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Temporal Variation of Ljungan Virus Antibody Levels in Relation to Islet Autoantibodies and Possible Correlation to Childhood Type 1 Diabetes

  • Anna-Lena Nilsson
  • Eliza Lagerquist
  • Kristian Lynch
  • Åke Lernmark
  • Rolandsson Olov
Publishing year: 2009
Language: English
Pages: 61-66
Publication/Series: Open Pediatric Medicine Journal
Volume: 3
Document type: Journal article

Abstract english

Viral infection may trigger islet autoimmunity, type 1diabetes (T1D), or both. Fluctuating population density of

bank voles as a putative reservoir of Ljungan virus has been claimed to be associated with variations in T1D incidence

rate (IR). We tested the hypothesis that Ljungan virus antibodies reflecting prior exposure(s) to the virus may be

associated with islet autoimmunity, childhood diabetes or both. Incident, 0-18y, T1D patients (n = 63) were studied along

with age and sample time matched controls (n = 126). The younger children (< 9 years) tended to have a higher incidence

rate during winter (IR = 67.6, 95%CI 41.9-103.5) compared to summer (IR = 33.6, 95%CI 15.3-63.9) months. The

proportion of children with high level antibodies against Ljungan virus (LVAb) were both younger compared to the rest of

the children (p < 0.002) and correlated with half yearly T1D IR (r = 0.78, p = 0.005). High level LVAb fluctuating with

season and correlating with T1D IR indicates that past exposure to Ljungan virus may be associated with T1D.


  • Endocrinology and Diabetes
  • antibodies
  • Islet autoantibodies
  • Type 1 diabetes
  • Ljungan virus


  • LUDC (Lund University Diabetes Centre)-lup-obsolete
  • ISSN: 1874-3099
E-mail: ake [dot] lernmark [at] med [dot] lu [dot] se

Principal investigator

Diabetes and Celiac Unit

+46 40 39 19 01

+46 70 616 47 79


Jan Waldenströms gata 35, Malmö


Lund University Diabetes Centre, CRC, SUS Malmö, Jan Waldenströms gata 35, House 91:12. SE-214 28 Malmö. Telephone: +46 40 39 10 00