Your browser has javascript turned off or blocked. This will lead to some parts of our website to not work properly or at all. Turn on javascript for best performance.

The browser you are using is not supported by this website. All versions of Internet Explorer are no longer supported, either by us or Microsoft (read more here: https://www.microsoft.com/en-us/microsoft-365/windows/end-of-ie-support).

Please use a modern browser to fully experience our website, such as the newest versions of Edge, Chrome, Firefox or Safari etc.

Default user image.

Åke Lernmark

Principal investigator

Default user image.

Development of type 1 diabetes in wild bank voles associated with islet autoantibodies and the novel ljungan virus.

Author

  • Bo Niklasson
  • Knud E Heller
  • Bryan Schønecker
  • Mogens Bildsøe
  • Terri Daniels
  • Christiane S Hampe
  • Per Widlund
  • William T Simonson
  • Jonathan B Schaefer
  • Elizabeth Rutledge
  • Lynn Bekris
  • A Michael Lindberg
  • Susanne Johansson
  • Eva Ortqvist
  • Bengt Persson
  • Åke Lernmark

Summary, in English

Wild bank voles (Clethrionomys glareolus) may develop diabetes in laboratory captivity. The aim of this study was to test whether bank voles develop type 1 diabetes in association with Ljungan virus. Two groups of bank voles were analyzed for diabetes, pancreas histology, autoantibodies to glutamic acid decarboxylase (GAD65), IA-2, and insulin by standardized radioligand-binding assays as well as antibodies to in vitro transcribed and translated Ljungan virus antigens. Group A represented 101 trapped bank voles, which were screened for diabetes when euthanized within 24 hours of capture. Group B represented 67 bank voles, which were trapped and kept in the laboratory for 1 month before being euthanized. Group A bank voles did not have diabetes. Bank voles in group B (22/67; 33%) developed diabetes due to specific lysis of pancreatic islet beta cells. Compared to nondiabetic group B bank voles, diabetic animals had increased levels of GAD65 (P < .0001), IA-2 (P < .0001), and insulin (P

Department/s

  • Diabetes and Celiac Unit

Publishing year

2003

Language

English

Pages

35-44

Publication/Series

International journal of experimental diabesity research

Volume

4

Issue

1

Document type

Journal article

Publisher

Taylor & Francis

Topic

  • Endocrinology and Diabetes

Status

Published

Research group

  • Diabetes and Celiac Unit