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Neuropeptide Y is a minor autoantigen in newly diagnosed type 1 diabetes patients.

Author:
  • Hanna Skärstrand
  • Fariba Vaziri Sani
  • Ahmed Delli
  • Carina Törn
  • Helena Larsson
  • Sten Ivarsson
  • Daniel Agardh
  • Åke Lernmark
Publishing year: 2015
Language: English
Pages: 621-628
Publication/Series: Pediatric Diabetes
Volume: 16
Issue: 8
Document type: Journal article
Publisher: Wiley-Blackwell

Abstract english

Autoantibodies (A) against Neuropeptide Y (NPY), was reported in 9% newly diagnosed type 1 diabetes (T1D) patients. A single nucleotide polymorphism (SNP) at rs16139 (T1128C) within the NPY-gene identified an amino acid substitution from leucine (L) to proline (P) (L7P) associated with both glucose tolerance and type 2 diabetes. We aimed to determine: (i) the influence of autoantibodies to leucine neuropeptide Y (NPY-LA) and autoantibodies to proline neuropeptide Y (NPY-PA) on the diagnostic sensitivity of type 1 diabetes (T1D), (ii) the association of NPYA with major islet autoantibodies, and (iii) the association of NPYA with HLA-DQ genotypes in newly diagnosed T1D patients.

Keywords

  • Endocrinology and Diabetes
  • Pediatrics

Other

Published
  • Diabetes and Celiac Unit
  • Paediatric Endocrinology
  • ISSN: 1399-543X
E-mail: ake [dot] lernmark [at] med [dot] lu [dot] se

Principal investigator

Diabetes and Celiac Unit

+46 40 39 19 01

+46 70 616 47 79

60:11:015

Jan Waldenströms gata 35, Malmö

33

Lund University Diabetes Centre, CRC, SUS Malmö, Jan Waldenströms gata 35, House 91:12. SE-214 28 Malmö. Telephone: +46 40 39 10 00