
  • D. B. Schranz
  • L Bekris
  • M. Landin-Olsson
  • C. Törn
  • A. Niläng
  • Å Toll
  • J. Sjöström
  • H. Grönland
  • Åke Lernmark
Publishing year: 2000
Language: English
Pages: 133-138
Publication/Series: Hormone and Metabolic Research
Volume: 32
Issue: 4
Document type: Journal article
Publisher: Georg Thieme Verlag

Abstract english

A quantitative assay with microSepharose was used to determine GAD65Ab and IA-2Ab levels in 771 population-based patients diagnosed with diabetes mellitus at 15 to 34 years of age, and in 828 matched controls. Among the patients, 587 (76%) were classified with type I, 108 (14%) with type II, and 76 (10%) with unclassifiable diabetes. The levels above normal demonstrated a prevalence of GAD65Ab in 66% of type I diabetes, 50% of type II diabetes and 54% of unclassifiable patients and for IA-2Ab in 40%, 17% and 21%, respectively. Among the autoantibody-positive sera, the LADA patients had a lower GAD65Ab index (median 0.19, p < 0.0001) and IA-2Ab index (median 0.28, p < 0.0001) than the type I patients (median 0.37 and 0.66). Patients with unclassifiable diabetes had a GAD65Ab (median 0.43) or IA-2Ab (median 0.63) index which was not different from the type I diabetes patients. Our data demonstrate that young adult new-onset LADA patients have low level GAD65Ab and IA-2Ab. The low-level autoantibodies may signify a less aggressive beta- cell autoimmunity, which may explain why these patients are often classified with type II or non-insulin-dependent diabetes.

Keywords

  • Autoimmunity
  • Diabetes Mellitus
  • Islet Cell Autoantibodies
  • ROC Curve
  • Type I Diabetes
  • Type II Diabetes

Other

Published
  • ISSN: 0018-5043
E-mail: ake [dot] lernmark [at] med [dot] lu [dot] se

Principal investigator

Diabetes and Celiac Unit

+46 40 39 19 01

+46 70 616 47 79

60:11:015

Jan Waldenströms gata 35, Malmö

33

Lund University Diabetes Centre, CRC, SUS Malmö, Jan Waldenströms gata 35, House 91:12. SE-214 28 Malmö. Telephone: +46 40 39 10 00