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Åke Lernmark

Principal investigator

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VERANDERUNG DER INSULINSEKRETION ISOLIERTER LANGERHANS'SCHER INSELN DURCH BEHANDLUNG MIT NEURAMINIDASE

Changes in insulin secretion from pancreatic islets following treatment with neuraminidase

Author

  • H. J. Hahn
  • B. Hellman
  • A. Lernmark
  • I. B. Taljedal

Summary, in English

Treatment of pancreatic islets from ob/ob-mice with bacterial neuraminidase (0.8 to 40 mU/ml) resulted in a significant decrease of the sialic acid content and of the secretory response to glucose. The inhibitory effect on the glucose stimulated insulin release was reproduced with different batches of neuraminidase from Clostridium perfringens and Vibrio cholera. Treatment with neuraminidase affected neither the insulin content of the islets nor the potentiating effect of theophylline in the presence of 20 mM glucose. The results suggest that sialic acid plays a role in the mechanism of insulin release and that the inhibitory effect of sialic acid depletion is overcome by theophylline. (30 references.)

Publishing year

1974-01-01

Language

German

Pages

375-383

Publication/Series

Acta Biologica et Medica Germanica

Volume

32

Issue

4

Document type

Journal article

Publisher

Akademie Verlag GMBH

Status

Published

ISBN/ISSN/Other

  • ISSN: 0001-5318