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Åke Lernmark

Immunogenetics of Type 1 Diabetes

The HLA DQ locus is the major genetic risk factor for both type 1 diabetes and celiac disease. Both diseases are also linked to several non−HLA candidate genes, which may modify risk. Several but different etiological factors in the environment have also been implicated in the disease risk for type 1 diabetes and celiac disease. The pathogenesis of type 1 diabetes is strongly associated with the appearance of autoantibodies against GAD65, IA−2, ZnT8 and insulin, alone or in combination. Our laboratory cloned human islet GAD65 and developed a novel assay now in worldwide use to detect these autoantibodies and other autoantibodies such as those against tissue transglutaminase that predict celiac disease.

Publications

Retrieved from Lund University's publications database

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Publications

Retrieved from Lund University's publications database

2019
- Rationale for enteroviral vaccination and antiviral therapies in human type 1 diabetes
  Jessica L. Dunne, Sarah J. Richardson, Mark A. Atkinson, Maria E. Craig, Knut Dahl-Jørgensen, et al.
  (2019) Diabetologia
  Journal article
- Time-resolved autoantibody profiling facilitates stratification of preclinical type 1 diabetes in children
  , David Endesfelder, Wolfgang zu Castell, Ezio Bonifacio, Marian Rewers, et al.
  (2019) Diabetes
  Journal article
2018
- 10 år med BDD-studien har gett bättre diabetesdiagnos hos barn : Studiens analysbatteri är nu klinisk rutin och kunskapen om olika diabetessjukdomar har ökat
  Annelie Carlsson, Gun Forsander, Sten Ivarsson, Helena Elding Larsson, Åke Lernmark, et al.
  (2018) Lakartidningen
  Journal article
- Caesarean Section on The Risk of Celiac Disease in the Offspring : The Teddy Study
  Sibylle Koletzko, Hye-Seung Lee, Andreas Beyerlein, Carin A. Aronsson, Michael Hummel, et al.
  (2018) Journal of Pediatric Gastroenterology and Nutrition
  Journal article
- Early deficits in insulin secretion, beta cell mass and islet blood perfusion precede onset of autoimmune type 1 diabetes in BioBreeding rats
  Anya Medina, Saba Parween, Sara Ullsten, Neelanjan Vishnu, Yuk Ting Siu, et al.
  (2018) Diabetologia
  Journal article
- Early infant diet and islet autoimmunity in the TEDDY study
  Ulla Uusitalo, Hye Seung Lee, Carin Andrén Aronsson, Kendra Vehik, Jimin Yang, et al.
  (2018) Diabetes Care
  Journal article
- First trimester enterovirus IgM and beta cell autoantibodies in mothers to children affected by type 1 diabetes autoimmunity before 7 years of age
  Alexander Lind, Kristian F. Lynch, Markus Lundgren, Åke Lernmark, Peter Almgren, et al.
  (2018) Journal of Reproductive Immunology
  Journal article
- Genetic risk scores in adult-onset type 1 diabetes
  Richard David Leslie, Åke Lernmark
  (2018) The Lancet Diabetes and Endocrinology
  Journal article (letter)
- Genetic scores to stratify risk of developing multiple islet autoantibodies and type 1 diabetes : A prospective study in children
  Ezio Bonifacio, Andreas Beyerlein, Markus Hippich, Christiane Winkler, Kendra Vehik, et al.
  (2018) PLoS Medicine
  Journal article
- Gestational respiratory infections interacting with offspring HLA and CTLA-4 modifies incident β-cell autoantibodies
  Kristian F. Lynch, Hye-Seung Lee, Carina Törn, Kendra Vehik, Jeffrey P. Krischer, et al.
  (2018) Journal of Autoimmunity
  Journal article
- HLA, infections and inflammation in early stages of atherosclerosis in children with type 1 diabetes
  Michal Odermarsky, Erkki Pesonen, Timo Sorsa, Åke Lernmark, Pirkko Pussinen, et al.
  (2018) Acta Diabetologica
  Journal article
- Identification of non-HLA genes associated with development of islet autoimmunity and type 1 diabetes in the prospective TEDDY cohort
  Ashok Sharma, Xiang Liu, David Hadley, William Hagopian, Wei Min Chen, et al.
  (2018) Journal of Autoimmunity
  Journal article
- Maternal dietary supplement use and development of islet autoimmunity in the offspring : TEDDY study
  , Katherine Silvis, Carin A. Aronsson, Xiang Liu, Ulla Uusitalo, et al.
  (2018) Pediatric Diabetes
  Journal article
- Novel subgroups of adult-onset diabetes and their association with outcomes : A data-driven cluster analysis of six variables
  Emma Ahlqvist, Petter Storm, Annemari Käräjämäki, Mats Martinell, Mozhgan Dorkhan, et al.
  (2018) The Lancet Diabetes and Endocrinology
  Journal article
- Pandemrix® vaccination is not associated with increased risk of islet autoimmunity or type 1 diabetes in the TEDDY study children
  Helena Elding Larsson, Kristian F. Lynch, Maria Lönnrot, Michael J Haller, Åke Lernmark, et al.
  (2018) Diabetologia
  Journal article
- Plasma 25-Hydroxyvitamin D concentration and risk of islet autoimmunity
  Jill M. Norris, Hye Seung Lee, Brittni Frederiksen, Iris Erlund, Ulla Uusitalo, et al.
  (2018) Diabetes
  Journal article
- Progression from islet autoimmunity to clinical type 1 diabetes is influenced by genetic factors : Results from the prospective TEDDY study
  , Andreas Beyerlein, Ezio Bonifacio, Kendra Vehik, Markus Hippich, et al.
  (2018) Journal of Medical Genetics
  Journal article
- Reduced display of conformational epitopes in the N-terminal truncated GAD65 isoform : relevance for people with stiff person syndrome or DQ8/8-positive Type 1 diabetes mellitus
  C. S. Hampe, J. R. Radtke, A. Wester, A. Carlsson, E. Cedervall, et al.
  (2018) Diabetic Medicine
  Journal article
- Reduction in White Blood Cell, Neutrophil, and Red Blood Cell Counts Related to Sex, HLA, and Islet Autoantibodies in Swedish TEDDY Children at Increased Risk for Type 1 Diabetes
  , Falastin Salami, Hye Seung Lee, Eva Freyhult, Helena Elding Larsson, et al.
  (2018) Diabetes
  Journal article
- Temporal development of the gut microbiome in early childhood from the TEDDY study
  Christopher J. Stewart, Nadim J. Ajami, Jacqueline L. O’Brien, Diane S. Hutchinson, Daniel P. Smith, et al.
  (2018) Nature
  Journal article (letter)
- The Better Diabetes Diagnosis (BDD) study – A review of a nationwide prospective cohort study in Sweden
  M. Persson, C. Becker, H. Elding Larsson, Lernmark, G. Forsander, et al.
  (2018) Diabetes Research and Clinical Practice
  Journal article review
- The Environmental Determinants of Diabetes in the Young (TEDDY) Study: 2018 Update
  , Heikki Hyöty, Åke Lernmark, William Hagopian, Jin-Xiong She, et al.
  (2018) Current Diabetes Reports
  Journal article
- The human gut microbiome in early-onset type 1 diabetes from the TEDDY study
  Tommi Vatanen, Eric A. Franzosa, Randall Schwager, Surya Tripathi, Timothy D. Arthur, et al.
  (2018) Nature
  Journal article (letter)
- Tissue transglutaminase autoantibodies in children with newly diagnosed type 1 diabetes are related to human leukocyte antigen but not to islet autoantibodies : A Swedish nationwide prospective population-based cohort study
  Mara Cerqueiro Bybrant, Lena Grahnquist, Eva Örtqvist, Cecilia Andersson, Gun Forsander, et al.
  (2018) Autoimmunity
  Journal article
2017
- An Increased Diagnostic Sensitivity of Truncated GAD65 Autoantibodies in Type 1 Diabetes May Be Related to HLA-DQ8
  Axel Wester, Hanna Skärstrand, Alexander Lind, Anita Ramelius, Annelie Carlsson, et al.
  (2017) Diabetes
  Journal article
- Analgesic antipyretic use among young children in the TEDDY study : No association with islet autoimmunity
  Markus Lundgren, Leigh Johnson Steed, Roy N. Tamura, Berglind Jonsdottir, Patricia Gesualdo, et al.
  (2017) BMC Pediatrics
  Journal article
- Antibody Affinity Against 2009 A/H1N1 Influenza and Pandemrix Vaccine Nucleoproteins Differs Between Childhood Narcolepsy Patients and Controls
  Alexander Lind, Eva Freyhult, Anita Ramelius, Tomas Olsson, Lisen Arnheim-Dahlström, et al.
  (2017) Viral Immunology
  Journal article
- Association Between Early-Life Antibiotic Use and the Risk of Islet or Celiac Disease Autoimmunity
  Kaisa M Kemppainen, Kendra Vehik, Kristian F Lynch, Helena Elding Larsson, Ronald J Canepa, et al.
  (2017) JAMA Pediatrics
  Journal article
- Building and validating a prediction model for paediatric type 1 diabetes risk using next generation targeted sequencing of class II HLA genes
  Lue Ping Zhao, Annelie Carlsson, Helena Elding Larsson, Gun Forsander, Sten A Ivarsson, et al.
  (2017) Diabetes/Metabolism Research and Reviews
  Journal article
- Co-occurrence of Type 1 Diabetes and Celiac Disease Autoimmunity
  William Hagopian, Hye Seung Lee, Edwin Liu, Marian Rewers, Jin Xiong She, et al.
  (2017) Pediatrics
  Journal article
- Different DRB1*03 : 01-DQB1*02:01 haplotypes confer different risk for celiac disease
  S. Alshiekh, L. P. Zhao, Lernmark, Daniel E Geraghty, Asa T Naluai, et al.
  (2017) HLA
  Journal article
- Early prediction of autoimmune (type 1) diabetes
  Simon E. Regnell, Åke Lernmark
  (2017) Diabetologia
  Journal article
- Factors That Increase Risk of Celiac Disease Autoimmunity After a Gastrointestinal Infection in Early Life
  Kaisa M Kemppainen, Kristian F. Lynch, Edwin Liu, Maria Lönnrot, Ville Simell, et al.
  (2017) Clinical Gastroenterology and Hepatology
  Journal article
- First infant formula type and risk of islet autoimmunity in the environmental determinants of diabetes in the young (TEDDY) study
  Sandra Hummel, Andreas Beyerlein, Roy N. Tamura, Ulla Uusitalo, Carin Andŕen Aronsson, et al.
  (2017) Diabetes Care
  Journal article
- Genetic and environmental interactions modify the risk of diabetes-related autoimmunity by 6 years of age : The teddy study
  Jeffrey P. Krischer, Kristian F Lynch, Ake Lernmark, William A Hagopian, Marian J. Rewers, et al.
  (2017) Diabetes Care
  Journal article
- Islet autoantibodies present in association with Ljungan virus infection in bank voles (Myodes glareolus) in northern Sweden
  Anna Warvsten, Martin Björnfors, Michael Arvidsson, Fariba Vaziri-Sani, Ida Jönsson, et al.
  (2017) Journal of Medical Virology
  Journal article
- Joint modeling of longitudinal autoantibody patterns and progression to type 1 diabetes : results from the TEDDY study
  Meike Köhler, Andreas Beyerlein, Kendra Vehik, Sonja Greven, Nikolaus Umlauf, et al.
  (2017) Acta Diabetologica
  Journal article
- Longitudinal analysis of hepatic transcriptome and serum metabolome demonstrates altered lipid metabolism following the onset of hyperglycemia in spontaneously diabetic BioBreeding rats
  Simon E. Regnell, Martin J Hessner, Shuang Jia, Lina Åkesson, Hans Stenlund, et al.
  (2017) PLoS ONE
  Journal article
- Maternal use of dietary supplements during pregnancy is not associated with coeliac disease in the offspring : The Environmental Determinants of Diabetes in the Young (TEDDY) study
  Jimin Yang, Roy N. Tamura, Carin Andrén Aronsson, Ulla M Uusitalo, Åke Lernmark, et al.
