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Åke Lernmark

Principal investigator

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Glutamate decarboxylase antibody levels predict rate of β-cell decline in adult-onset diabetes

Author

  • A. Gottsäter
  • M. Landin-Olsson
  • Å Lernmark
  • P. Fernlund
  • G. Sundkvist
  • W. A. Hagopian

Summary, in English

Glutamate decarboxylase autoantibodies (GAD65Ab) and β-cell function were evaluated at and 3 years after diabetes onset in consecutive subjects over 15 years of age. At onset, 21 32 (66%) insulin-treated patients (mean age 43, range 16-79 years) had GAD65Ab; all GAD65Ab persisted 3 years later. At onset, 20 82 (24%) non-insulin-treated patients (mean age 56, range 20-79 years) had GAD65Ab. Of those with persistent GAD65Ab, 8 non-insulin-treated and 11 insulin-treated patients consented to follow-up glucose and glucagon stimulation tests. For non-insulin-treated patients, quantitative GAD65Ab index at onset correlated inversely with 1+3 min C-peptide response to glucose (r = -0.68, P < 0.05) and to glucagon (r = -0.79, P < 0.05) 3 years later. Those with high (> 0.50) initial GAD65Ab index had lower C-peptide (fasting, 1+3 min after glucose and after glucagon) 3 years later, versus those with low (<0.50) initial GAD65Ab index (P < 0.05). In conclusion, not only did GAD65Ab presence predict future insulin dependence, but higher GAD65Ab levels may mark more rapid decline in β-cell function in apparent non-insulin-dependent diabetes.

Department/s

  • Vascular Diseases - Clinical Research
  • Faculty of Medicine
  • Diabetes lab
  • Medicine, Lund
  • Diabetes and Celiac Unit
  • Clinical Chemistry, Malmö
  • Department of Clinical Sciences, Malmö

Publishing year

1995-01-01

Language

English

Pages

133-140

Publication/Series

Diabetes Research and Clinical Practice

Volume

27

Issue

2

Document type

Journal article

Publisher

Elsevier

Topic

  • Endocrinology and Diabetes

Keywords

  • Autoantigen
  • Autoimmunity
  • Glutamate decarboxylase (GAD)
  • β-Cell function

Status

Published

Research group

  • Vascular Diseases - Clinical Research
  • Diabetes lab
  • Diabetes and Celiac Unit
  • Clinical Chemistry, Malmö

ISBN/ISSN/Other

  • ISSN: 0168-8227