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Åke Lernmark

Principal investigator

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Effects of insulin secretagogues on phospholipid metabolism in pancreatic β-cells

Author

  • G. Fex
  • A. Lernmark

Summary, in English

The effect of insulin secretagogues on the incorporation of [32P]ortho-phosphate into phospholipids was studied in microdissected islets from obese-hyperglycemic mice. Increased 32P-labelling was observed after incubation for 60 min with 10 mM l-leucine, 10 mM l-arginine or 20 mM d-glucose. Most of the label occurred in the phosphatidyl inositol fraction. The effect of l-leucine was additive to that induced by d-glucose while the effect of l-arginine was not. Glibenclamide (0.05 mM) was ineffective whether or not d-glucose was present. The results suggest that there is no direct correlation between the releasing actions of insulin secretagogues and changes in the metabolism of certain phospholipids and that phospholipid metabolism may be stimulated through more than one mechanism.

Publishing year

1975-04-18

Language

English

Pages

1-4

Publication/Series

Biochimica et Biophysica Acta - Lipids and Lipid Metabolism

Volume

388

Issue

1

Document type

Journal article

Publisher

Elsevier

Topic

  • Endocrinology and Diabetes

Status

Published

ISBN/ISSN/Other

  • ISSN: 0005-2760