  (2017) British Journal of Nutrition
  Journal article
- Psychological manifestations of celiac disease autoimmunity in young children
  Laura B. Smith, Kristian Lynch, Kalle Kurppa, Sibylle Koletzko, Jeffrey Krischer, et al.
  (2017) Pediatrics
  Journal article
- Residual beta-cell function in diabetes children followed and diagnosed in the TEDDY study compared to community controls
  Andrea K Steck, Helena Elding Larsson, Xiang Liu, Riitta Veijola, Jorma Toppari, et al.
  (2017) Pediatric Diabetes
  Journal article
- Respiratory infections are temporally associated with initiation of type 1 diabetes autoimmunity : the TEDDY study
  Maria Lönnrot, Kristian F. Lynch, Helena Elding Larsson, Åke Lernmark, Marian J. Rewers, et al.
  (2017) Diabetologia
  Journal article
- The Influence of Type 1 Diabetes Genetic Susceptibility Regions, Age, Sex, and Family History to the Progression from Multiple Autoantibodies to Type 1 Diabetes:A TEDDY Study Report : A TEDDY Study Report
  Jeffrey P. Krischer, Xiang Liu, Åke Lernmark, William A. Hagopian, Marian J. Rewers, et al.
  (2017) Diabetes
  Journal article
- The feasibility of salivary sample collection in an international pediatric cohort : The the TEDDY study
  Roswith Roth, Judith Baxter, Kendra Vehik, Diane Hopkins, Michael Killian, et al.
  (2017) Developmental Psychobiology
  Journal article
- Thyroid and islet autoantibodies predict autoimmune thyroid disease already at Type 1 diabetes diagnosis
  Berglind Jonsdottir, Christer Larsson, Annelie Carlsson, Gun Forsander, Sten Anders Ivarsson, et al.
  (2017) The Journal of clinical endocrinology and metabolism
  Journal article
- Type 1 diabetes mellitus
  Anastasia Katsarou, Soffia Gudbjörnsdottir, Araz Rawshani, Dana Dabelea, Ezio Bonifacio, et al.
  (2017) Nature Reviews Disease Primers
  Journal article
- Understanding and preventing type 1 diabetes through the unique working model of TrialNet
  Manuela Battaglia, Mark S Anderson, Jane H. Buckner, Susan M. Geyer, Peter A Gottlieb, et al.
  (2017) Diabetologia
  Journal article
2016
- A Comparison of Rule-based Analysis with Regression Methods in Understanding the Risk Factors for Study Withdrawal in a Pediatric Study
  Mona Haghighi, Suzanne Bennett Johnson, Xiaoning Qian, Kristian F. Lynch, Kendra Vehik, et al.
  (2016) Scientific Reports
  Journal article
- Altered regulatory T cell phenotype in latent autoimmune diabetes of the adults (LADA)
  M. Radenkovic, C. Silver, J. Arvastsson, K. Lynch, Åke Lernmark, et al.
  (2016) Clinical and Experimental Immunology
  Journal article
- An Object-Oriented Regression for Building Disease Predictive Models with Multiallelic HLA Genes
  Lue Ping Zhao, Hamid Bolouri, Michael Zhao, Daniel E. Geraghty, Åke Lernmark
  (2016) Genetic Epidemiology
  Journal article
- Complement gene variants in relation to autoantibodies to beta cell specific antigens and type 1 diabetes in the TEDDY Study
  Carina Törn, Xiang Liu, William Hagopian, Åke Lernmark, Olli Simell, et al.
  (2016) Scientific Reports
  Journal article
- Diabetes at the crossroads: relevance of disease classification to pathophysiology and treatment.
  R David Leslie, Jerry Palmer, Nanette C Schloot, Åke Lernmark
  (2016) Diabetologia
  Journal article review
- Effects of Gluten Intake on Risk of Celiac Disease: a case-control study on a Swedish birth cohort.
  Carin Andrén Aronsson, Hye-Seung Lee, Sibylle Koletzko, Ulla Uusitalo, Jimin Yang, et al.
  (2016) Clinical Gastroenterology and Hepatology
  Journal article
- Environmental factors in the etiology of type 1 diabetes, celiac disease, and narcolepsy
  Åke Lernmark
  (2016) Pediatric Diabetes
  Journal article review
- Genetic risk factors for type 1 diabetes
  Flemming Pociot, Åke Lernmark
  (2016) The Lancet
  Journal article
- Growth and risk for islet autoimmunity and progression to type 1 diabetes in early childhood : The environmental determinants of diabetes in the young study
  Helena Elding Larsson, Kendra Vehik, Michael J. Haller, Xiang Liu, Beena Akolkar, et al.
  (2016) Diabetes
  Journal article
- Identification of Non-HLA Genes Associated with Celiac Disease and Country-Specific Differences in a Large, International Pediatric Cohort
  Ashok Sharma, Xiang Liu, David Hadley, William Hagopian, Edwin Liu, et al.
  (2016) PLoS ONE
  Journal article
- Increased DNA methylation variability in type 1 diabetes across three immune effector cell types
  Dirk S. Paul, Andrew E. Teschendorff, Mary A N Dang, Robert Lowe, Mohammed I. Hawa, et al.
  (2016) Nature Communications
  Journal article
- Next generation sequencing reveals that HLA-DRB3, -DRB4 and -DRB5 may be associated with islet autoantibodies and risk for childhood type 1 diabetes.
  Lue Ping Zhao, Shehab Alshiekh, Annelie Carlsson, Helena Larsson, Gun Forsander, et al.
  (2016) Diabetes
  Journal article
- Pancreas volume and fat fraction in children with Type 1 diabetes
  SIMON ERINGSMARK REGNÉLL, P Peterson, L Trinh, P Broberg, P Leander, et al.
  (2016) Diabetic Medicine
  Journal article
- Reversion of β-cell autoimmunity changes risk of type 1 diabetes : TEDDY study
  Kendra Vehik, Kristian F. Lynch, Desmond A. Schatz, Beena Akolkar, William Hagopian, et al.
  (2016) Diabetes Care
  Journal article
- Type 1 Diabetes
  Åke Lernmark, Shehab Alshiekh
  (2016)
  Book chapter
2015
- A Functional Polymorphism of Ptpn22 Is Associated with Type 1 Diabetes in the BioBreeding Rat.
  Janice Sarmiento, Robert H Wallis, Terri Ning, Leili Marandi, Gary Chao, et al.
  (2015) Journal of Immunology
  Journal article
- A method for reporting and classifying acute infectious diseases in a prospective study of young children: TEDDY
  Maria Lönnrot, Kristian Lynch, Helena Larsson, Åke Lernmark, Marian Rewers, et al.
  (2015) BMC Pediatrics
  Journal article
- Association of Early Exposure of Probiotics and Islet Autoimmunity in the TEDDY Study.
  Ulla Uusitalo, Xiang Liu, Jimin Yang, Carin Andrén Aronsson, Sandra Hummel, et al.
  (2015) JAMA Pediatrics
  Journal article
- Baseline heterogeneity in glucose metabolism marks the risk for type 1 diabetes and complicates secondary prevention.
  Helena Larsson, Christer Larsson, Åke Lernmark
  (2015) Acta Diabetologica
  Journal article
- Cell-surface MHC density profiling reveals instability of autoimmunity-associated HLA
  Hiroko Miyadera, Jun Ohashi, Åke Lernmark, Toshio Kitamura, Katsushi Tokunaga
  (2015) Journal of Clinical Investigation
  Journal article
- Determination of 21-hydroxylase autoantibodies: inter-laboratory concordance in the Euradrenal International Serum Exchange Program
  Alberto Falorni, Vittorio Bini, Corrado Betterle, Annalisa Brozzetti, Luis Castano, et al.
  (2015) Clinical Chemistry and Laboratory Medicine
  Journal article
- Dietary intake of soluble fiber and risk of islet autoimmunity by 5 y of age: results from the TEDDY study.
  Andreas Beyerlein, Xiang Liu, Ulla M Uusitalo, Minna Harsunen, Jill M Norris, et al.
  (2015) American Journal of Clinical Nutrition
  Journal article
- Doubly reactive INS-IGF2 autoantibodies in children with newly diagnosed autoimmune (type 1) diabetes.
  Norio Kanatsuna, Ahmed Delli, Cecilia K Andersson, Anna-Lena Nilsson, Fariba Vaziri Sani, et al.
  (2015) Scandinavian Journal of Immunology
  Journal article
- Early Childhood Gut Microbiomes Show Strong Geographic Differences Among Subjects at High Risk for Type 1 Diabetes.
  Kaisa M Kemppainen, Alexandria N Ardissone, Austin G Davis-Richardson, Jennie R Fagen, Kelsey A Gano, et al.
  (2015) Diabetes Care
  Journal article
- Elevated Serum GAD65 and GAD65-GADA Immune Complexes in Stiff Person Syndrome.
  Gucci Jijuan Gu Urban, Mikaela Friedman, Ping Ren, Carina Törn, Malin Fex, et al.
  (2015) Scientific Reports
  Journal article
- Factors associated with longitudinal food record compliance in a paediatric cohort study.
  Jimin Yang, Kristian F Lynch, Ulla M Uusitalo, Kristina Foterek, Sandra Hummel, et al.
  (2015) Public Health Nutrition
  Journal article
- Immunology of β-Cell Destruction
  Åke Lernmark, DARIA LA TORRE, MARKUS LUNDGREN, Helena Larsson
  (2015)
  Book chapter
- Magnetic resonance imaging reveals altered distribution of hepatic fat in children with type 1 diabetes compared to controls.
  Simon Regnell, Pernilla Peterson, Lena Trinh, Per Broberg, Peter Leander, et al.
  (2015) Metabolism, Clinical and Experimental
  Journal article
- Neuropeptide Y is a minor autoantigen in newly diagnosed type 1 diabetes patients.
  Hanna Skärstrand, Fariba Vaziri Sani, Ahmed Delli, Carina Törn, Helena Larsson, et al.
  (2015) Pediatric Diabetes
  Journal article
- Non-HLA type 1 diabetes genes modulate disease risk together with HLA-DQ and islet autoantibodies.
  M Maziarz, W Hagopian, J P Palmer, C B Sanjeevi, I Kockum, et al.
  (2015) Genes and Immunity
  Journal article
- Plasma GAD65, a Marker for Early beta-Cell Loss After Intraportal Islet Cell Transplantation in Diabetic Patients
  Zhidong Ling, Pieter De Pauw, Daniel Jacobs-Tulleneers-Thevissen, Rui Mao, Pieter Gillard, et al.
  (2015) Journal of Clinical Endocrinology and Metabolism
  Journal article
- Predictors of Progression From the Appearance of Islet Autoantibodies to Early Childhood Diabetes: The Environmental Determinants of Diabetes in the Young (TEDDY).
  Andrea K Steck, Kendra Vehik, Ezio Bonifacio, Åke Lernmark, Anette-G Ziegler, et al.
  (2015) Diabetes Care
  Journal article
- Prevalence of celiac disease autoimmunity in children with type 1 diabetes: regional variations across the Øresund strait between Denmark and southernmost Sweden.
  Emma Adlercreutz, Jannet Svensson, Dorthe Hansen, Karsten Buschard, Åke Lernmark, et al.
  (2015) Pediatric Diabetes
  Journal article
- Role of Type 1 diabetes associated SNPs on risk of autoantibody positivity in the TEDDY Study.
  Carina Törn, David Hadley, Hye-Seung Lee, William Hagopian, Åke Lernmark, et al.
  (2015) Diabetes
  Journal article
- Serological evaluation of possible exposure to Ljungan virus and related parechovirus in autoimmune (type 1) diabetes in children.
  Anna-Lena Nilsson, Fariba Vaziri Sani, Per Broberg, A Elfaitouri, R Pipkorn, et al.
  (2015) Journal of Medical Virology
  Journal article
- Staging Presymptomatic Type 1 Diabetes: A Scientific Statement of JDRF, the Endocrine Society, and the American Diabetes Association.
  Richard A Insel, Jessica L Dunne, Mark A Atkinson, Jane L Chiang, Dana Dabelea, et al.
