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Åke Lernmark

Principal investigator

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Identification of an HLA-DQ β-chain related genomic sequence associated with insulin-dependent diabetes

Author

  • B. Michelsen
  • W. Kastern
  • A. Lernmark
  • D. Owerbach

Summary, in English

Restriction fragment length polymorphism detected by a cDNA probe for an HLA-DQ β-chain gene has revealed an HLA-DR4 linked BamH1 3.7 kb fragment which is rarely found among insulin-dependent diabetic patients. The present analysis demonstrates that the BamH1 3.7 kb fragment present on an HLA-DR4 positive chromosome in a healthy individual contains coding sequences for an HLA-DQ β-chain gene and that the absence of this fragment among HLA-DR4 positive insulin-dependent patients is due to the loss of a BamH1 restriction within an intervening sequence.

Publishing year

1985-01-01

Language

English

Pages

33-36

Publication/Series

Biomedica Biochimica Acta

Volume

44

Issue

1

Document type

Journal article

Publisher

Akademie Verlag

Status

Published

ISBN/ISSN/Other

  • ISSN: 0232-766X