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Åke Lernmark

Principal investigator

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HLA, infections and inflammation in early stages of atherosclerosis in children with type 1 diabetes

Author

  • Michal Odermarsky
  • Erkki Pesonen
  • Timo Sorsa
  • Åke Lernmark
  • Pirkko Pussinen
  • Petru Liuba

Summary, in English

Aims

This prospective study focuses on risk factors for arterial damage in children with type 1 diabetes (T1D).
Methods

Eighty children and adolescents with T1D were investigated twice, approximately 2 years apart, for carotid artery intima-media thickness (cIMT) and compliance (CAC), flow-mediated dilatation (FMD) of the brachial artery, and plasma levels of matrix metalloproteinase (MMP)-8. All subjects were genotyped for HLA. The number of respiratory tract infections (RTI) during the past year was obtained by a questionnaire in 56 patients.
Results

cIMT progression, defined as percentage (%) change of cIMT from baseline, correlated inversely with the % changes of both CAC (p = 0.04, r = − 0.3; n = 62) and FMD (p = 0.03, r = − 0.3; n = 47). In multivariate analysis, RTI frequency correlated significantly with cIMT progression irrespective of age, diabetes duration, BMI, and HbA1c (p = 0.03, r = 0.3). When patients were divided in relation to RTI, the association of DQ2/8 with cIMT progression remained significant in patients with over three infections/year (p = 0.04, r = 0.3). During follow-up, the group of DQ2/8 patients with hsCRP > 1 mg/l showed significantly higher levels of plasma MMP-8 than the non-DQ2/8 group.
Conclusions

The diabetes-risk genotype DQ2/8 and systemic inflammation contribute to pro-atherosclerotic vascular changes in children and adolescents with T1D.

Department/s

  • Children cardiology
  • Paediatrics (Lund)
  • Diabetes and Celiac Unit
  • EXODIAB: Excellence in Diabetes Research in Sweden

Publishing year

2018-01

Language

English

Pages

41-47

Publication/Series

Acta Diabetologica

Volume

55

Issue

1

Document type

Journal article

Publisher

Springer

Topic

  • Cardiac and Cardiovascular Systems
  • Pediatrics
  • Endocrinology and Diabetes

Status

Published

Research group

  • Children cardiology
  • Diabetes and Celiac Unit

ISBN/ISSN/Other

  • ISSN: 1432-5233