  (2015) Diabetes Care
  Journal article
- The 6 year incidence of diabetes-associated autoantibodies in genetically at-risk children: the TEDDY study
  Jeffrey P. Krischer, Kristian F. Lynch, Desmond A. Schatz, Jorma Ilonen, Åke Lernmark, et al.
  (2015) Diabetologia
  Journal article
- The streetlight effect-is there light at the end of the tunnel?
  Åke Lernmark
  (2015) Diabetes
  Journal article (comment)
- ZnT8 autoantibody epitope specificity and affinity examined with recombinant ZnT8 variant proteins in specific ZnT8R and ZnT8W autoantibody positive type 1 diabetes patients.
  Hanna Skärstrand, Ewa Krupinska, Tatu Haataja, Fariba Vaziri Sani, Jens Lagerstedt, et al.
  (2015) Clinical and Experimental Immunology
  Journal article
2014
- A/H1N1 antibodies and TRIB2 autoantibodies in narcolepsy patients diagnosed in conjunction with the Pandemrix vaccination campaign in Sweden 2009-2010.
  Alexander Lind, Anita Ramelius, Tomas Olsson, Lisen Arnheim-Dahlström, Favelle Lamb, et al.
  (2014) Journal of Autoimmunity
  Journal article
- Activating germline mutations in STAT3 cause early-onset multi-organ autoimmune disease.
  Sarah E Flanagan, Emma Haapaniemi, Mark A Russell, Richard Caswell, Hana Lango Allen, et al.
  (2014) Nature Genetics
  Journal article
- Antibodies to influenza virus A/H1N1 hemagglutinin in type 1 diabetes children diagnosed before, during and after the Swedish A(H1N1)pdm09 vaccination campaign 2009-2010.
  Matilda1 Svensson, Anita Ramelius, Anna-Lena Nilsson, Ahmed Delli, Helena Larsson, et al.
  (2014) Scandinavian Journal of Immunology
  Journal article
- Biomarker discovery study design for type 1 diabetes in The Environmental Determinants of Diabetes in the Young (TEDDY) study
  Hye-Seung Lee, Brant R. Burkhardt, Wendy McLeod, Susan Smith, Chris Eberhard, et al.
  (2014) Diabetes/Metabolism Research Reviews
  Journal article
- Carl-David Agardh, 1946-2013.
  Leif Groop, Åke Lernmark, Jan Nilsson
  (2014) Diabetologia
  Journal article
- Children followed in the TEDDY study are diagnosed with type 1 diabetes at an early stage of disease.
  Helena Larsson, Kendra Vehik, Patricia Gesualdo, Beena Akolkar, William Hagopian, et al.
  (2014) Pediatric Diabetes
  Journal article
- GAD Autoantibody Affinity in Adult Patients With Latent Autoimmune Diabetes, the Study Participants of a GAD65 Vaccination Trial
  Stephanie Krause, Ulrike Landherr, Carl-David Agardh, Simone Hausmann, Katarina Link, et al.
  (2014) Diabetes Care
  Journal article
- High plasma levels of islet amyloid polypeptide in young with new-onset of type 1 diabetes mellitus.
  Johan F Paulsson, Johnny Ludvigsson, Annelie Carlsson, Rosaura Casas, Gun Forsander, et al.
  (2014) PLoS ONE
  Journal article
- Islet cell antibodies (ICA) identify autoimmunity in children with new onset diabetes mellitus negative for other islet cell antibodies.
  Cecilia K Andersson, Martin Kolmodin, Sten Ivarsson, Annelie Carlsson, Gun Forsander, et al.
  (2014) Pediatric Diabetes
  Journal article
- Lack of evidence for a role of islet autoimmunity in the aetiology of canine diabetes mellitus.
  Kerstin M Ahlgren, Tove Fall, Nils Landegren, Lars Grimelius, Henrik von Euler, et al.
  (2014) PLoS ONE
  Journal article
- Prevalence of obesity was related to HLA-DQ in 2-4-year-old children at genetic risk for type 1 diabetes.
  J Yang, Åke Lernmark, U M Uusitalo, K F Lynch, R Veijola, et al.
  (2014) International Journal of Obesity
  Journal article
- Reduced morbidity at diagnosis and improved glycemic control in children previously enrolled in DiPiS follow-up
  Markus Lundgren, Åsa Sahlin, Camilla Svensson, Annelie Carlsson, Elisabeth Cedervall, et al.
  (2014) Pediatric Diabetes
  Journal article
- Type 1 (Insulin-Dependent) Diabetes Mellitus
  Ahmed Delli, Åke Lernmark
  (2014)
  Book chapter
- Variability in the CIITA gene interacts with HLA in multiple sclerosis.
  A Gyllenberg, F Piehl, L Alfredsson, J Hillert, I L Bomfim, et al.
  (2014) Genes and Immunity
  Journal article
2013
- Autoimmune (type 1) diabetes
  Ahmed Delli, Åke Lernmark
  (2013)
  Book chapter
- Autoimmunity against INS-IGF2 expressed in human pancreatic islets.
  Norio Kanatsuna, Jalal Taneera, Fariba Vaziri Sani, Nils Wierup, Helena Larsson, et al.
  (2013) Journal of Biological Chemistry
  Journal article
- Biobreeding rat islets exhibit reduced antioxidative defense and N-acetyl cysteine treatment delays type 1 diabetes
  Marika Bogdani, Angela M. Henschel, Sanjay Kansra, Jessica M. Fuller, Rhonda Geoffrey, et al.
  (2013) Journal of Endocrinology
  Journal article
- Decline in Titers of Anti-Idiotypic Antibodies Specific to Autoantibodies to GAD65 (GAD65Ab) Precedes Development of GAD65Ab and Type 1 Diabetes.
  Helena Larsson, Ida Jönsson, Åke Lernmark, Sten Ivarsson, Jared R Radtke, et al.
  (2013) PLoS ONE
  Journal article
- Decline of C-peptide during the first year after diagnosis of Type 1 diabetes in children and adolescents
  Johnny Ludvigsson, Annelie Carlsson, Ahmed Deli, Gun Forsander, Sten Ivarsson, et al.
  (2013) Diabetes Research and Clinical Practice
  Journal article
- Decreased cord-blood phospholipids in young age at onset type 1 diabetes.
  Daria La Torre, Tulikki Seppänen-Laakso, Helena Larsson, Tuulia Hyötyläinen, Sten Ivarsson, et al.
  (2013) Diabetes
  Journal article
- Depleting T cells in newly diagnosed autoimmune (type 1) diabetes--are we getting anywhere?
  Åke Lernmark
  (2013) Diabetes
  Journal article (comment)
- Glucose tolerance and beta-cell function in islet autoantibody-positive children recruited to a secondary prevention study.
  Cecilia K Andersson, Annelie Carlsson, Corrado Cilio, Elisabeth Cedervall, Sten Ivarsson, et al.
  (2013) Pediatric Diabetes
  Journal article
- Immune therapy in type 1 diabetes mellitus.
  Åke Lernmark, Helena Larsson
  (2013) Nature Reviews Endocrinology
  Journal article
- Is there evidence for post-translational modification of beta cell autoantigens in the aetiology and pathogenesis of type 1 diabetes?
  Åke Lernmark
  (2013) Diabetologia
  Journal article
- Meta-Immunological Profiling of Children With Type 1 Diabetes Identifies New Biomarkers to Monitor Disease Progression
  Mario Galgani, Rosa Nugnes, Dario Bruzzese, Francesco Perna, Veronica De Rosa, et al.
  (2013) Diabetes
  Journal article
- Methods, quality control and specimen management in an international multicentre investigation of type 1 diabetes: TEDDY
  Kendra Vehik, Steven W. Fiske, Chad A. Logan, Daniel Agardh, Corrado Cilio, et al.
  (2013) Diabetes/Metabolism Research Reviews
  Journal article
- Neuropeptide Y autoantibodies in patients with long-term type 1 and type 2 diabetes and neuropathy.
  Hanna Skärstrand, L B Dahlin, Åke Lernmark, Fariba Vaziri Sani
  (2013) Journal of Diabetes and its Complications1992-01-01+01:00
  Journal article
- Next-generation sequencing for viruses in children with rapid-onset type 1 diabetes
  H-S Lee, T. Briese, C. Winkler, M. Rewers, E. Bonifacio, et al.
  (2013) Diabetologia
  Journal article
- Relationship Between Ljungan Virus Antibodies, HLA-DQ8, and Insulin Autoantibodies in Newly Diagnosed Type 1 Diabetes Children
  Anna-Lena Nilsson, Fariba Vaziri Sani, Cecilia K Andersson, Karin Larsson, Annelie Carlsson, et al.
  (2013) Viral Immunology
  Journal article
- Residual beta cell function at diagnosis of type 1 diabetes in children and adolescents varies with gender and season
  U. Samuelsson, B. Lindblad, Annelie Carlsson, G. Forsander, Sten Ivarsson, et al.
  (2013) Diabetes/Metabolism Research Reviews
  Journal article
- Thyroid autoimmunity in relation to islet autoantibodies and HLA-DQ genotype in newly diagnosed type 1 diabetes in children and adolescents.
  Berglind Jonsdottir, Cecilia K Andersson, Annelie Carlsson, Ahmed Delli, G Forsander, et al.
  (2013) Diabetologia
  Journal article
- Triple specificity of ZnT8 autoantibodies in relation to HLA and other islet autoantibodies in childhood and adolescent type 1 diabetes.
  C Andersson, Fariba Vaziri Sani, Aj Delli, Bengt Lindblad, Annelie Carlsson, et al.
  (2013) Pediatric Diabetes
  Journal article
- Viruses, diabetes, and autoimmunity : Studies of subjects at genetic risk for type 1 diabetes
  Sabina Resic Lindehammer, Åke Lernmark
  (2013)
  Book chapter
2012
- Age-dependent variation of genotypes in MHC II transactivator gene (CIITA) in controls and association to type 1 diabetes
  A Gyllenberg, Samina Asad, F Piehl, Maria Swanberg, L Padyukov, et al.
  (2012) Genes and Immunity
  Journal article
- Antigenicity and epitope specificity of ZnT8 autoantibodies in type 1 diabetes.
  Hanna Skärstrand, Åke Lernmark, Fariba Vaziri Sani
  (2012) Scandinavian Journal of Immunology
  Journal article
- Association between autoantibodies to the Arginine variant of the Zinc transporter 8 (ZnT8) and stimulated C-peptide levels in Danish children and adolescents with newly diagnosed type 1 diabetes
  Marie Louise M. Andersen, Fariba Vaziri Sani, Ahmed Delli, Sven Porksen, Emma Jacobssen, et al.
  (2012) Pediatric Diabetes
  Journal article
- BLUEPRINT to decode the epigenetic signature written in blood
  David Adams, Lucia Altucci, Stylianos E. Antonarakis, Juan Ballesteros, Stephan Beck, et al.
  (2012) Nature Biotechnology1996-01-01+01:00
  Journal article (letter)
- C-peptide in the classification of diabetes in children and adolescents.
  Johnny Ludvigsson, Annelie Carlsson, G Forsander, Sten Ivarsson, I Kockum, et al.
  (2012) Pediatric Diabetes
  Journal article
- Few differences in cytokines between patients newly diagnosed with type 1 diabetes and their healthy siblings
  Jannet Svensson, Stefanie Eising, David Michael Hougaard, Henrik Bindesbol Mortensen, Kristin Skogstrand, et al.
  (2012) Human Immunology
  Journal article
- Guthrie card methylomics identifies temporally stable epialleles that are present at birth in humans
  Huriya Beyan, Thomas A. Down, Sreeram V. Ramagopalan, Kristina Uvebrant, Anita Ramelius, et al.
  (2012) Genome Research
  Journal article
- Guías y recomendaciones para el diagnóstico y manejo de la Diabetes Mellitus
  David B. Sacks, Mark Arnold, George L. Bakris, David E. Bruns, Andrea Rita Horvath, et al.
  (2012) Acta Bioquimica Clinica Latinoamericana
  Journal article
- HLA-DQB1 genotypes and islet cell autoantibodies against GAD65 and IA-2 in relation to development of diabetes post partum in women with gestational diabetes mellitus.
  Anastasia Papadopoulou, Kristian Lynch, Eva Anderberg, Mona Landin-Olsson, Ida Jönsson, et al.
