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Åke Lernmark

Principal investigator

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Islet Cell Cytoplasmic Antibodies (ICA) in Diabetes and Disorders of Glucose Tolerance

Author

  • B. Marner
  • G. Bille
  • M. Christy
  • E. M. Damsgaard
  • S. Garne
  • E. Heinze
  • S. Larsen
  • Å Lernmark
  • T. Mandrup‐Poulsen
  • J. Nerup
  • M. Schroll

Summary, in English

Islet cell cytoplasmic antibodies were determined in 85 individuals 60 to 74 years old with fasting hyperglycaemia, in 65 patients with cystic fibrosis, in 113 patients with pancreatitis, in 21 patients with Turner's phenotype, and in 135 first‐degree relatives of patients with Type 1 (insulin‐dependent) diabetes. Islet cell antibodies were absent in all 60 to 74‐year‐old subjects with fasting hyperglycaemia detected by screening, and who did not require insulin treatment within 3 years. Islet cell antibodies were also absent in all patients with pancreatitis, cystic fibrosis, or Turner's phenotype. Islet cell antibodies were detected in 2 out of 135 (1.5 %) first‐degree relatives of new Type 1 diabetic patients, and in 1 out of 371 (0.3%) non‐diabetic control subjects. During 12 years of follow‐up 1 of the 2 first‐degree relatives with islet cell antibodies and the only positive control developed Type 1 diabetes. It is suggested that islet cell antibodies are primarily associated with Type 1 diabetes and not with other disorders of glucose tolerance. 1991 Diabetes UK

Publishing year

1991-01-01

Language

English

Pages

812-816

Publication/Series

Diabetic Medicine

Volume

8

Issue

9

Document type

Journal article

Publisher

Wiley-Blackwell

Topic

  • Endocrinology and Diabetes

Keywords

  • Cystic fibrosis
  • Diabetes mellitus
  • Family history
  • Islet cell antibodies
  • Pancreatitis
  • Relatives
  • Turner's syndrome

Status

Published

ISBN/ISSN/Other

  • ISSN: 0742-3071