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Åke Lernmark

Principal investigator

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Psychological manifestations of celiac disease autoimmunity in young children

Author

  • Laura B. Smith
  • Kristian Lynch
  • Kalle Kurppa
  • Sibylle Koletzko
  • Jeffrey Krischer
  • Edwin Liu
  • Suzanne Bennett Johnson
  • Daniel Agardh
  • Marian Rewers
  • Kimberly Bautista
  • Judith Baxter
  • Åke Lernmark
  • Carin Andrén Aronsson
  • Maria Ask
  • Jenny Bremer
  • Ulla Marie Carlsson
  • Corrado Cilio
  • Emelie Ericson-Hallström
  • Lina Fransson
  • Thomas Gard
  • Joanna Gerardsson
  • Rasmus Bennet
  • Monica Hansen
  • Gertie Hansson
  • Cecilia Harmby
  • Suzanne Hyberg-Karlsson
  • Fredrik Johansen
  • Berglind Jonsdottir
  • Helena Elding Larsson
  • Sigrid Lenrick Forss
  • Markus Lundgren
  • Maria Månsson-Martinez
  • Maria Markan
  • Marie Jessica Melin
  • Zeliha Mestan
  • Kobra Rahmati
  • Anita Ramelius
  • Anna Rosenquist
  • Falastin Salami
  • Sara Sibthorpe
  • Birgitta Sjöberg
  • Ulrica Swartling
  • Evelyn Tekum Amboh
  • Carina Törn
  • Anne Wallin
  • Åsa Wimar
  • Sofie Åberg
  • Kristian Lynch
  • Hemang Parikh
  • Kendra Vehik

Summary, in English

BACKGROUND AND OBJECTIVES: Psychological symptoms can be associated with celiac disease; abstract however, this association has not been studied prospectively in a pediatric cohort. We examined mother report of psychological functioning in children persistently positive for tissue transglutaminase autoantibodies (tTGA), defined as celiac disease autoimmunity (CDA), compared with children without CDA in a screening population of genetically at-risk children. We also investigated differences in psychological symptoms based on mothers' awareness of their child's CDA status. METHODS: The Environmental Determinants of Diabetes in the Young study followed 8676 children to identify triggers of type 1 diabetes and celiac disease. Children were tested for tTGA beginning at 2 years of age. The Achenbach Child Behavior Checklist assessed child psychological functioning at 3.5 and 4.5 years of age. RESULTS: At 3.5 years, 66 mothers unaware their child had CDA reported more child anxiety and depression, aggressive behavior, and sleep problems than 3651 mothers of children without CDA (all Ps ≤ .03). Unaware-CDA mothers also reported more child anxiety and depression, withdrawn behavior, aggressive behavior, and sleep problems than 440 mothers aware of their child's CDA status (all Ps ≤.04). At 4.5 years, there were no differences. CONCLUSIONS: In 3.5-year-old children, CDA is associated with increased reports of child depression and anxiety, aggressive behavior, and sleep problems when mothers are unaware of their child's CDA status. Mothers' knowledge of their child's CDA status is associated with fewer reports of psychological symptoms, suggesting that awareness of the child's tTGA test results affects reporting of symptoms.

Department/s

  • Diabetes and Celiac Unit
  • Diabetes - Immunovirology
  • Paediatric Endocrinology
  • Neonatology
  • EXODIAB: Excellence in Diabetes Research in Sweden

Publishing year

2017-03-01

Language

English

Publication/Series

Pediatrics

Volume

139

Issue

3

Document type

Journal article

Publisher

American Academy of Pediatrics

Topic

  • Pediatrics

Keywords

  • celiac disease
  • yong children
  • psychological

Status

Published

Research group

  • Diabetes and Celiac Unit
  • Diabetes - Immunovirology
  • Paediatric Endocrinology
  • Neonatology

ISBN/ISSN/Other

  • ISSN: 0031-4005