  (2012) Diabetes Research and Clinical Practice
  Journal article
- HTR1A a Novel Type 1 Diabetes Susceptibility Gene on Chromosome 5p13-q13
  Samina Asad, Pernilla Nikamo, Alexandra Gyllenberg, Hedvig Bennet, Ola Hansson, et al.
  (2012) PLoS ONE
  Journal article
- High levels of immunoglobulin E and a continuous increase in immunoglobulin G and immunoglobulin M by age in children with newly diagnosed type 1 diabetes
  Jannet Svensson, Stefanie Eising, Henrik Bindesbol Mortensen, Michael Christiansen, Inga Laursen, et al.
  (2012) Human Immunology
  Journal article
- Islet autoantibodies and residual beta cell function in type 1 diabetes children followed for 3-6 years
  J. S. Sorensen, Fariba Vaziri Sani, M. Maziarz, K. Kristensen, A. Ellerman, et al.
  (2012) Diabetes Research and Clinical Practice
  Journal article
- Low risk HLA-DQ and increased body mass index in newly diagnosed type 1 diabetes children in the Better Diabetes Diagnosis study in Sweden.
  Annelie Carlsson, I Kockum, Bengt Lindblad, Lisa Engleson, A Nilsson, et al.
  (2012) International Journal of Obesity
  Journal article
- Seroconversion to Islet Autoantibodies After Enterovirus Infection in Early Pregnancy.
  Sabina Rešić Lindehammer, Hanna Honkanen, William Allan Nix, Maarit Oikarinen, Kristian Lynch, et al.
  (2012) Viral Immunology
  Journal article
- The environment and the origins of islet autoimmunity and Type 1 diabetes.
  S Eringsmark Regnéll, Åke Lernmark
  (2012) Diabetic medicine : a journal of the British Diabetic Association
  Journal article
- Zinc Transporter 8 Autoantibodies and Their Association With SLC30A8 and HLA-DQ Genes Differ Between Immigrant and Swedish Patients With Newly Diagnosed Type 1 Diabetes in the Better Diabetes Diagnosis Study.
  Ahmed Delli, Fariba Vaziri Sani, Bengt Lindblad, Helena Larsson, Annelie Carlsson, et al.
  (2012) Diabetes
  Journal article
2011
- A novel triple mix radiobinding assay for the three ZnT8 (ZnT8-RWQ) autoantibody variants in children with newly diagnosed diabetes.
  Fariba Vaziri Sani, Ahmed Delli, Helena Larsson, Bengt Lindblad, Annelie Carlsson, et al.
  (2011) Journal of Immunological Methods
  Journal article
- BB rat Gimap gene expression in sorted lymphoid T and B cells
  Daniel H. Moralejo, Jessica Fuller, Elizabeth A. Rutledge, Brian Van Yserloo, Ruth A. Ettinger, et al.
  (2011) Life Sciences
  Journal article
- Correlations between islet autoantibody specificity and the SLC30A8 genotype with HLA-DQB1 and metabolic control in new onset type 1 diabetes
  Caroline Brorsson, Fariba Vaziri Sani, Regine Bergholdt, Stefanie Eising, Anita Ramelius, et al.
  (2011) Autoimmunity
  Journal article
- Country-specific birth weight and length in type 1 diabetes high-risk HLA genotypes in combination with prenatal characteristics.
  Y Sterner, Carina Törn, H-S Lee, Helena Larsson, Christian Winkler, et al.
  (2011) Journal of Perinatology
  Journal article
- Danish children born with glutamic acid decarboxylase-65 and islet antigen-2 autoantibodies at birth had an increased risk to develop type 1 diabetes
  Stefanie Eising, Anita Ramelius, Bendix Carstensen, David M. Hougaard, Bent Norgaard-Pedersen, et al.
  (2011) European Journal of Endocrinology1994-01-01+01:00
  Journal article
- Does immune-tolerance treatment with Alum-formulated GAD65 protect insulin-production in the pancreatic islet β cells?
  Helena Elding Larsson, Åke Lernmark
  (2011) Human Vaccines
  Journal article review
- Early-Pregnancy Cytokines in Mothers to Children Developing Multiple, Persistent Islet Autoantibodies, Type 1 Diabetes, or Both Before 7 Years of Age.
  Sabina Lindehammer, Malin Fex, Marlena Maziarz, Ida Hanson, Karel Marsal, et al.
  (2011) American Journal of Reproductive Immunology
  Journal article
- Editorial Comment on type 1 diabetes and antigen-specific immunotherapy.
  Åke Lernmark, H E Larsson
  (2011) Journal of Internal Medicine1989-01-01+01:00
  Journal article (letter)
- Executive Summary: Guidelines and Recommendations for Laboratory Analysis in the Diagnosis and Management of Diabetes Mellitus
  David B. Sacks, Mark Arnold, George L. Bakris, David E. Bruns, Andrea Rita Horvath, et al.
  (2011) Clinical Chemistry
  Journal article (comment)
- Gestational diabetes mellitus is associated with TCF7L2 gene polymorphisms independent of HLA-DQB1*0602 genotypes and islet cell autoantibodies.
  Anastasia Papadopoulou, Kristian Lynch, Nael Shaat, Rasmus Bennet, Sten Ivarsson, et al.
  (2011) Diabetic Medicine
  Journal article
- Guidelines and Recommendations for Laboratory Analysis in the Diagnosis and Management of Diabetes Mellitus
  David B. Sacks, Mark Arnold, George L. Bakris, David E. Bruns, Andrea Rita Horvath, et al.
  (2011) Clinical Chemistry
  Journal article
- Guidelines and recommendations for laboratory analysis in the diagnosis and management of diabetes mellitus
  David B. Sacks, Mark Arnold, George L. Bakris, David E. Bruns, Andrea Rita Horvath, et al.
  (2011) Diabetes Care
  Journal article review
- HLA Genes, Islet Autoantibodies and Residual C-Peptide at the Clinical Onset of Type 1 Diabetes Mellitus and the Risk of Retinopathy 15 Years Later
  Richard A. Jensen, Elisabet Agardh, Åke Lernmark, Soffia Gudbjornsdottir, Nicholas L. Smith, et al.
  (2011) PLoS ONE
  Journal article
- Hepatic steatosis in type 1 diabetes
  Simon Regnell, Åke Lernmark
  (2011) Review of Diabetic Studies
  Journal article review
- High-titer GAD65 autoantibodies detected in adult diabetes patients using a high efficiency expression vector and cold GAD65 displacement.
  Ida Jönsson, Kristian Lynch, Göran Hallmans, Åke Lernmark, Olov Rolandsson
  (2011) Autoimmunity
  Journal article
- Increased GABA(A) channel subunits expression in CD8(+) but not in CD4(+) T cells in BB rats developing diabetes compared to their congenic littermates
  Suresh Kumar Mendu, Lina Åkesson, Zhe Jin, Anna Edlund, Corrado Cilio, et al.
  (2011) Molecular Immunology
  Journal article
- Position Statement Executive Summary: Guidelines and Recommendations for Laboratory Analysis in the Diagnosis and Management of Diabetes Mellitus
  David B. Sacks, Mark Arnold, George L. Bakris, David E. Bruns, Andrea Rita Horvath, et al.
  (2011) Diabetes Care
  Journal article
- Relationship between ZnT8Ab, the SLC30A8 gene and disease progression in children with newly diagnosed type 1 diabetes
  Lotte B. Nielsen, Fariba Vaziri Sani, Sven Poerksen, Marie-Louise M. Andersen, Jannet Svensson, et al.
  (2011) Autoimmunity
  Journal article
- Seroconversion to islet autoantibodies between early pregnancy and delivery in non-diabetic mothers
  Sabina Lindehammer, Ida Jönsson, Bo Midberg, Sten Ivarsson, Kristian Lynch, et al.
  (2011) Journal of Reproductive Immunology
  Journal article
- Serum metabolite signature predicts the acute onset of diabetes in spontaneously diabetic congenic BB rats
  Lina Åkesson, Johan Trygg, Jessica Fuller, Rasmus Madsen, Jon Gabrielsson, et al.
  (2011) Metabolomics
  Journal article
- Sustained glucagon-like peptide 1 expression from encapsulated transduced cells to treat obese diabetic rats
  Daniel H. Moralejo, Ofer Yanay, Kelly Kernan, Adam Bailey, Ake Lernmark, et al.
  (2011) Journal of Bioscience and Bioengineering
  Journal article
- The Environmental Determinants of Diabetes in the Young (TEDDY): genetic criteria and international diabetes risk screening of 421 000 infants.
  William A Hagopian, Henry Erlich, Åke Lernmark, Marian Rewers, Anette G Ziegler, et al.
  (2011) Pediatric Diabetes
  Journal article
- The three ZNT8 autoantibody variants together improve the diagnostic sensitivity of childhood and adolescent type 1 diabetes.
  Cecilia K Andersson, Karin Larsson, Fariba Vaziri Sani, Kristian Lynch, Annelie Carlsson, et al.
  (2011) Autoimmunity
  Journal article
- Vaccination against type 1 diabetes.
  Helena Elding Larsson, Åke Lernmark
  (2011) Journal of Internal Medicine1989-01-01+01:00
  Journal article
2010
- A distinct metabolic profile at birth identifies children developing type 1 diabetes before 20 years of age
  Daria La Torre, Åke Lernmark, Peter Spégel, H. Elding Larsson, Sten Ivarsson, et al.
  (2010) Diabetologia
  Conference paper: abstract
- Altered natural killer (NK) cell frequency and phenotype in latent autoimmune diabetes in adults (LADA) prior to insulin deficiency.
  Christina Silver, K Uvebrant, Cecilia Oderup, Kristian Lynch, R A Harris, et al.
  (2010) Clinical and Experimental Immunology
  Journal article
- Autoimmune type 1 diabetes.
  Ahmed Delli, Helena Larsson, Sten Ivarsson, Åke Lernmark
  (2010)
  Book chapter
- Changes in GAD65Ab-Specific Antiidiotypic Antibody Levels Correlate with Changes in C-Peptide Levels and Progression to Islet Cell Autoimmunity.
  E Ortqvist, B Brooks-Worrell, Kristian Lynch, J Radtke, L M Bekris, et al.
  (2010) The Journal of clinical endocrinology and metabolism
  Journal article
- Clinical and genetical characterisation of a series of patients with type 1 diabetes induced by interferon therapy
  Ahmed Delli, Fariba Vaziri Sani, Annelie Carlsson, G. Forsander, Sten Ivarsson, et al.
  (2010) Diabetologia
  Conference paper: abstract
- Comparison of Radioimmunoprecipitation With Luciferase Immunoprecipitation for Autoantibodies to GAD65 and IA-2 beta
  Peter D. Burbelo, Hiroki Hirai, Alexandra T. Issa, Albert Kingman, Åke Lernmark, et al.
  (2010) Diabetes Care
  Journal article
- Context and disease when disease risk is low: the case of type 1 diabetes in Sweden
  Kristian Lynch, S. V. Subramanian, Henrik Ohlsson, Basile Chaix, Åke Lernmark, et al.
  (2010) Journal of Epidemiology and Community Health
  Journal article
- Differential effects of leptin receptor mutation on male and female BBDR.Gimap5-/Gimap5- spontaneously diabetic rats
  Daniel H. Moralejo, Carl T. Hansen, Piper Treuting, Martin J Hessner, Jessica M. Fuller, et al.
  (2010) Physiological Genomics
  Journal article
- First trimester cytokine levels in mothers to children diagnosed with islet autoimmunity or type 1 diabetes before eight years of age
  Sabina Lindehammer, Malin Fex, Karel Marsal, Åke Lernmark
  (2010) Diabetologia
  Conference paper: abstract
- Future drug treatment of Type 1 diabetes
  Helena Larsson, Ahmed Delli, Sten Ivarsson, Åke Lernmark
  (2010)
  Book chapter
- Identification of a serum-induced transcriptional signature associated with type 1 diabetes in the BioBreeding rat
  Mary L. Kaldunski, Shuang Jia, Rhonda Geoffrey, Joel Basken, Simon Prosser, et al.
