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Åke Lernmark

Principal investigator

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Glucagon and insulin release from the allografted canine pancreas

Author

  • H. Brynger
  • G. Claes
  • Lernmark

Summary, in English

Six previously pancreatectomized dogs were transplanted with ductligated, pancreatic allografts. Glucagon and insulin levels in the venous outflow from the graft and in the systemic circulation were determined during the first 60 minutes after transplantation. Two of the dogs were subjected to L-arginine stimulation 5 days after transplantation and the glucagon levels in the venous outflow from the graft were determined. The glucagon and insulin concentrations increased rapidly after transplantation, describing a biphasic curve. In response to L-arginine stimulation, an increased glucagon release was observed.

Publishing year

1975-01-01

Language

English

Pages

170-180

Publication/Series

European Surgical Research

Volume

7

Issue

3

Document type

Journal article

Publisher

Karger

Keywords

  • Glucagon release
  • Insulin release
  • l-Arginine stimulation
  • Pancreas transplantation

Status

Published

ISBN/ISSN/Other

  • ISSN: 0014-312X