Your browser has javascript turned off or blocked. This will lead to some parts of our website to not work properly or at all. Turn on javascript for best performance.

The browser you are using is not supported by this website. All versions of Internet Explorer are no longer supported, either by us or Microsoft (read more here: https://www.microsoft.com/en-us/microsoft-365/windows/end-of-ie-support).

Please use a modern browser to fully experience our website, such as the newest versions of Edge, Chrome, Firefox or Safari etc.

Default user image.

Åke Lernmark

Principal investigator

Default user image.

Islet transplantation in mice differing in the I and S subregions of the H-2 complex

Author

  • Michael W. Steffes
  • Otto Nielsen
  • Thomas Dyrberg
  • Steinunn Baekkeskov
  • Joanne Scott
  • Åke Lernmark

Summary, in English

Diabetic A.TL and A.TH mice, congenic inbred strains differing only in the I and S (non-K, non-D) regions of the major histocompatibility (H-2) complex, received intrasplenic allogeneic and isogeneic pancreatic islet transplants. The isografts were uniformly accepted, while approximately 60% of the recipients receiving allografts rejected the islets, most within 4 weeks of transplantation. With either strain the animals accepting the allografts had higher blood glucose values than normal mice or isografted recipients. After a minimum of 13 weeks of nearly normal glucose levels, successfully alografted mice received skin grafts and spleen cells. None of the A.TH recipients rejected the A.TL islets, but two of four A.TL recipients of A.TH islets became diabetic after the skin grafts. These observations suggest a variable response to islets transplanted across this isolated difference of the H-2 complex. Furthermore, allografted islets resisting rejection did not provide normal glucose levels in the recipients.

Publishing year

1981-01-01

Language

English

Pages

476-479

Publication/Series

Transplantation

Volume

31

Issue

6

Document type

Journal article

Publisher

Lippincott Williams & Wilkins

Status

Published

ISBN/ISSN/Other

  • ISSN: 0041-1337