  (2010) Diabetes
  Journal article
- Immunologic markers at the clinical onset of type 1 diabetes mellitus and the risk of retinopathy 15 years later
  R. A. Jensen, Elisabet Agardh, Åke Lernmark, N. L. Smith, D. S. Siscovick, et al.
  (2010) Diabetologia
  Conference paper: abstract
- Immunology of beta-Cell Destruction.
  Daria La Torre, Åke Lernmark
  (2010) Advances in Experimental Medicine and Biology
  Journal article
- Novel triples mix radio binding assay for the ZnT8 (ZnT8RWQ) autoantibody variants in children with newly diagnosed diabetes
  Fariba Vaziri Sani, Ahmed Delli, Helena Larsson, B Lindblad, Annelie Carlsson, et al.
  (2010) Diabetologia
  Conference paper: abstract
- Prolonged survival and improved glycemia in BioBreeding diabetic rats after early sustained exposure to glucagon-like peptide
  Ofer Yanay, Daniel H. Moralejo, Kelly Kernan, Margaret Brzezinski, Jessica M. Fuller, et al.
  (2010) Journal of Gene Medicine
  Journal article
- Stimulation of 5-HT1a receptor decreased insulin secretion in islets of Langerhans from mice and humans
  Hedvig Bennet, Cecilia Nagorny, Nils Wierup, Marloes Dekker Nitert, Åke Lernmark, et al.
  (2010) Diabetologia
  Conference paper: abstract
- The association between the PTPN22 1858C > T variant and type 1 diabetes depends on HLA risk and GAD65 autoantibodies
  M. Maziarz, M. Janer, J. C. Roach, W. Hagopian, J. P. Palmer, et al.
  (2010) Genes and Immunity
  Journal article
- Type 1 (Insulin-Dependent) Diabetes Mellitus: Etiology, Pathogenesis, Prediction and Prevention.
  Ahmed Delli, Åke Lernmark
  (2010)
  Book chapter
- Type 1 diabetes patients born to immigrants to Sweden increase their native diabetes risk and differ from Swedish patients in HLA types and islet autoantibodies.
  Ahmed Delli, Bengt Lindblad, Annelie Carlsson, Gun Forsander, Sten Ivarsson, et al.
  (2010) Pediatric Diabetes
  Journal article
- ZnT8 autoantibody titers in type 1 diabetes patients decline rapidly after clinical onset.
  Fariba Vaziri Sani, Shilpa Oak, Jared Radtke, Åke Lernmark, Kristian Lynch, et al.
  (2010) Autoimmunity
  Journal article
2009
- Analysis of the rat Iddm14 diabetes susceptibility locus in multiple rat strains: identification of a susceptibility haplotype in the Tcrb-V locus
  John P. Mordes, Laura Cort, Elaine Norowski, Jean Leif, Jessica Fuller, et al.
  (2009) Mammalian Genome
  Journal article
- Comparison of three assays for the detection of GAD65Ab-specific anti-idiotypic antibodies
  Shilpa Oak, Jared Radtke, Mona Landin-Olsson, Carina Törn, Åke Lernmark, et al.
  (2009) Journal of Immunological Methods
  Journal article
- GAD65 vaccination: 5 years of follow-up in a randomised dose-escalating study in adult-onset autoimmune diabetes.
  Carl-David Agardh, Kristian Lynch, M Palmér, Katarina Link, Åke Lernmark
  (2009) Diabetologia
  Journal article
- Genetic Dissection Reveals Diabetes Loci Proximal to the Gimap5 Lymphopenia Gene.
  Jessica Fuller, Marika Bogdani, Terry D Tupling, Richard A Jensen, Ranae Pefley, et al.
  (2009) Physiological Genomics
  Journal article
- Low agreement between radio binding assays in analyzing glutamic acid decarboxylase (GAD65Ab) autoantibodies in patients classified with type 2 diabetes
  Bledar Daka, Maria K. Svensson, Åke Lernmark, Lucia Mincheva-Nilsson, Goran Hallmans, et al.
  (2009) Autoimmunity
  Journal article
- Sequence Variation and Expression of the Gimap Gene Family in the BB Rat
  Elizabeth A. Rutledge, Jessica Fuller, Brian Van Yserloo, Daniel H. Moralejo, Ruth A. Ettinger, et al.
  (2009) Experimental Diabetes Research
  Journal article
- Strong association between SLC30A8 gene variant and ZnT8 autoantibody specificity during disease progression in two independent cohorts of children with newly diagnosed type 1 diabetes
  L. B. Nielsen, Fariba Vaziri Sani, M-L. M. Andersen, S. Porksen, J. Svensson, et al.
  (2009) Diabetologia
  Conference paper: abstract
- Temporal Variation of Ljungan Virus Antibody Levels in Relation to Islet Autoantibodies and Possible Correlation to Childhood Type 1 Diabetes
  Anna-Lena Nilsson, Eliza Lagerquist, Kristian Lynch, Åke Lernmark, Rolandsson Olov
  (2009) Open Pediatric Medicine Journal
  Journal article
- The non-inherited maternal HLA haplotype affects the risk for type 1 diabetes
  Kristina Åkesson, Annelie Carlsson, S. -A. Ivarsson, C. Johansson, B. -M. Weidby, et al.
  (2009) International Journal of Immunogenetics
  Journal article
- The type 1 diabetes protective HLA DQB1*0602 allele is less frequent in gestational diabetes mellitus.
  Anastasia Papadopoulou, Kristian Lynch, Nael Shaat, Anita Nilsson, Barbro Lernmark, et al.
  (2009) Diabetologia
  Journal article
2008
- A comparison of serum and EDTA plasma in the measurement of glutamic acid decarboxylase autoantibodies (GADA) and autoantibodies to islet antigen-2 (IA-2A) using the RSR radioimmunoassay (RIA) and enzyme linked immunosorbent assay (ELISA) kits.
  Kobra Rahmati, Åke Lernmark, Charlotte Becker, Anna Foltyn Zadura, Karin Larsson, et al.
  (2008) Clinical Laboratory
  Journal article
- Annual screening detects celiac disease in children with type 1 diabetes
  Karin Larsson, Annelie Carlsson, Elisabeth Cederwall, Bjorn Jonsson, Jan Neiderud, et al.
  (2008) Pediatric Diabetes
  Journal article
- Antigen presentation of detergent-free glutamate decarboxylase (GAD65) is affected by human serum albumin as carrier protein
  Jordan T Steed, Lisa K Gilliam, Robert A Harris, Åke Lernmark, Christiane S Hampe
  (2008) Journal of Immunological Methods
  Journal article
- Children developing type 1 diabetes before 6 years of age have increased linear growth independent of HLA genotypes.
  Helena Larsson, Gertie Hansson, Annelie Carlsson, E Cederwall, B Jonsson, et al.
  (2008) Diabetologia
  Journal article
- Comment on : Edghill et al. (2008) insulin mutation screening in 1,044 patients with diabetes: mutations in the ins gene are a common cause of neonatal diabetes but a rare cause of diabetes diagnosed in childhood or adulthood: diabetes 57:1034-1042, 2008
  Sten A. Ivarsson, Åke Lernmark
  (2008) Diabetes
  Journal article (letter)
- Cord blood islet autoantibodies and seasonal association with the type 1 diabetes high-risk genotype.
  Kristian Lynch, Barbro Lernmark, Juan Merlo, Maria Roberta Cilio, S-A Ivarsson, et al.
  (2008) Journal of Perinatology
  Journal article
- Cutaneous Microvascular Dysfunction Is Associated With Human Leukocyte Antigen-DQ in Youths With Type 1 Diabetes.
  Michal Odermarsky, Åke Lernmark, Lennart Truedsson, Petru Liuba
  (2008) Pediatric Research
  Journal article
- Cutaneous microvascular dysfunction is associated with diabetes-risk HLA in youths with type 1 diabetes
  Michal Odermarsky, Åke Lernmark, Petru Liuba
  (2008) Journal of the American College of Cardiology
  Conference paper: abstract
- Decreasing humoral activity in siblings of type 1 diabetes children over a ten year period with increasing incidence of the disease
  J. Svensson, Anita Ramelius, S. Eising, H. Mortensen, Åke Lernmark, et al.
  (2008) Diabetologia
  Conference paper: abstract
- GAD65 Autoimmunity-Clinical Studies
  Raivo Uibo, Åke Lernmark
  (2008) Advances in Immunology
  Journal article review
- GAD65 vaccination significantly reduces insulin dependence at five years follow-up in a dose escalating study in adult-onset autoimmune diabetes patients
  Carl-David Agardh, Kristian Lynch, M. Palmer, Katarina Link, Åke Lernmark
  (2008) Diabetologia
  Conference paper: abstract
- HLA class II alleles specify phenotypes of ketosis-prone diabetes
  Ramaswami Nalini, Lakshmi K Gaur, Mario Maldonado, Christiane S Hampe, Lucille Rodriguez, et al.
  (2008) Diabetes Care
  Journal article
- Impaired survival of peripheral T cells, disrupted NK/NKT cell development, and liver failure in mice lacking Gimap5
  Ryan D. Schulteis, Haiyan Chu, Xuezhi Dai, Yuhong Chen, Brandon Edwards, et al.
  (2008) Blood
  Journal article
- Increased Lipid Oxidation Heralds Diabetes Onset in DR.lyp/lyp Rats.
  Lina Åkesson, R Gelling, R Jensen, K Ogimoto, J Fuller, et al.
  (2008) Experimental and Clinical Endocrinology & Diabetes1995-01-01+01:00
  Journal article
- Maternal enterovirus infection during pregnancy as a risk factor in offspring diagnosed with type 1 diabetes between 15 and 30 years of age.
  Maria Elfving, Johan Svensson, Sami Oikarinen, Björn Jonsson, Per Olofsson, et al.
  (2008) Experimental Diabetes Research
  Journal article
- Number of islet autoantibodies present in newly diagnosed type 1 diabetes children born to non-diabetic mothers is affected by islet autoantibodies present at birth.
  Maria Elfving, Bengt Lindberg, Kristian Lynch, Majvi Månsson, Göran Sundkvist, et al.
  (2008) Pediatric Diabetes
  Journal article
- Risk Conferred by HLA-DR and DQ for Type 1 Diabetes in 0-35-Year Age Group in Sweden
  Carani B. Sanjeevi, Saikiran K Sedimbi, Mona Landin-Olsson, Ingrid Kockum, Åke Lernmark
  (2008)
  Conference paper
- Selective screening of secretory vesicle-associated proteins for autoantigens in type 1 diabetes: VAMP2 and NPY are new minor autoantigens
  Hiroki Hirai, Junnosuke Miura, Yafang Hu, Helena Larsson, Karin Larsson, et al.
  (2008) Clinical Immunology1999-01-01+01:00
  Journal article
- Temporal trends of HLA genotype frequencies of type 1 diabetes patients in Sweden from 1986 to 2005 suggest altered risk.
  Sabina Lindehammer, Karin Larsson, Eva Örtqvist, Annelie Carlsson, E Cederwall, et al.
  (2008) Acta Diabetologica
  Journal article
- Treatment of diabetic rats with encapsulated islets
  Ian R. Sweet, Ofer Yanay, Lanaya Waldron, Merle Gilbert, Jessica M. Fuller, et al.
  (2008) Journal of Cellular and Molecular Medicine
  Journal article
2007
- A variant in the transcription factor 7-like 2 (TCF7L2) gene is associated with an increased risk of gestational diabetes mellitus.
  Nael Shaat, Åke Lernmark, Ella Ekholm, Sten Ivarsson, Hemang Parikh, et al.
  (2007) Diabetologia
  Journal article
- Antibodies to GAD65 and peripheral nerve function in the DCCT.
  RD Hoeldtke, CS Hampe, LM Bekris, G Hobbs, KD Bryner, et al.
  (2007) J Neuroimmunol.
  Journal article
- Atherogenic vascular and lipid phenotypes in young patients with Type 1 diabetes are associated with diabetes high-risk HLA genotype
  Michal Odermarsky, Anita Ramelius, Åke Lernmark, Sture Sjöblad, Petru Liuba
  (2007) American Journal of Physiology: Heart and Circulatory Physiology
  Journal article
- Decreased core temperature and Increased beta(3)-Adrenergic sensitivity in diabetes-prone BB rats
  Lina Åkesson, Tyson Hawkins, Richard Jensen, Jessica M. Fuller, Norman E. Breslow, et al.
