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Åke Lernmark

Principal investigator

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Insulin release by glucagon and secretin : studies with secretin-glucagon hybrids

Author

  • H. Kofod
  • D. Andreu
  • P. Thams
  • R. B. Merrifield
  • C. J. Hedeskov
  • B. Hansen
  • A. Lernmark

Summary, in English

Secretin and glucagon potentiate glucose-induced insulin release. We have compared the effects of secretin and glucagon with that of four hybrid molecules of the two hormones on insulin release and formation of cyclic AMP (cAMP) in isolated mouse pancreatic islets. All six peptides potentiated the release of insulin at 10mM D-glucose, and their effects were indistinguishable with respect to the dynamics of release, dose-response relationship, and glucose dependency. However, measurements of cAMP accumulation in the presence of the phosphodiesterase inhibitor 3-isobutyl-1-methylxanthine (10-4M) showed that the fold increase compared with glucose alone had the following ranking order: secretin = [Tyr10, Tyr13]-secretin 1.6<[Tyr10, Tyr13, Trp25]secretin 1.8<glucagon 1.9<[Asp3, Glu9, Arg12]glucagon 2.3 = [Asp3, Glu9]glucagon. These results suggest that despite similar potentiating effects of secretin and glucagon on glucose-induced insulin release, their modes of action may be different.

Publishing year

1988-01-01

Language

English

Publication/Series

American Journal of Physiology - Endocrinology and Metabolism

Volume

254

Issue

4

Document type

Journal article

Publisher

American Physiological Society

Status

Published

ISBN/ISSN/Other

  • ISSN: 0193-1849