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Åke Lernmark

Principal investigator

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Immunoglobulin from insulin-dependent diabetic children inhibits glucose-induced insulin release

Author

  • T. Kanatsuna
  • S. Baekkeskov
  • A. Lernmark
  • J. Ludvigsson

Summary, in English

Immunoglobulin was separated from islet cel antibody positive plasma of six children with newly diagnosed insulin-dependent (type I) diabetes mellitus. The dynamics of insulin release in response to glucose and partially purified antibodies were determined in dispersed rat islet cells perifused on small columns of Biogel P-2 beads. After perifusion at 5.5 mmol/L D-glucose in the presence of healthy control immunoglobulin, the rate of insulin release increased in a biphasic manner after stimulation with 30 mmol/L D-glucose. In cells exposed to diabetic immunoglobulin, 30 mmol/L D-glucose had little, if any, effect on insulin release. These results suggest that islet cell antibodies in insulin-dependent diabetes may interfere with the insulin release mechanisms in the pancreatic B-cells.

Publishing year

1983-01-01

Language

English

Pages

520-524

Publication/Series

Diabetes

Volume

32

Issue

6 I

Document type

Journal article

Publisher

American Diabetes Association Inc.

Status

Published

ISBN/ISSN/Other

  • ISSN: 0012-1797