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Åke Lernmark

Principal investigator

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Detection and possible functional influence of antibodies directed againt the pancreatic islet cell surface.

Author

  • A. Lernmark
  • T. Kanatsuna
  • A. H. Rubenstein
  • D. F. Steiner

Summary, in English

Antibodies directed towards determinants on the surface of rat islet cells can be detected qualitatively by the indirect immunofluorescence or quantitatively by a specific radioassay for IgG. Antibodies are found in insulin-dependent diabetics or in rabbits immunized with islet cells. Such antibodies may affect the B-cell function as indicated by the inhibition of incorporation of radioactive leucine into proinsulin/insulin in vitro.

Publishing year

1979-01-01

Language

English

Pages

157-163

Publication/Series

Advances in Experimental Medicine and Biology

Volume

119

Document type

Journal article

Publisher

Springer

Status

Published

ISBN/ISSN/Other

  • ISSN: 0065-2598