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Residual beta cell function at diagnosis of type 1 diabetes in children and adolescents varies with gender and season

  • U. Samuelsson
  • B. Lindblad
  • Annelie Carlsson
  • G. Forsander
  • Sten Ivarsson
  • I. Kockum
  • Åke Lernmark
  • C. Marcus
  • J. Ludvigsson
Publishing year: 2013
Language: English
Pages: 85-89
Publication/Series: Diabetes/Metabolism Research Reviews
Volume: 29
Issue: 1
Document type: Journal article
Publisher: John Wiley & Sons

Abstract english

Background There are seasonal variations and gender differences in incidence of type 1 diabetes (T1D), metabolic control and responses to immune interventions at onset of the disease. We hypothesized that there are seasonal and gender differences in residual insulin secretion already at diagnosis of T1D. Methods In 2005, a national study, the Better Diabetes Diagnosis, was started to classify all newly diagnosed children and adolescents with diabetes. About 95% (3824/4017) of the patients were classified as T1D, and our analyses are based on the patients with T1D. Results C-peptide was lower in younger children, 010 years of age (0.23 +/- 0.20 nmol/L) than in older children, 1118 years of age (0.34 +/- 0.28 nmol/L) (p < 0.000 ). There was a seasonal variation in non-fasting serum C-peptide, significantly correlated to the seasonal variation of diagnosis (p < 0.01). Most children were diagnosed in January, February and March as well as in October when C-peptide was highest, whereas fewer patients were diagnosed in April and May when serum C-peptide was significantly lower (p < 0.01). The seasonal variation of C-peptide was more pronounced in boys than in girls (p < 0.000 and p < 0.01, respectively). Girls had higher C-peptide than boys (p < 0.05), especially in early puberty. Conclusions Both seasonal and gender differences in residual beta cell function exist already at diagnosis of T1D. These observations have consequences for treatment and for randomizing patients in immune intervention clinical trials. Copyright (C) 2012 John Wiley & Sons, Ltd.


  • Endocrinology and Diabetes
  • C-peptide
  • children
  • type 1 diabetes
  • seasonal variation
  • gender
  • immune
  • intervention


  • Paediatric Endocrinology
  • Diabetes and Celiac Unit
  • ISSN: 1520-7552
E-mail: ake [dot] lernmark [at] med [dot] lu [dot] se

Principal investigator

Diabetes and Celiac Unit

+46 40 39 19 01

+46 70 616 47 79


Jan Waldenströms gata 35, Malmö


Lund University Diabetes Centre, CRC, SUS Malmö, Jan Waldenströms gata 35, House 91:12. SE-214 28 Malmö. Telephone: +46 40 39 10 00