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Åke Lernmark

Principal investigator

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Viruses, diabetes, and autoimmunity : Studies of subjects at genetic risk for type 1 diabetes

Author

  • Sabina Resic Lindehammer
  • Åke Lernmark

Editor

  • K. Taylor
  • H. Hyöty
  • A. Toniolo
  • A. J. Zuckerman

Summary, in English

The possible importance of virus infections before the development of islet autoimmunity and then for the appearance of clinical type 1 diabetes is reviewed. There is a lack of specific data on the role of virus to induce islet autoimmunity. There is also a paucity of data to demonstrate that virus infections may contribute to an accelerated disease process resulting in clinical onset of type 1 diabetes. In contrast, there is a plethora of studies on virus infections at the time of clinical onset. However, these studies have made the understanding of virus in type 1 diabetes less easy. Future studies need to address further gestational infections and the risk of the offspring for islet autoimmunity. Such studies should also investigate the mechanisms by which gestational infections may alter the ability of the offspring to respond to future virus infections related to the development of islet autoimmunity or accelerator of the clinical onset of diabetes.

Department/s

  • Medicine, Lund
  • Diabetes and Celiac Unit
  • EXODIAB: Excellence in Diabetes Research in Sweden

Publishing year

2013

Language

English

Pages

187-194

Publication/Series

Diabetes and Viruses

Volume

9781461440512

Document type

Book chapter

Publisher

Springer

Topic

  • Endocrinology and Diabetes

Status

Published

Research group

  • Diabetes and Celiac Unit

ISBN/ISSN/Other

  • ISBN: 9781461440505
  • ISBN: 9781461440512