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Åke Lernmark

Principal investigator

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Human class II major histocompatibility antigen β-chains are derived from at least three loci

Author

  • Jan Böhme
  • David Owerbach
  • Maurizio Denaro
  • Åke Lernmark
  • Per A. Peterson
  • Lars Rask

Summary, in English

Class II antigens of the major histocompatibility complex (MHC) consist of two glycosylated, membrane-integrated polypeptide chains1. These cell surface-expressed molecules are involved in several immunobiological events involving cell-cell interactions2,3, most of which seem to require that genetically identical class II antigens, or other molecules controlled by the same region of the MHC, are expressed on the interacting cells4. The extensive genetic polymorphism of the class II antigens5 has rendered analyses in the human system of the number of non-allelic species of class II antigens difficult, although several laboratories have reported the existence of at least two types of human class II antigens6-9. Here we present the results of experiments using restriction enzyme digestions and separation of DNA from individuals homozygous for the MHC followed by hybridization to human class II antigen α-10,11 and β-12-14 chain cDNA probes. While the α -chain probe gave only a single hybridization band, the various β -chain probes revealed a more complex pattern that is consistent with the existence of at least three separate β -chain genes or pseudogenes in the human MHC.

Publishing year

1983-12-01

Language

English

Pages

82-84

Publication/Series

Nature

Volume

301

Issue

5895

Document type

Journal article (letter)

Publisher

Nature Publishing Group

Topic

  • Immunology in the medical area

Status

Published

ISBN/ISSN/Other

  • ISSN: 0028-0836