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Åke Lernmark

Principal investigator

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Interleukin-1 potentiates glucose stimulated insulin release in the isolated perfused pancreas

Author

  • L. D. Wogensen
  • T. Mandrup-Poulsen
  • H. Markholst
  • J. Molvig
  • A. Lernmark
  • J. J. Holst
  • C. A. Dinarello
  • J. Nerup

Summary, in English

The acute effects of recombinant human interleukin-1 beta (rIL-1) on basal and glucose-stimulated insulin release were investigated in the isolated perfused pancreas. At a concentration of 20 μg/l rIL-1 had no effect on basal insulin release, but increased the total amount of insulin released during first and second phase insulin release in response to 20 mmol/l D-glucose in the rat pancreas (P < 0.05). In addition, 26 μg/l of rIL-1 potentiated insulin release in response to square wave infusions of stimulatory concentrations of glucose (11 mmol/l) in the porcine pancreas. We hypothesize that IL-1 in the systemic circulation may affect B cell function in vivo.

Publishing year

1988-01-01

Language

English

Pages

302-306

Publication/Series

Acta Endocrinologica

Volume

117

Issue

3

Document type

Journal article

Publisher

Society of the European Journal of Endocrinology

Status

Published

ISBN/ISSN/Other

  • ISSN: 0001-5598