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Åke Lernmark

Principal investigator

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Absence of H-2 genetic influence on streptozotocin-induced diabetes in mice

Author

  • H. Kromann
  • M. Christy
  • J. Egeberg
  • Å Lernmark
  • J. Nerup

Summary, in English

Five daily injections of streptozotocin (40 mg/kg) produced a delayed but progressively increasing level of hyperglycaemia in long term studies with male Naval Medical Research Institute mice and C3D2F1 (DBA 2 J male × C3H/ Tif female) F1 hybrid mice. The development of hyperglycaemia was paralleled by decreased amounts of pancreatic immunoreactive insulin as well as degranulation and necrosis of pancreatic B cells. Insulitis was found from days 9-25 after the first injection of streptozotocin. Compared with the F1 hybrid strain the parental inbred strains DBA 2 J and C3H/Tif demonstrated a certain resistance to streptozotocin. Development of hyperglycaemia did not differ in four congenic resistant lines of mice on the C57 BL/10 genetic background, indicating that major histocompatibility complex genes are not likely to determine susceptibility to streptozotocin-induced islet B cell damage.

Publishing year

1982-08-01

Language

English

Pages

114-118

Publication/Series

Diabetologia

Volume

23

Issue

2

Document type

Journal article

Publisher

Springer

Keywords

  • experimental diabetes
  • H-2 system
  • insulitis
  • Mouse
  • sex hormone
  • streptozotocin

Status

Published

ISBN/ISSN/Other

  • ISSN: 0012-186X