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Åke Lernmark

Principal investigator

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Nonislet pancreatic autoantibodies in sibship with permanent neonatal insulin-dependent diabetes mellitus

Author

  • S. A. Ivarsson
  • B. Marner
  • A. Lernmark
  • K. O. Nilsson

Summary, in English

Neonatal insulin-dependent diabetes mellitus (IDDM) occurs rarely. A sibship of two HLA-Dw314-positive boys who developed IDDM within the 1st wk of life is described. Although the HLA-D region genotype would be consistent with IDDM associated with islet autoimmunity, islet cell antibodies were negative, but both boys exhibited the presence of a novel autoantibody that reacted specifically with a conspicuous, yet unidentified, determinant in the interstitial tissue among the acinar cells. The possible relationship between this acinar nonislet autoantibody and permanent neonatal diabetes remains to be established.

Publishing year

1988-01-01

Language

English

Pages

347-350

Publication/Series

Diabetes

Volume

37

Issue

3

Document type

Journal article

Publisher

American Diabetes Association Inc.

Status

Published

ISBN/ISSN/Other

  • ISSN: 0012-1797