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Åke Lernmark

Principal investigator

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Prevalence of β-cell and Thyroid Autoantibody Positivity in Schoolchildren during Three-Year Follow-up

Author

  • Bengt Lindberg
  • Annelie Carlsson
  • Ulla-Britt Ericsson
  • Ingrid Kockum
  • Åke Lernmark
  • Mona Landin-Olsson
  • Göran Sundkvist
  • Sten-Anders Ivarsson

Summary, in English

The prevalence of autoantibodies against the 65 kD isoform of glutamic acid decarboxylase (GAD65Ab), insulin (IAA), islet cells (ICA), thyroid peroxidase (TPOAb) and thyroglob-ulin (TgAb), in relation to HLA-DR types, was assessed in 310 (HLA in 280) twelve-year-old children during three-year follow-up. Altogether, 26.8% (83?10) of the children were found to carry at least one autoantibody. The HLA-DR3/DR4 genotype was significantly more prevalent in the subgroup of children GAD65Ab-positive on at least one occasion than among GAD65Ab-negative children |33% (2/6) vs. 5% (12/274);? = 0.03|, as was the HLA-DR4/x genotype among children seropositive for at least one thyroid autoantibody, compared to the corresponding seronegative subgroup [52% (34/65) vs. 34% (74/215); p = 0.01]. The proportion of children seropositive in at least one of the three tests was 1.9% (6?10) for GAD65Ab, 2.6% (8?10) for IAA, 5.2% (16?10) for ICA, 11.3% (35?10) for TPOAb and 19.4% (60?10) for TgAb. All autoantibodies except GAD65Ab tended to disappear during follow-up, and at the three-year follow-up IAA had disappeared in 50% (2/4) of cases, ICA in 67% (6/9), TPOAb in 30% (6/20) and TgAb in 38% (18/47) of cases. The turnover of seropositive subjects and the large proportion of children seropositive for at least one islet or thyroid autoantibody during a three-year follow-up suggest transient autoantibodies to be more common than is discernible in cross-sectional investigations

Department/s

  • Paediatrics (Lund)
  • PediatricCeliaki/Diabetes
  • Medicine, Lund
  • Diabetes lab
  • Department of Clinical Sciences, Malmö
  • Paediatric Endocrinology

Publishing year

1999-01-01

Language

English

Pages

175-185

Publication/Series

Autoimmunity

Volume

31

Issue

3

Document type

Journal article

Publisher

Taylor & Francis

Topic

  • Rheumatology and Autoimmunity

Status

Published

Research group

  • PediatricCeliaki/Diabetes
  • Diabetes lab
  • Paediatric Endocrinology

ISBN/ISSN/Other

  • ISSN: 0891-6934