  (2007) Diabetes Technology & Therapeutics
  Journal article
- Epitope Analysis of GAD65 Binding in both Cord Blood and at the Time of Clinical Diagnosis of Childhood Type 1 Diabetes.
  Maria Elfving, Bengt Lindberg, Kristian Lynch, Sten Ivarsson, Åke Lernmark, et al.
  (2007) Hormone and Metabolic Research
  Journal article
- GAD65 autoantibody epitopes in adult patients with latent autoimmune diabetes following GAD65 vaccination
  L. M. Bekris, R. A. Jensen, E. Lagerquist, T. R. Hall, Carl-David Agardh, et al.
  (2007) Diabetic Medicine
  Journal article
- Glutamate cysteine ligase catalytic subunit promoter polymorphisms and associations with type 1 diabetes age-at-onset and GAD65 autoantibody levels.
  LM Bekris, C Shephard, M Janer, J Graham, B McNeney, et al.
  (2007) Exp Clin Endocrinol Diabetes
  Journal article
- IA-2 autoantibodies in incident type I diabetes patients are associated with a polyadenylation signal polymorphism in GIMAP5.
  JH Shin, M Janer, B McNeney, S Blay, K Deutsch, et al.
  (2007) Genes Immun.
  Journal article
- Islet cell autoantibody levels after the diagnosis of young adult diabetic patients
  R. Jensen, L. Gilliam, Carina Törn, Mona Landin-Olsson, J. Palmer, et al.
  (2007) Diabetic Medicine
  Journal article
- Low-density cells isolated from the rat thymus resemble branched cortical macrophages and have a reduced capability of rescuing double-positive thymocytes from apoptosis in the BB-DP rat.
  V Sommandas, EA Rutledge, B Van Yserloo, J Fuller, Åke Lernmark, et al.
  (2007) J Leukoc Biol.
  Journal article
- Multiple factors affect the loss of measurable C-peptide over 6 years in newly diagnosed 15- to 35-year-old diabetic subjects
  Richard A. Jensen, Lisa K. Gilliam, Carina Törn, Mona Landin-Olsson, F. Anders Karlsson, et al.
  (2007) Journal of Diabetes and its Complications1992-01-01+01:00
  Journal article
- No evidence of association of the PDCD1 gene with Type 1 diabetes
  S. Fawwaz, P. Nikamo, Carina Törn, Mona Landin-Olsson, Åke Lernmark, et al.
  (2007) Diabetic Medicine
  Journal article
- Relationship between increased relative birthweight and infections during pregnancy in children with a high-risk diabetes HLA genotype.
  Helena Larsson, Kristian Lynch, Barbro Lernmark, Gertie Hansson, Åke Lernmark, et al.
  (2007) Diabetologia
  Journal article
- Relative predispositional effects of HLA class II DRB1-DQB1 haplotypes and genotypes on type 1 diabetes: a meta-analysis.
  G Thomson, AM Valdes, JA Noble, I Kockum, MN Grote, et al.
  (2007) Tissue Antigens
  Journal article
- Species and epitope specificity of two 65 kDa glutamate decarboxylase time-resolved fluorometric immunoassays.
  M Rui, CS Hampe, C Wang, Z Ling, FK Gorus, et al.
  (2007) Journal of Immunological Methods
  Journal article
- The BioBreeding rat diabetes model is infected with Ljungan virus
  Bo Niklasson, T Hultman, R Kallies, M Niedrig, R. Nilsson, et al.
  (2007) Diabetologia
  Journal article (letter)
- The environmental determinants of diabetes in the young (TEDDY) study: Study design
  The TEDDY study group, Åke Lernmark, Peter Almgren, Carin Andrén Aronsson, Eva Andersson, et al.
  (2007) Pediatric Diabetes
  Journal article
- The importance of CTLA-4 polymorphism and human leukocyte antigen genotype for the induction of diabetes-associated cytokine response in healthy school children.
  CO Jonson, Åke Lernmark, J Ludvigsson, EA Rutledge, A Hinkkanen, et al.
  (2007) Pediatr Diabetes
  Journal article
- Two insulin gene single nucleotide polymorphisms associated with type 1 diabetes risk in the Finnish and Swedish populations
  Antti-Pekka Laine, Hanna Holmberg, Anita Ramelius, E. Ortqvist, Minna Kiviniemi, et al.
  (2007) Disease Markers
  Journal article
- Type 1 diabetes risk analysis on dried blood spot samples from population-based newborns: design and feasibility of an unselected case-control study
  Stefanie Eising, Jannet Svensson, Kristin Skogstrand, Anita Ramelius, Kristian Lynch, et al.
  (2007) Paediatric and Perinatal Epidemiology
  Journal article
2006
- Accuracy and predictive value of classification schemes for ketosis-prone diabetes
  Ashok Balasubramanyam, Gilberto Garza, Lucille Rodriguez, Christiane S Hampe, Lakshmi K Gaur, et al.
  (2006) Diabetes Care
  Journal article
- Age-dependent loss of tolerance to an immunodominant epitope of glutamic acid decarboxylase in diabetic-prone RIP-B7/DR4 mice.
  John A Gebe, Kellee A Unrath, Ben A Falk, Ito Kouichi, Li Wen, et al.
  (2006) Clinical Immunology1999-01-01+01:00
  Journal article
- Common variants in MODY genes increase the risk of gestational diabetes mellitus.
  Nael Shaat, Ella Ekholm, Åke Lernmark, Sten Ivarsson, Kristian Lynch, et al.
  (2006) Diabetologia
  Journal article
- Cord blood islet autoantibodies are related to stress in the mother during pregnancy.
  Barbro Lernmark, Kristian Lynch, Åke Lernmark, DiPiS Study Group
  (2006) Annals of the New York Academy of Sciences
  Journal article
- Effects of duration of type 2 diabetes mellitus on insulin secretion.
  F Zangeneh, P S Arora, P J Dyck, L Bekris, Åke Lernmark, et al.
  (2006) Endocrine Practice
  Journal article
- Evidence for immunological priming and increased frequency of CD4(+) CD25(+) cord blood T cells in children born to mothers with type 1 diabetes.
  B C Holm, J Svensson, Christina Silver, Jeanette Arvastsson, June Ljungberg, et al.
  (2006) Clinical and Experimental Immunology
  Journal article
- Evidence of a functional role for mast cells in the development of type 1 diabetes mellitus in the biobreeding rat
  Rhonda Geoffrey, Shuang Jia, Anne E. Kwitek, Jeffrey Woodliff, Soumitra Ghosh, et al.
  (2006) Journal of Immunology
  Journal article
- Genetic mapping at 3-kilobase resolution reveals inositol 1,4,5-triphosphate receptor 3 as a risk factor for type 1 diabetes in Sweden.
  J C Roach, K Deutsch, S Li, A F Siegel, L M Bekris, et al.
  (2006) American Journal of Human Genetics
  Journal article
- Increased galanin expression in the celiac ganglion of BB diabetic rats
  Qi Mei, Thomas O Mundinger, Åke Lernmark, Gerald J Taborsky
  (2006) Neuropeptides
  Journal article
- Introgression of F344 rat genomic DNA on BB rat chromosome 4 generates diabetes-resistant lymphopenic BB rats.
  Jessica Fuller, A E Kwitek, T J Hawkins, D H Moralejo, W Lu, et al.
  (2006) Diabetes
  Journal article
- MHC class I chain-related gene-A is associated with IA2 and IAA but not GAD in Swedish type 1 diabetes mellitus
  Manu Gupta, Jinko Graham, Brian McNeeny, Marian Zarghami, Mona Landin-Olsson, et al.
  (2006) Annals of the New York Academy of Sciences
  Journal article
- Prenatal viral exposure followed by adult stress produces glucose intolerance in a mouse model.
  B Niklasson, A Samsioe, M Blixt, S Sandler, A Sjöholm, et al.
  (2006) Diabetologia
  Journal article
- Reduction of tissue transglutaminase autoantibody levels by gluten-free diet is associated with changes in subsets of peripheral blood lymphocytes in children with newly diagnosed coeliac disease.
  Daniel Agardh, Kristian Lynch, Charlotte Brundin, S-A Ivarsson, Åke Lernmark, et al.
  (2006) Clinical and Experimental Immunology
  Journal article
- TEDDY- The environmental determinants of diabetes in the young - An observational clinical trial
  William A. Hagopian, Åke Lernmark, Marian J. Rewers, Olli G. Simell, Jin-Xiong She, et al.
  (2006) Annals of the New York Academy of Sciences
  Journal article
- Targeting type 1 diabetes before and at the clinical onset of disease.
  L M Bekris, T J Kavanagh, Åke Lernmark
  (2006) Endocrine, Metabolic & Immune Disorders - Drug Targets
  Journal article
2005
- Association of the E23K polymorphism in the KCNJ11 gene with gestational diabetes mellitus.
  Nael Shaat, M Ekelund, Åke Lernmark, Sten Ivarsson, Peter Almgren, et al.
  (2005) Diabetologia
  Journal article
- Autoantibodies Against Soluble and Immobilized Human Recombinant Tissue Transglutaminase in Children with Celiac Disease.
  Daniel Agardh, Ingrid Dahlbom, Terri Daniels, Ester Lörinc, Sten Ivarsson, et al.
  (2005) Journal of Pediatric Gastroenterology and Nutrition - Jpgn
  Journal article
- Autoantibodies in diabetes.
  C Pihoker, L K Gilliam, C S Hampe, Åke Lernmark
  (2005) Diabetes
  Journal article
- Calcium activation of tissue transglutaminase in radioligand binding and enzyme-linked autoantibody immunoassays in childhood celiac disease.
  Daniel Agardh, Bodil Roth, Åke Lernmark, Pål Stenberg
  (2005) Clinica Chimica Acta
  Journal article
- Clinical evidence for the safety of GAD65 immunomodulation in adult-onset autoimmune diabetes.
  Carl-David Agardh, Corrado M Cilio, ÅsaLinda Lethagen, Kristian Lynch, R David G Leslie, et al.
  (2005) Journal of Diabetes and its Complications1992-01-01+01:00
  Journal article
- D6S265*15 marks a DRB1*15, DQB1*0602 haplotype associated with attenuated protection from type 1 diabetes mellitus.
  A M Valdes, G Thomson, J Graham, M Zarghami, B McNeney, et al.
  (2005) Diabetologia
  Journal article (letter)
- DR.lyp/lyp bone marrow maintains lymphopenia and promotes diabetes in lyp/lyp but not in +/+ recipient DR.lyp BB rats
  T Hawkins, J Fuller, K Olson, S Speros, Åke Lernmark
  (2005) Journal of Autoimmunity
  Journal article
- Defects in differentiation of bone-marrow derived dendritic cells of the BB rat are partly associated with IDDM2 (the lyp gene) and partly associated with other genes in the BB rat background.
  V Sommandas, E A Rutledge, B Van Yserloo, J Fuller, Åke Lernmark, et al.
  (2005) Journal of Autoimmunity
  Journal article
- Epitope analysis of insulin autoantibodies using recombinant Fab
  C J Padoa, N J Crowther, J W Thomas, T R Hall, L M Bekris, et al.
  (2005) Clinical and Experimental Immunology
  Journal article
- Glutathione-s-transferase M1 and T1 polymorphisms and associations with type 1 diabetes age-at-onset.
  L M Bekris, C Shephard, M Peterson, J Hoehna, B Van Yserloo, et al.
  (2005) Autoimmunity
  Journal article
- Increased risk of diabetes among relatives of female insulin-treated patients diagnosed at 15-34 years of age.
  K Åkesson, L Nyström, L Färnkvist, J Ostman, Åke Lernmark, et al.
  (2005) Diabetic Medicine
  Journal article
- Medicinska biobanken - en unik resurs för medicinsk forskning
  T Stigbrand, L Rymo, Åke Lernmark
  (2005) Läkartidningen
  Journal article
- Type 1 diabetes--does suppressing T cells increase insulin?
