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Åke Lernmark

Principal investigator

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Maternal enterovirus infection during pregnancy as a risk factor in offspring diagnosed with type 1 diabetes between 15 and 30 years of age.

Author

  • Maria Elfving
  • Johan Svensson
  • Sami Oikarinen
  • Björn Jonsson
  • Per Olofsson
  • Göran Sundkvist
  • Bengt Lindberg
  • Åke Lernmark
  • Heikki Hyöty
  • Sten Ivarsson

Summary, in English

Maternal enterovirus infections during pregnancy may increase the risk of offspring developing type 1 diabetes during childhood. The aim of this study was to investigate whether gestational enterovirus infections increase the offspring's risk of type 1 diabetes later in life. Serum samples from 30 mothers without diabetes whose offspring developed type 1 diabetes between 15 and 25 years of age were analyzed for enterovirus-specific immunoglobulin M (IgM) antibodies and enterovirus genome (RNA), and compared to a control group. Among the index mothers, 9/30 (30%) were enterovirus IgM-positive, and none was positive for enterovirus RNA. In the control group, 14/90 (16%) were enterovirus IgM-positive, and 4/90 (4%) were positive for enterovirus RNA (n.s.). Boys of enterovirus IgM-positive mothers had approximately 5 times greater risk of developing diabetes (OR 4.63; 95% CI 1.22-17.6), as compared to boys of IgM-negative mothers (P < .025). These results suggest that gestational enterovirus infections may be related to the risk of offspring developing type 1 diabetes in adolescence and young adulthood.

Department/s

  • Paediatrics (Lund)
  • Paediatric Endocrinology
  • Department of Clinical Sciences, Malmö

Publishing year

2008

Language

English

Publication/Series

Experimental Diabetes Research

Volume

2008

Document type

Journal article

Publisher

Hindawi Limited

Topic

  • Endocrinology and Diabetes

Status

Published

Research group

  • Paediatric Endocrinology

ISBN/ISSN/Other

  • ISSN: 1687-5214