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Åke Lernmark

Principal investigator

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Immunoreactive trypsin(Ogen) in the sera of children with recent-onset insulin-dependent diabetes and matched controls

Author

  • Mona Landin-Olsson
  • Anders Borgstrom
  • Leif Blom
  • Goran Sundkvist
  • Ake Lernmark
  • L. Nyström
  • A. Sandström
  • S. Wall
  • M. Aili
  • H. Bäckman
  • E. Carlsson
  • H. Edenwall
  • P. O. Elfstrand
  • B. W. Granström
  • I. Gustavsson
  • L. E. Gustavsson
  • A. Hallberg
  • B. Hansing
  • R. Hanås
  • L. Hellenberg
  • E. Holmberg
  • H. Hornell
  • G. Jonsell
  • C. Jönsson
  • K. Kockum
  • U. Lindberg
  • B. Lindblad
  • J. Ludvigsson
  • V. Mazreliez
  • U. Myrdal
  • J. Neiderud
  • K. O. Nilsson
  • B. Persson
  • P. G. Petzén
  • G. Samuelsson
  • K. Segnestam
  • N. Sigurs
  • S. Sjöblad
  • S. Sjögren
  • L. Skogsberg
  • T. Smith
  • K. Snellman
  • L. Strömberg
  • U. Ståle
  • J. Tenstam
  • B. Thalme
  • A. Thilén
  • K. Tullus
  • T. Tuvemo
  • O. Westphal

Summary, in English

To evaluate the exocrine pancreatic function at the time of diagnosis of insulin-dependent diabetes mellitus, we determined immunoreactive an-odal and cathodal trypsin(ogen) levels in sera from almost all children (n = 375) 0-14 years of age in Sweden in whom diabetes developed during 1 year, and in sex-, age-, and geographically matched control subjects (n = 312). The median level of anodal trypsin(ogen) was 5 (quartile range, 3-7) µg/L in children with newly diagnosed diabetes, compared with a median level of 7 (quartile range, 4-8) µg/L in control subjects (p < 0.0001). Similarly, the median level of cathodal trypsin(ogen) was 8 (quartile range, 4-10) µg/L in children with diabetes, compared with a median level of 11 (quartile range, 7-15) µg/L in control subjects (p < 0.0001). The median of the individual ratios between cathodal and anodal trypsin(ogen) was 1.4 in the diabetic patients and 1.7 in the control children (p < 0.001). In a multivariate test, however, only the decrease in cathodal trypsin(ogen) concentration was associated with diabetes. The levels of trypsin(ogen)s did not correlate with levels of islet cell antibodies, present in 81% of the diabetic children. Several mechanisms may explain our findings, for example, similar pathogenetic factors may affect both the endocrine and exocrine pancreas simultaneously, a failing local trophic stimulation by insulin on the exocrine cells may decrease the trypsinogen production, and there may be an increased elimination of trypsin(ogen) because of higher filtration through the kidneys in the hyperglycemic state.

Department/s

  • Autoimmunity and kidney diseases
  • Respiratory Medicine and Allergology
  • Vascular Diseases - Clinical Research
  • Clinical Sciences, Helsingborg
  • Paediatric Endocrinology
  • Division of Occupational and Environmental Medicine, Lund University
  • Occupational Therapy and Occupational Science
  • Department of Health Sciences
  • Care in high technological environments
  • Paediatrics (Lund)

Publishing year

1990-01-01

Language

English

Pages

241-247

Publication/Series

Pancreas

Volume

5

Issue

3

Document type

Journal article

Publisher

Lippincott Williams & Wilkins

Keywords

  • Anodal trypsin-(ogen)
  • Case-control study
  • Cathodal trypsin(ogen)
  • Exocrine pancreatic function
  • Insulin-dependent diabetic children

Status

Published

Research group

  • Autoimmunity and kidney diseases
  • Vascular Diseases - Clinical Research
  • Paediatric Endocrinology
  • Occupational Therapy and Occupational Science
  • Care in high technological environments

ISBN/ISSN/Other

  • ISSN: 0885-3177