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Åke Lernmark

Principal investigator

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Isolation of rat major histocompatibility genes expressed in pancreatic β-cells

Author

  • W. H. Kastern
  • A. Lernmark
  • L. Lyngsie

Summary, in English

The probable role of cell surface antigens in the development of juvenile diabetes necessitates a detailed study of the proteins expressed on the surface of pancreatic β-cells. A gene library composed of genes expressed in β-cells was constructed to provide a source of low abundance genes from those cells. Initial studies with this library have led to the isolation of three genes which share nucleotide and amino acid sequence homology with mouse and human class I major histocompatibility antigens.

Publishing year

1983-01-01

Language

English

Pages

1135-1138

Publication/Series

Acta Biologica et Medica Germanica

Volume

41

Issue

12

Document type

Journal article

Publisher

Akademie Verlag GMBH

Status

Published

ISBN/ISSN/Other

  • ISSN: 0001-5318