Javascript is not activated in your browser. This website needs javascript activated to work properly.
You are here

Increased galanin expression in the celiac ganglion of BB diabetic rats

  • Qi Mei
  • Thomas O Mundinger
  • Åke Lernmark
  • Gerald J Taborsky
Publishing year: 2006-02
Language: English
Pages: 1-10
Publication/Series: Neuropeptides
Volume: 40
Issue: 1
Document type: Journal article
Publisher: Elsevier

Abstract english

BB rats lose >50% of their islet sympathetic nerve terminals soon after diabetes onset, markedly impairing the glucagon response to activation of these nerves. In this study, we sought evidence that this degree of disease-induced nerve terminal damage affected their neuronal cell bodies. Increased galanin expression was used as a marker of the change of phenotype that occurs in neuronal cell bodies when their axons are severely damaged. The celiac ganglion (CG) was analyzed because it is a major source of the sympathetic nerves that project to the pancreatic islets. But we first needed to determine if damaging nerve terminals could increase galanin expression in this ganglion and, if so, when that expression was maximal. Severe, global nerve terminal damage produced a dramatic increase of CG galanin expression which was maximal 5 days later. We next determined if a global, but partial, nerve terminal loss would also increase galanin expression and found a significant increase of galanin mRNA and its peptide in the CG. Finally, we determined if the disease-induced, partial and islet-selective loss of nerve terminals seen in BB diabetic rats was sufficient to increase galanin: we, again, found a significant increase of galanin mRNA and its peptide in their CG. These increases did not occur in their superior cervical ganglia. We conclude that the selective damage to islet sympathetic nerve terminals seen in BB diabetic rats, rather than the systemic factors of diabetic hyperglycemia or insulin deficiency, causes the increased galanin expression observed in the CG of this animal model of type 1 diabetes.


  • Galanin
  • Ganglia
  • Islets of Langerhans
  • Messenger
  • Oxidopamine
  • Rats: Inbred BB
  • Reverse transcription polymerase chain reaction
  • RNA
  • Sympathetic
  • Type 1 Diabetes Mellitus


  • ISSN: 0143-4179
E-mail: ake [dot] lernmark [at] med [dot] lu [dot] se

Principal investigator

Diabetes and Celiac Unit

+46 40 39 19 01

+46 70 616 47 79


Jan Waldenströms gata 35, Malmö


Lund University Diabetes Centre, CRC, SUS Malmö, Jan Waldenströms gata 35, House 91:12. SE-214 28 Malmö. Telephone: +46 40 39 10 00