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Åke Lernmark

Principal investigator

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TEDDY- The environmental determinants of diabetes in the young - An observational clinical trial

Author

  • William A. Hagopian
  • Åke Lernmark
  • Marian J. Rewers
  • Olli G. Simell
  • Jin-Xiong She
  • Anette G. Ziegler
  • Jeffrey P. Krischer
  • Beena Akolkar

Summary, in English

The aim of the TEDDY study is to identify infectious agents, dietary factors, or other environmental agents, including psychosocial factors, which may either trigger islet autoimmunity, type 1 diabetes mellitus (T1DM), or both. The study has two end points: (a) appearance of islet autoantibodies and (b) clinical diagnosis of T1DM. Six clinical centers screen newborns for high-risk HLA genotypes. As of December 2005 a total of 54,470 newborns have been screened. High-risk HLA genotypes among 53,560 general population (GP) infants were 2576 (4.8%) and among 910 newborns with a first-degree relative (FDR) were 194 (21%). A total of 1061 children have been enrolled. The initial enrollment results demonstrate the feasibility of this complex and demanding a prospective study.

Department/s

  • Diabetes and Celiac Unit

Publishing year

2006

Language

English

Pages

320-326

Publication/Series

Annals of the New York Academy of Sciences

Volume

1079

Document type

Journal article

Publisher

Wiley-Blackwell

Topic

  • Endocrinology and Diabetes

Keywords

  • type 1 diabetes
  • islet autoantibodies
  • HLA
  • virus

Status

Published

Research group

  • Diabetes and Celiac Unit

ISBN/ISSN/Other

  • ISSN: 0077-8923