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TEDDY- The environmental determinants of diabetes in the young - An observational clinical trial

  • William A. Hagopian
  • Åke Lernmark
  • Marian J. Rewers
  • Olli G. Simell
  • Jin-Xiong She
  • Anette G. Ziegler
  • Jeffrey P. Krischer
  • Beena Akolkar
Publishing year: 2006
Language: English
Pages: 320-326
Publication/Series: Annals of the New York Academy of Sciences
Volume: 1079
Document type: Journal article
Publisher: New York Academy of Sciences

Abstract english

The aim of the TEDDY study is to identify infectious agents, dietary factors, or other environmental agents, including psychosocial factors, which may either trigger islet autoimmunity, type 1 diabetes mellitus (T1DM), or both. The study has two end points: (a) appearance of islet autoantibodies and (b) clinical diagnosis of T1DM. Six clinical centers screen newborns for high-risk HLA genotypes. As of December 2005 a total of 54,470 newborns have been screened. High-risk HLA genotypes among 53,560 general population (GP) infants were 2576 (4.8%) and among 910 newborns with a first-degree relative (FDR) were 194 (21%). A total of 1061 children have been enrolled. The initial enrollment results demonstrate the feasibility of this complex and demanding a prospective study.


  • Endocrinology and Diabetes
  • type 1 diabetes
  • islet autoantibodies
  • HLA
  • virus


  • Diabetes and Celiac Unit
  • ISSN: 0077-8923
E-mail: ake [dot] lernmark [at] med [dot] lu [dot] se

Principal investigator

Diabetes and Celiac Unit

+46 40 39 19 01

+46 70 616 47 79


Jan Waldenströms gata 35, Malmö


Lund University Diabetes Centre, CRC, SUS Malmö, Jan Waldenströms gata 35, House 91:12. SE-214 28 Malmö. Telephone: +46 40 39 10 00