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Åke Lernmark

Principal investigator

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The influence of the major histocompatibility complex (H-2) on experimental diabetes in mice

Author

  • H. Kromann
  • Å Lernmark
  • B. F. Vestergaard
  • J. Egeberg
  • J. Nerup

Summary, in English

Mice with different histocompatibility loci on an identical background genome (congenic resistant lines of mice) were used to study the possible influence of the histocompatibility complex on experimental diabetes. The major histocompatibility complex (H-2) was not found to influence the diabetogenic effect of encephalomyocarditis (EMC) virus. In contrast the glucose intolerance following heterologous and homologous immunization with pancreatic antigens appeared H-2 influenced. Antibodies against cell surface components on viable B-cells were present in serum from mice with glucose intolerance induced by homologous immunization. The results suggest that the susceptibility to experimental autoimmune diabetes in mice is influenced by the H-2 complex.

Publishing year

1979-02-01

Language

English

Pages

107-114

Publication/Series

Diabetologia

Volume

16

Issue

2

Document type

Journal article

Publisher

Springer

Keywords

  • autoimmunity
  • Experimental diabetes mellitus
  • glucose intolerance
  • immune response genes
  • islet-cell-surface antibody
  • major histocompatibility locus
  • virus

Status

Published

ISBN/ISSN/Other

  • ISSN: 0012-186X