  Åke Lernmark
  (2005) New England Journal of Medicine
  Journal article (letter)
2004
- A high prevalence of organ-specific autoimmunity in patients with bipolar disorder.
  Roos C Padmos, Lynn Bekris, Esther M Knijff, Henning Tiemeier, Ralph W Kupka, et al.
  (2004) Biological Psychiatry
  Journal article
- Aberrancies in the differentiation and maturation of dendritic cells from bone-marrow precursors are linked to various genes on chromosome 4 and other chromosomes of the BB-DP rat.
  Vinod Sommandas, Elizabeth A. Rutledge, Brian Van Yserloo, Jessica Fuller, Åke Lernmark, et al.
  (2004) Journal of Autoimmunity
  Journal article
- Development of glutamic acid decarboxylase 65 (GAD65) autoantibody assay using biotin-GAD65 fusion protein.
  Dong Luo, Chad N Rogers, Jordan T Steed, Lisa K Gilliam, Christiane S Hampe, et al.
  (2004) Journal of Biotechnology
  Journal article
- Epitope-restricted 65-kilodalton glutamic acid decarboxylase autoantibodies among new-onset Sardinian type 2 diabetes patients define phenotypes of autoimmune diabetes.
  Mario Maioli, Emilyn Alejandro, Giancarlo Tonolo, Lisa K. Gilliam, Lynn Bekris, et al.
  (2004) Journal of Clinical Endocrinology and Metabolism
  Journal article
- Genetic and perinatal factors as risk for childhood type 1 diabetes
  K Larsson, Helena Larsson, E Cederwall, K Kockum, Sture Sjöblad, et al.
  (2004) Diabetes/Metabolism Research Reviews
  Journal article review
- Genotypic and phenotypic differences between Arabian and Scandinavian women with gestational diabetes mellitus.
  Nael Shaat, M. Ekelund, Åke Lernmark, Sten Ivarsson, A. Nilsson, et al.
  (2004) Diabetologia
  Journal article
- HLA-DRB1, -DQA1, and -DQB1 subtypes or ACE gene polymorphisms do not seem to be risk markers for severe retinopathy in younger Type 1 diabetic patients.
  Elisabet Agardh, Lakshmi K Gaur, Åke Lernmark, Carl-David Agardh
  (2004) Journal of Diabetes and its Complications1992-01-01+01:00
  Journal article
- Immune intervention for prevention of type 1 diabetes
  Åke Lernmark
  (2004)
  Conference paper
- Involvement of eotaxin, eosinophils, and pancreatic predisposition in development of type 1 diabetes mellitus in the BioBreeding rat.
  Martin J Hessner, Xujing Wang, Lisa Meyer, Rhonda Geoffrey, Shuang Jia, et al.
  (2004) Journal of Immunology
  Journal article
- Non-invasive imaging of beta cell mass: a quantitative analysis.
  Ian R Sweet, Daniel L Cook, Åke Lernmark, Carla J Greenbaum, Kenneth A Krohn
  (2004) Diabetes Technology & Therapeutics
  Journal article
- Preface.
  A L Notkins, Åke Lernmark, D Leslie
  (2004) Autoimmunity
  Journal article
- Systematic screening of potential beta-cell imaging agents.
  Ian R Sweet, Carla J. Cook, Åke Lernmark, Carla J. Greenbaum, Angela R Wallen, et al.
  (2004) Biochemical and Biophysical Research Communications
  Journal article
- Transgenic rescue demonstrates involvement of the Ian5 gene in T cell development in the rat.
  Mieczyslaw Michalkiewicz, Teresa Michalkiewicz, Ruth A. Ettinger, Elizabeth A. Rutledge, Jessica M. Fuller, et al.
  (2004) Physiological Genomics
  Journal article
- Using radioligand-binding assays to measure tissue transglutaminase autoantibodies in young children.
  Daniel Agardh, Annelie Carlsson, Kristian Lynch, Irene Axelsson, Åke Lernmark, et al.
  (2004) Acta Pædiatrica
  Journal article
2003
- Bead injection ELISA for the determination of antibodies implicated in type 1 diabetes mellitus.
  Andrea D Carroll, Louis Scampavia, Dong Luo, Åke Lernmark, Jaromir Ruzicka
  (2003) Analyst
  Journal article
- Development of type 1 diabetes in wild bank voles associated with islet autoantibodies and the novel ljungan virus.
  Bo Niklasson, Knud E Heller, Bryan Schønecker, Mogens Bildsøe, Terri Daniels, et al.
  (2003) International journal of experimental diabesity research
  Journal article
- Diabetes Type 1 (Insulin-Dependent Diabetes Mellitus).
  Lisa K Gilliam, Åke Lernmark
  (2003)
  Book chapter
- GAD2 on chromosome 10p12 is a candidate gene for human obesity.
  Philippe Boutin, Christian Dina, Francis Vasseur, Séverine Dubois, Laetitia Corset, et al.
  (2003) PLoS Biology
  Journal article
- Genetic dissection of lymphopenia from autoimmunity by introgression of mutated Ian5 gene onto the F344 rat.
  Daniel H Moralejo, Hyunhee A Park, Sara J Speros, Armand J MacMurray, Anne E Kwitek, et al.
  (2003) Journal of Autoimmunity
  Journal article
- High GAD65 autoantibody levels in nondiabetic adults are associated with HLA but not with CTLA-4 or INS VNTR.
  O Rolandsson, E Hägg, M Janer, E Rutledge, L K Gaur, et al.
  (2003) Journal of Internal Medicine1989-01-01+01:00
  Journal article
- Impaired glucagon response to sympathetic nerve stimulation in the BB diabetic rat: effect of early sympathetic islet neuropathy.
  Thomas O Mundinger, Qi Mei, Dianne P Figlewicz, Åke Lernmark, Gerald J Jr Taborsky
  (2003) American Journal of Physiology: Endocrinology and Metabolism
  Journal article
- Islet autoantibodies in cord blood from patients who developed type 1 diabetes mellitus at 15-30 years of age.
  Maria Elfving, Bengt Lindberg, Lennarth Nyström, Göran Sundkvist, Åke Lernmark, et al.
  (2003) Autoimmunity
  Journal article
- Ketosis-prone diabetes: dissection of a heterogeneous syndrome using an immunogenetic and beta-cell functional classification, prospective analysis, and clinical outcomes
  Mario Maldonado, Christiane S Hampe, Lakshmi K Gaur, Susana D'Amico, Dinakar Iyer, et al.
  (2003) Journal of Clinical Endocrinology and Metabolism
  Journal article
- Molecular Biology of β-Cell Destruction
  Åke Lernmark, Choon Hee Chung
  (2003)
  Book chapter
- Molecular engineering of biotin-glutamic acid decarboxylase 65 fusion protein (Biotin-GAD65) for non-radioactive GAD65 antibody assay
  Dong Luo, Chad N Rogers, Christiane S Hampe, Åke Lernmark
  (2003) Journal of Biotechnology
  Journal article
- Standardization of antibody preparations for use in immunogenicity studies: a case study using the World Health Organization International Collaborative Study for Islet Cell Antibodies.
  A Mire-Sluis, R Gaines Das, Åke Lernmark
  (2003) Developments in Biologicals
  Journal article
- Tissue transglutaminase immunoglobulin isotypes in children with untreated and treated celiac disease
  Daniel Agardh, Stefan Borulf, Åke Lernmark, Sten Ivarsson
  (2003) Journal of Pediatric Gastroenterology and Nutrition - Jpgn
  Journal article
- Type 1 diabetes in Swedish bank voles (Clethrionomys glareolus): signs of disease in both colonized and wild cyclic populations at peak density.
  Bo Niklasson, Birger Hörnfeldt, Erik Nyholm, Matthias Niedrig, Oliver Donoso-Mantke, et al.
  (2003) Annals of the New York Academy of Sciences
  Journal article
- Unique epitopes of glutamic acid decarboxylase autoantibodies in slowly progressive type 1 diabetes.
  Tetsuro Kobayashi, Shoichiro Tanaka, Minoru Okubo, Koji Nakanishi, Toshio Murase, et al.
  (2003) Journal of Clinical Endocrinology and Metabolism
  Journal article
2002
- Animal models of endocrine/organ-specific autoimmune diseases: do they really help us to understand human autoimmunity?
  WK Lam-Tse, Åke Lernmark, HA Drexhage
  (2002) Springer Seminars in Immunopathology1978-01-01+01:002006-01-01+01:00
  Journal article
- Controlling the controls: GAD65 autoreactive T cells in type 1 diabetes.
  Åke Lernmark
  (2002) Journal of Clinical Investigation
  Journal article (letter)
- Dynamic perifusion to maintain and assess isolated pancreatic islets.
  I R Sweet, D L Cook, R W Wiseman, C J Greenbaum, Åke Lernmark, et al.
  (2002) Diabetes Technology & Therapeutics
  Journal article
- Early, selective, and marked loss of sympathetic nerves from the islets of BioBreeder diabetic rats.
  Q Mei, TO Mundinger, Åke Lernmark, GJ Jr. Taborsky
  (2002) Diabetes
  Journal article
- GAD65 and IA-2 autoantibodies are common in a subset of siblings of Sardinian Type 2 diabetes families.
  Mario Maioli, G Tonolo, L Bekris, R Cirillo, D Schranz, et al.
  (2002) Diabetes Research and Clinical Practice
  Journal article
- GAD65 antibody epitope patterns of type 1.5 diabetic patients are consistent with slow-onset autoimmune diabetes.
  Christiane S Hampe, Ingrid Kockum, Mona Landin-Olsson, Carina Törn, Eva Ortqvist, et al.
  (2002) Diabetes Care
  Journal article (letter)
- Genetic effects on age-dependent onset and islet cell autoantibody markers in type 1 diabetes.
  J Graham, WA Hagopian, I Kockum, LS Li, CB Sanjeevi, et al.
  (2002) Diabetes
  Journal article
- Induction of donor-specific tolerance to islet allografts in nonhuman primates.
  LK Gaur, E Kennedy, Y Nitta, GT Nepom, KA Nelson, et al.
  (2002) Annals of the New York Academy of Sciences
  Journal article
- Induction of islet allotolerance in nonhuman primates
  Lakshmi K Gaur, Y Nitta, E. Kennedy, Å Lernmark, Keith A. Nelson, et al.
  (2002) Annals of the New York Academy of Sciences
  Journal article
- Lymphopenia in the BB rat model of type 1 diabetes is due to a mutation in a novel immune-associated nucleotide (Ian)-related gene.
  Armand J. MacMurray, Daniel H. Moralejo, Anne E. Kwitek, Elizabeth A. Rutledge, Brian Van Yserloo, et al.
  (2002) Genome Research
  Journal article
- Macrophages from high-risk HLA-DQB1*0201/*0302 type 1 diabetes mellitus patients are hypersensitive to lipopolysaccharide stimulation.
  A Plesner, C J Greenbaum, L K Gaur, R K Ernst, Åke Lernmark
  (2002) Scandinavian Journal of Immunology
  Journal article
- Multiple sclerosis and type 1 diabetes: an unlikely alliance.
  Åke Lernmark
  (2002) The Lancet
  Journal article
- Protein-free diets do not protect high-incidence diabetes-prone BioBreeding rats from diabetes.
  W Simonson, S Ramanathan, S Bieg, P Poussier, Åke Lernmark
  (2002) Metabolism: Clinical and Experimental
  Journal article
- Serum IgG to heat shock proteins and Porphyromonas gingivalis antigens in diabetic patients with periodontitis.
  TJ Sims, Åke Lernmark, LA Mancl, RE Schifferle, RC Page, et al.
  (2002) Journal of Clinical Periodontology
  Journal article
- Stable GAD65 autoantibody epitope patterns in type 1 diabetes children five years after onset.
  CS Hampe, LP Hammerle, L Bekris, E Ortqvist, B Persson, et al.
  (2002) Journal of Autoimmunity
  Journal article
- Streptozotocin induced diabetes in minipig: a case report of a possible model for type 1 diabetes?
  O Rolandsson, M F Haney, E Hagg, B Biber, Åke Lernmark
  (2002) Autoimmunity
  Journal article
- Studies on the association between 2'5'-oligoadenylate synthetase and type 1 diabetes.
