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HLA, infections and inflammation in early stages of atherosclerosis in children with type 1 diabetes

Author:
  • Michal Odermarsky
  • Erkki Pesonen
  • Timo Sorsa
  • Åke Lernmark
  • Pirkko Pussinen
  • Petru Liuba
Publishing year: 2018-01
Language: English
Pages: 41-47
Publication/Series: Acta Diabetologica
Volume: 55
Issue: 1
Document type: Journal article
Publisher: Springer

Abstract english

Aims

This prospective study focuses on risk factors for arterial damage in children with type 1 diabetes (T1D).
Methods

Eighty children and adolescents with T1D were investigated twice, approximately 2 years apart, for carotid artery intima-media thickness (cIMT) and compliance (CAC), flow-mediated dilatation (FMD) of the brachial artery, and plasma levels of matrix metalloproteinase (MMP)-8. All subjects were genotyped for HLA. The number of respiratory tract infections (RTI) during the past year was obtained by a questionnaire in 56 patients.
Results

cIMT progression, defined as percentage (%) change of cIMT from baseline, correlated inversely with the % changes of both CAC (p = 0.04, r = − 0.3; n = 62) and FMD (p = 0.03, r = − 0.3; n = 47). In multivariate analysis, RTI frequency correlated significantly with cIMT progression irrespective of age, diabetes duration, BMI, and HbA1c (p = 0.03, r = 0.3). When patients were divided in relation to RTI, the association of DQ2/8 with cIMT progression remained significant in patients with over three infections/year (p = 0.04, r = 0.3). During follow-up, the group of DQ2/8 patients with hsCRP > 1 mg/l showed significantly higher levels of plasma MMP-8 than the non-DQ2/8 group.
Conclusions

The diabetes-risk genotype DQ2/8 and systemic inflammation contribute to pro-atherosclerotic vascular changes in children and adolescents with T1D.

Keywords

  • Cardiac and Cardiovascular Systems
  • Pediatrics
  • Endocrinology and Diabetes

Other

Published
  • Children cardiology
  • Diabetes and Celiac Unit
  • ISSN: 1432-5233
E-mail: ake [dot] lernmark [at] med [dot] lu [dot] se

Principal investigator

Diabetes and Celiac Unit

+46 40 39 19 01

+46 70 616 47 79

60:11:015

Jan Waldenströms gata 35, Malmö

33

Lund University Diabetes Centre, CRC, SUS Malmö, Jan Waldenströms gata 35, House 91:12. SE-214 28 Malmö. Telephone: +46 40 39 10 00