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Islet autoantibodies and residual beta cell function in type 1 diabetes children followed for 3-6 years

Author:
  • J. S. Sorensen
  • Fariba Vaziri Sani
  • M. Maziarz
  • K. Kristensen
  • A. Ellerman
  • N. Breslow
  • Åke Lernmark
  • F. Pociot
  • C. Brorsson
  • N. H. Birkebaek
Publishing year: 2012
Language: English
Pages: 204-210
Publication/Series: Diabetes Research and Clinical Practice
Volume: 96
Issue: 2
Document type: Journal article
Publisher: Elsevier

Abstract english

Aims: To test if islet autoantibodies at diagnosis of type 1 diabetes (T1DM) and after 3-6 years with T1D predict residual beta-cell function (RBF) after 3-6 years with T1D. Methods: T1D children (n = 260, median age at diagnosis 9.4, range 0.9-14.7 years) were tested for GAD65, IA-2, ZnT8R, ZnT8W and ZnT8Q autoantibodies (A) at diagnosis, and 3-6 years after diagnosis when also fasting and stimulated RBF were determined. Results: For every 1-year increase in age at diagnosis of TID, the odds of detectable C-peptide increased 1.21 (1.09, 1.34) times for fasting C-peptide and 1.28 (1.15, 1.42) times for stimulated C-peptide. Based on a linear model for subjects with no change in IA-2A levels, the odds of detectable C-peptide were 35% higher than for subjects whose IA-2A levels decreased by half (OR = 1.35 (1.09, 1.67), p = 0.006); similarly for ZnT8WA (OR = 1.39 (1.09, 1.77), p = 0.008) and ZnT8QA (OR = 1.55 (1.06, 2.26) p = 0.024). Such relationship was not detected for GADA or ZnT8RA. All OR adjusted for confounders. Conclusions: Age at diagnosis with T1D was the major predictor of detectable C-peptide 3-6 years post-diagnosis. Decreases in IA-2A, and possibly ZnT8A, levels between diagnosis and post-diagnosis were associated with a reduction in RBF post-diagnosis. (C) 2012 Elsevier Ireland Ltd. All rights reserved.

Keywords

  • Endocrinology and Diabetes
  • GAD65 autoantibodies
  • IA-2 autoantibodies
  • ZnT8 autoantibodies
  • Residual
  • beta cell function
  • Age at diagnosis

Other

Published
  • Diabetes and Celiac Unit
  • ISSN: 1872-8227
E-mail: ake [dot] lernmark [at] med [dot] lu [dot] se

Principal investigator

Diabetes and Celiac Unit

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+46 70 616 47 79

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Jan Waldenströms gata 35, Malmö

33

Lund University Diabetes Centre, CRC, SUS Malmö, Jan Waldenströms gata 35, House 91:12. SE-214 28 Malmö. Telephone: +46 40 39 10 00