Your browser has javascript turned off or blocked. This will lead to some parts of our website to not work properly or at all. Turn on javascript for best performance.

The browser you are using is not supported by this website. All versions of Internet Explorer are no longer supported, either by us or Microsoft (read more here:

Please use a modern browser to fully experience our website, such as the newest versions of Edge, Chrome, Firefox or Safari etc.

Default user image.

Åke Lernmark

Principal investigator

Default user image.

The genetic background of gestational diabetes mellitus


  • Anastasia Papadopoulou

Summary, in English

The aims of this work is to better determine the genetic background of gestational diabetes (GDM) and to examine how specific genes affect the development of diabetes post partum.

In the DiPiS (Diabetes Prediction in Skåne) study we typed for HLA-DQB1 alleled, the transcription factor 7-like 2(TCF7L2) rs7903146, rs12255372 and rs7901695 SNPs, the 1858 C>T SNP of the protein tyrosine phosphatase non-receptor 22 (PTPN22) gene and we tested for the presence of islet cell autoantibodies against glutamic acid decarboxylase 65 (GAD65), insulinoma-associated antigen 2 (IA-2) and insulin in women who had been diagnosed with GDM at least once during 2000-2004.

The HLA-DQB1*0602 allele which is considered to be protective for type 1 diabetes had a negative association with GDM even when excluding the autoantibody positive GDM women. There was a positive association between the type 2 diabetes associated TCF7L2 and GDM, regardless of the presence of islet cell autoantibodies or of HLA-DQB1*0602. The 1858 C>T SNP of the PTPN22 gene, which is considered a risk SNP for type 1 diabetes as well as other autoimmune disorders, had no association with GDM.

The HLA-DQB1*0602 had even a negative association with diabetes post partum in a group of GDM women diagnosed during 2003-2005 in the Mamma study in which we had follow-up data one to two years after delivery.

We conclude that GDM is a heterogeneous disorder which shares clinical features and genetic predisposition with both type 1 and type 2 diabetes. This is strengthened by the fact that GDM women have an increased risk to develop type 2 or even type 1 diabetes years after delivery.


  • EXODIAB: Excellence in Diabetes Research in Sweden
  • Diabetes and Celiac Unit

Publishing year





Lund University Faculty of Medicine Doctoral Dissertation Series



Document type



Dept of Diabetes and Celiac Disease


  • Endocrinology and Diabetes


  • Gestational diabetes mellitus
  • HLA
  • TCF7L2
  • PTPN22
  • Post partum diabetes
  • Type 1 Diabetes
  • Type 2 Diabetes
  • Islet Cell Autoantibodies



Research group

  • Diabetes and Celiac Unit


  • Åke Lernmark
  • Carl-David Agardh


  • ISSN: 1652-8220
  • ISBN: 978-91-86671-85-3

Defence date

6 May 2011

Defence time


Defence place

Medicin aula, ing.35, SUS, Malmö


  • Christian Berne (Prof.)