Your browser has javascript turned off or blocked. This will lead to some parts of our website to not work properly or at all. Turn on javascript for best performance.

The browser you are using is not supported by this website. All versions of Internet Explorer are no longer supported, either by us or Microsoft (read more here: https://www.microsoft.com/en-us/microsoft-365/windows/end-of-ie-support).

Please use a modern browser to fully experience our website, such as the newest versions of Edge, Chrome, Firefox or Safari etc.

Default user image.

Åke Lernmark

Principal investigator

Default user image.

Secretion uncouples glucose inhibition of glucagon-producing cells resulting in a simultaneous stimulation of both glucagon and insulin release

Author

  • Hans Kofod
  • Jens J. Holst
  • Åke Lernmark

Summary, in English

The effect of secretin on glucagon and insulin release and its interaction with glucose has been studied in cultured mouse pancreatic islets by column perifusion. Glucose alone showed the well-known stimulation of insulin release and inhibition of glucagon release. Addition of 10 mM secretin increased glucagon secretion at 3 mM d-glucose by 300% while no change in insulin release could be seen at this low glucose concentration. At maximal stimulation of insulin release by 20 mM d-glucose addition of 10 nM secretin increased insulin release by 30%. Despite this insulin concentration and the high glucose concentration an increase in glucagon secretion of 1800% was found. These effects of secretin were dose-dependent at 10 mM d-glucose with 1 nM secretin being the lowest effective dose.

Publishing year

1988-01-01

Language

English

Pages

315-322

Publication/Series

Regulatory Peptides

Volume

23

Issue

3

Document type

Journal article

Publisher

Elsevier

Keywords

  • Mouse
  • Pancreatic hormone
  • Pancreatic islet

Status

Published

ISBN/ISSN/Other

  • ISSN: 0167-0115