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Åke Lernmark

Principal investigator

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Content of adenosine 3′:5′-cyclic monophosphate in the pancreatic islets of mice with a hereditary defect of insulin secretion

Author

  • Lennart Boquist
  • Bo Hellman
  • Åke Lernmark
  • Inge Bert Täljedal

Summary, in English

Glucose (20 mM) released insulin from pancreatic islets of C57BL 6J- db2J db2J mice, the response being potentiated by 1 mM 3-isobutyl-1-methylxanthine. Islets of C57BL KsJ- db db mice failed to respond to glucose and released only little insulin when challenged with both glucose and methylxanthine. After incubation with 0 or 20 mM glucose alone the islet content of adenosine 3′:5′-cyclic monophosphate did not differ between the two types of mice or between glucose concentrations. 3-Isobutyl-1-methylxanthine increased the islet adenosine 3′:5′-cyclic monophosphate markedly in 6J- db2J db2J mice but not significantly in KsJ- db db mice.

Publishing year

1974-10-23

Language

English

Pages

1391-1396

Publication/Series

Biochemical and Biophysical Research Communications

Volume

60

Issue

4

Document type

Journal article

Publisher

Elsevier

Status

Published

ISBN/ISSN/Other

  • ISSN: 0006-291X