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High plasma levels of islet amyloid polypeptide in young with new-onset of type 1 diabetes mellitus.

Author:
  • Johan F Paulsson
  • Johnny Ludvigsson
  • Annelie Carlsson
  • Rosaura Casas
  • Gun Forsander
  • Sten Ivarsson
  • Ingrid Kockum
  • Åke Lernmark
  • Claude Marcus
  • Bengt Lindblad
  • Gunilla T Westermark
Publishing year: 2014
Language: English
Publication/Series: PLoS ONE
Volume: 9
Issue: 3
Document type: Journal article
Publisher: Public Library of Science

Abstract english

Islet amyloid polypeptide (IAPP) is a beta cell hormone secreted together with insulin upon glucose stimulation. IAPP participates in normal glucose regulation, but IAPP is also known for its ability to misfold and form islet amyloid. Amyloid fibrils form through smaller cell toxic intermediates and deposited amyloid disrupts normal islet architecture. Even though IAPP and amyloid formation are much discussed in type 2 diabetes, our aim was to study the significance of IAPP in type 1 diabetes.

Keywords

  • Endocrinology and Diabetes
  • Pediatrics

Other

Published
  • Paediatric Endocrinology
  • Diabetes and Celiac Unit
  • Vascular Diseases - Clinical Research
  • ISSN: 1932-6203
E-mail: ake [dot] lernmark [at] med [dot] lu [dot] se

Principal investigator

Diabetes and Celiac Unit

+46 40 39 19 01

+46 70 616 47 79

60:11:015

Jan Waldenströms gata 35, Malmö

33

Lund University Diabetes Centre, CRC, SUS Malmö, Jan Waldenströms gata 35, House 91:12. SE-214 28 Malmö. Telephone: +46 40 39 10 00