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Åke Lernmark

Principal investigator

Contact details
Organisation
  • Celiac Disease and Diabetes Unit
  • Visiting address: Jan Waldenströms gata 35, Malmö
  • Room number: 60:11:015
  • Service point: 33
Webpage
Other affiliations
  • Principal investigator
    EXODIAB: Excellence of Diabetes Research in Sweden

Immunogenetics of Type 1 Diabetes

The HLA DQ locus is the major genetic risk factor for both type 1 diabetes and celiac disease.  Both diseases are also linked to several non−HLA candidate genes, which may modify risk. Several but different etiological factors in the environment have also been implicated in the disease risk for type 1 diabetes and celiac disease. The pathogenesis of type 1 diabetes is strongly associated with the appearance of autoantibodies against GAD65, IA−2, ZnT8 and insulin, alone or in combination. Our laboratory cloned human islet GAD65 and developed a novel assay now in worldwide use to detect these autoantibodies and other autoantibodies such as those against tissue transglutaminase that predict celiac disease.

Publications

Displaying of publications. Sorted by year, then title.