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Åke Lernmark

Principal investigator

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Staging Presymptomatic Type 1 Diabetes: A Scientific Statement of JDRF, the Endocrine Society, and the American Diabetes Association.

Author

  • Richard A Insel
  • Jessica L Dunne
  • Mark A Atkinson
  • Jane L Chiang
  • Dana Dabelea
  • Peter A Gottlieb
  • Carla J Greenbaum
  • Kevan C Herold
  • Jeffrey P Krischer
  • Åke Lernmark
  • Robert E Ratner
  • Marian J Rewers
  • Desmond A Schatz
  • Jay S Skyler
  • Jay M Sosenko
  • Anette-G Ziegler

Summary, in English

Insights from prospective, longitudinal studies of individuals at risk for developing type 1 diabetes have demonstrated that the disease is a continuum that progresses sequentially at variable but predictable rates through distinct identifiable stages prior to the onset of symptoms. Stage 1 is defined as the presence of β-cell autoimmunity as evidenced by the presence of two or more islet autoantibodies with normoglycemia and is presymptomatic, stage 2 as the presence of β-cell autoimmunity with dysglycemia and is presymptomatic, and stage 3 as onset of symptomatic disease. Adoption of this staging classification provides a standardized taxonomy for type 1 diabetes and will aid the development of therapies and the design of clinical trials to prevent symptomatic disease, promote precision medicine, and provide a framework for an optimized benefit/risk ratio that will impact regulatory approval, reimbursement, and adoption of interventions in the early stages of type 1 diabetes to prevent symptomatic disease.

Department/s

  • Diabetes and Celiac Unit
  • EXODIAB: Excellence in Diabetes Research in Sweden

Publishing year

2015

Language

English

Pages

1964-1974

Publication/Series

Diabetes Care

Volume

38

Issue

10

Document type

Journal article

Publisher

American Diabetes Association

Topic

  • Endocrinology and Diabetes

Status

Published

Research group

  • Diabetes and Celiac Unit

ISBN/ISSN/Other

  • ISSN: 1935-5548