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Development of type 1 diabetes in wild bank voles associated with islet autoantibodies and the novel ljungan virus.

Author:
  • Bo Niklasson
  • Knud E Heller
  • Bryan Schønecker
  • Mogens Bildsøe
  • Terri Daniels
  • Christiane S Hampe
  • Per Widlund
  • William T Simonson
  • Jonathan B Schaefer
  • Elizabeth Rutledge
  • Lynn Bekris
  • A Michael Lindberg
  • Susanne Johansson
  • Eva Ortqvist
  • Bengt Persson
  • Åke Lernmark
Publishing year: 2003
Language: English
Pages: 35-44
Publication/Series: International journal of experimental diabesity research
Volume: 4
Issue: 1
Document type: Journal article
Publisher: Taylor & Francis

Abstract english

Wild bank voles (Clethrionomys glareolus) may develop diabetes in laboratory captivity. The aim of this study was to test whether bank voles develop type 1 diabetes in association with Ljungan virus. Two groups of bank voles were analyzed for diabetes, pancreas histology, autoantibodies to glutamic acid decarboxylase (GAD65), IA-2, and insulin by standardized radioligand-binding assays as well as antibodies to in vitro transcribed and translated Ljungan virus antigens. Group A represented 101 trapped bank voles, which were screened for diabetes when euthanized within 24 hours of capture. Group B represented 67 bank voles, which were trapped and kept in the laboratory for 1 month before being euthanized. Group A bank voles did not have diabetes. Bank voles in group B (22/67; 33%) developed diabetes due to specific lysis of pancreatic islet beta cells. Compared to nondiabetic group B bank voles, diabetic animals had increased levels of GAD65 (P < .0001), IA-2 (P < .0001), and insulin (P

Keywords

  • Endocrinology and Diabetes

Other

Published
  • Diabetes and Celiac Unit
E-mail: ake [dot] lernmark [at] med [dot] lu [dot] se

Principal investigator

Diabetes and Celiac Unit

+46 40 39 19 01

+46 70 616 47 79

60:11:015

Jan Waldenströms gata 35, Malmö

33

Lund University Diabetes Centre, CRC, SUS Malmö, Jan Waldenströms gata 35, House 91:12. SE-214 28 Malmö. Telephone: +46 40 39 10 00