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Åke Lernmark

Principal investigator

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Specificity of cyclic AMP potentiation of glucose-stimulated insulin release

Author

  • Åke Lernmark

Summary, in English

The insulin-releasing activities of cyclic and non-cyclic nucleotides were studied with isolated pancreatic islets from obese-hyperglycemic mice. Substitution of cylidine, inosine, guanosine, or uridine for the adenosine moeity of cyclic 3ʹ,5ʹ-adenosine monophosphate was associated with a total loss of insulin-releasing ability. The 5ʹ-nucleotide triphosphate derivatives of these nucleotides were all ineffective. It is suggested that cyclic AMP potentiation of glucose-stimulated insulin release in the mouse is highly specific for this nucleotide.

Publishing year

1974-01-01

Language

English

Pages

227-233

Publication/Series

Hormone Research in Paediatrics

Volume

5

Issue

4

Document type

Journal article

Publisher

Karger

Topic

  • Endocrinology and Diabetes

Keywords

  • Cyclic AMP
  • Cyclic mononucleotides
  • Insulin release
  • Isolated islets

Status

Published

ISBN/ISSN/Other

  • ISSN: 1663-2818