  M Zarghami, V Bonnevie-Nielsen, R Tobias, M Engel, J Graham, et al.
  (2002)
  Conference paper
- The antibody response to bacteriophage is linked to the lymphopenia gene in congenic BioBreeding rats.
  L Clark, C Greenbaum, J Jiang, Åke Lernmark, H Ochs
  (2002) Pathogens and Disease
  Journal article
- The combination of several polymorphic amino acid residues in the DQ alpha and DQ beta chains forms a domain structure pattern and is associated with insulin-dependent diabetes mellitus
  CB Sanjeevi, Mona Landin-Olsson, I Kockum, G Dahlquist, Åke Lernmark
  (2002) Annals of the New York Academy of Sciences
  Journal article
- Type 1 diabetes as a model for prediction and diagnosis.
  Åke Lernmark
  (2002) Autoimmunity
  Journal article
- Type 1 diabetes-related autoantibodies are rare in Alaska native populations.
  J Mohatt, LK Gilliam, L Bekris, S Ebbesson, Åke Lernmark
  (2002) Circumpolar Health Supplements
  Journal article
2001
- A novel monoclonal antibody specific for the N-terminal end of GAD65
  Christiane S Hampe, Per Lundgren, Terri L Daniels, Lisa P Hammerle, Santica M. Marcovina, et al.
  (2001) Journal of Neuroimmunology
  Journal article
- Activated human epitope-specific T cells identified by class II tetramers reside within a CD4high, proliferating subset
  Erik J. Novak, Susan A. Masewicz, Andrew W. Liu, Åke Lernmark, William W. Kwok, et al.
  (2001) International Immunology
  Journal article
- Autoimmune diseases : Are markers ready for prediction?
  Åke Lernmark
  (2001) Journal of Clinical Investigation
  Journal article review
- Autoimmune type 1 diabetes : Resolved and unresolved issues
  Abner Louis Notkins, Åke Lernmark
  (2001) Journal of Clinical Investigation
  Journal article review
- Combinations of beta cell specific autoantibodies at diagnosis of diabetes in young adults reflects different courses of beta cell damage
  Carina Törn, Mona Landin-Olsson, Åke Lernmark, Bengt Scherstén, J. Ostman, et al.
  (2001) Autoimmunity
  Journal article
- Gene and Cell-Replacement Therapy in the Treatment of Type 1 Diabetes : How High Must the Standards Be Set?
  Philippe A Halban, Steven E Kahn, Åke Lernmark, Christopher J. Rhodes
  (2001) Diabetes
  Journal article review
- Glucose-regulated insulin expression in diabetic rats
  S. C. Barry, N. Ramesh, D. V. Lejnieks, William T Simonson, L. Kemper, et al.
  (2001) Human Gene Therapy
  Journal article
- Low serum conditions for in vitro generation of human macrophages with macrophage colony stimulating factor
  Annette Plesner, Carla J Greenbaum, Åke Lernmark
  (2001) Journal of Immunological Methods
  Journal article
- Low-dose streptozotocin induces sustained hyperglycemia in Macaca nemestrina
  L K Gaur, Gerald T Nepom, Å Lernmark
  (2001) Autoimmunity
  Journal article
- Molecular manipulation of autoantibody testing in type 1 diabetes : Two for one
  David B. Sacks, A. Lernmark
  (2001) Clinical Chemistry
  Journal article (comment)
- Prediction of diabetes with body mass index, oral glucose tolerance test and islet cell autoantibodies in a regional population
  O Rolandsson, E. Hägg, M. Nilsson, G Hallmans, Lucia Mincheva-Nilsson, et al.
  (2001) Journal of Internal Medicine1989-01-01+01:00
  Journal article
- Prediction of silent celiac disease at diagnosis of childhood type 1 diabetes by tissue transglutaminase autoantibodies and HLA
  Daniel Agardh, Anita Ramelius, Tiinamaija Toumi, Bengt Lindberg, Anneli K Carlsson, et al.
  (2001) Pediatric Diabetes
  Journal article
- Preservation of enzyme activity and antigenicity after mutagenesis of the membrane anchoring domain of GAD65
  Annette Plesner, Christiane S Hampe, Terri L Daniels, Lisa P Hammerle, Åke Lernmark
  (2001) Autoimmunity
  Journal article
- Site-directed mutagenesis of K396R of the 65 kDa glutamic acid decarboxylase active site obliterates enzyme activity but not antibody binding
  Christiane S Hampe, Lisa P Hammerle, Alberto Falorni, John D. Robertson, Åke Lernmark
  (2001) FEBS Letters
  Journal article
- Treatment outcome for IDDM patients in relation to glutamic acid decarboxylase autoantibodies and serum IgG to periodontal pathogens
  Tom J. Sims, Åke Lernmark, Todd Smith, Roy C. Page, G. Rutger Persson
  (2001) Journal of Clinical Periodontology
  Journal article
2000
- Alternative splicing of GAD67 results in the synthesis of a third form of glutamic-acid decarboxylase in human islets and other non-neural tissues
  Steven D. Chessler, Åke Lernmark
  (2000) Journal of Biological Chemistry
  Journal article
- Antibodies to glutamic acid decarboxylase and peripheral nerve function in type 1 diabetes
  Robert D. Hoeldtke, Kimberly D. Bryner, Gerald R. Hobbs, Gabriella G. Horvath, Jack E. Riggs, et al.
  (2000) Journal of Clinical Endocrinology and Metabolism
  Journal article
- Evaluation of a novel radioimmunoassay using ¹²⁵I-labelled human recombinant GAD65 for the determination of glutamic acid decarboxylase (GAD65) autoantibodies
  Santica M. Marcovina, M. Landin-Olsson, A. Essen-Möller, J. P. Palmer, Å Lernmark
  (2000) International Journal of Clinical and Laboratory Research
  Journal article
- GAD65-specific autoantibodies enhance the presentation of an immunodominant T-cell epitope from GAD65
  Charlotta af Hällström-Reijonen, Terri L Daniels, A. Lernmark, Gerald T Nepom
  (2000) Diabetes
  Journal article
- Glutamic acid decarboxylase antibodies (GADA) is the most important factor for prediction of insulin therapy within 3 years in young adult diabetic patients not classified as Type 1 diabetes on clinical grounds
  Carina Törn, Mona Landin-Olsson, Jan Östman, Bengt Scherstén, Hans Arnqvist, et al.
  (2000) Diabetes/Metabolism Research and Reviews
  Journal article
- Ketoacidosis in young adults is not related to the islet antibodies at the diagnosis of Type 1 diabetes mellitus - A nationwide study
  Jan Östman, M. Landin-Olsson, C. Törn, J. Palmer, A. Lernmark, et al.
  (2000) Diabetic Medicine
  Journal article
- Newly diagnosed latent autoimmune diabetes in adults (LADA) is associated with low level glutamate decarboxylase (GAD65) and IA-2 autoantibodies
  D. B. Schranz, L Bekris, M. Landin-Olsson, C. Törn, A. Niläng, et al.
  (2000) Hormone and Metabolic Research
  Journal article
- Prognostic factors for the course of β cell function in autoimmune diabetes
  C. Törn, M. Landin-Olsson, Å Lernmark, J. P. Palmer, H. J. Arnqvist, et al.
  (2000) Journal of Clinical Endocrinology and Metabolism
  Journal article
- Rapid-onset type 1 diabetes with pancreatic exocrine dysfunction
  A. Lernmark
  (2000) New England Journal of Medicine
  Journal article (comment)
- Recognition of glutamic acid decarboxylase (GAD) by autoantibodies from different GAD antibody-positive phenotypes
  Christiane S Hampe, Lisa P Hammerle, Lynn Bekris, Eva Örtqvist, Ingrid Kockum, et al.
  (2000) Journal of Clinical Endocrinology and Metabolism
  Journal article
- Rel B is an early marker of autoimmune islet inflammation in the BioBreeding (BB) rat
  Sabine Bieg, William T Simonson, Kristian Ellefsen, Åke Lernmark
  (2000) Pancreas
  Journal article
- Stability of disease-associated antibody titers in pregnant women with type 1 diabetes with or without residual β-cell function [2]
  Eva Nord, Lena Edwall, Christiane S Hampe, Lynn Bekris, Bengt E. Persson, et al.
  (2000) Diabetes Care
  Journal article (letter)
- The World Health Organization international collaborative study for islet cell antibodies
  A. R. Mire-Sluis, R Gaines Das, Å. Lernmark
  (2000) Diabetologia
  Journal article
- The length of the CTLA-4 microsatellite (AT)(N)-repeat affects the risk for type 1 diabetes
  Michael R. Lowe, J Graham, G. Sund, I Kockum, M. Landin-Olsson, et al.
  (2000) Autoimmunity
  Journal article
1999
- Prevalence of β-cell and Thyroid Autoantibody Positivity in Schoolchildren during Three-Year Follow-up
  Bengt Lindberg, Annelie Carlsson, Ulla-Britt Ericsson, Ingrid Kockum, Åke Lernmark, et al.
  (1999) Autoimmunity
  Journal article
1998
- Inverse relationship between GAD65 antibody levels and severe retinopathy in younger type 1 diabetic patients
  Daniel Agardh, Elisabet Agardh, Mona Landin-Olsson, Lakshmi K Gaur, Carl-David Agardh, et al.
  (1998) Diabetes Research and Clinical Practice
  Journal article
1997
- Glutamate decarboxylase antibodies in non-diabetic pregnancy precedes insulin-dependent diabetes in the mother but not necessarily in the offspring
  Sten-A. Ivarsson, Malin Ackefors, Göran Ekberg, Alberto Falorni, Ingrid Kockum, et al.
  (1997) Autoimmunity
  Journal article
1996
- HLA-DQB1*0201/0302 is associated with severe retinopathy in patients with IDDM
  Daniel Agardh, L K Gaur, Elisabet Agardh, Mona Landin-Olsson, Carl-David Agardh, et al.
  (1996) Diabetologia
  Journal article

Publications

Retrieved from Lund University's publications database

Book chapter
- Type 1 Diabetes
  Åke Lernmark, Shehab Alshiekh
  (2016) , 5 p.159-167
- Immunology of β-Cell Destruction
  Åke Lernmark, DARIA LA TORRE, MARKUS LUNDGREN, Helena Larsson
  (2015) , p.1047-1080
- Type 1 (Insulin-Dependent) Diabetes Mellitus
  Ahmed Delli, Åke Lernmark
  (2014) , p.671-691
- Autoimmune (type 1) diabetes
  Ahmed Delli, Åke Lernmark
  (2013) , p.575-585
- Viruses, diabetes, and autoimmunity : Studies of subjects at genetic risk for type 1 diabetes
  Sabina Resic Lindehammer, Åke Lernmark
  (2013) , 9781461440512 p.187-194
- Type 1 (Insulin-Dependent) Diabetes Mellitus: Etiology, Pathogenesis, Prediction and Prevention.
  Ahmed Delli, Åke Lernmark
  (2010) , Volume 1 p.744-764
- Autoimmune type 1 diabetes.
  Ahmed Delli, Helena Larsson, Sten Ivarsson, Åke Lernmark
  (2010) , p.141-152
- Future drug treatment of Type 1 diabetes
  Helena Larsson, Ahmed Delli, Sten Ivarsson, Åke Lernmark
  (2010) , p.1001-1016
- Molecular Biology of β-Cell Destruction
  Åke Lernmark, Choon Hee Chung
  (2003) , p.71-71
- Diabetes Type 1 (Insulin-Dependent Diabetes Mellitus).
  Lisa K Gilliam, Åke Lernmark
  (2003) , 1-3 p.398-406
Conference paper
- Risk Conferred by HLA-DR and DQ for Type 1 Diabetes in 0-35-Year Age Group in Sweden
  Carani B. Sanjeevi, Saikiran K Sedimbi, Mona Landin-Olsson, Ingrid Kockum, Åke Lernmark
  (2008) , 1150 p.106-111
- Immune intervention for prevention of type 1 diabetes
  Åke Lernmark
  (2004)
- Studies on the association between 2'5'-oligoadenylate synthetase and type 1 diabetes.
  M Zarghami, V Bonnevie-Nielsen, R Tobias, M Engel, J Graham, et al.
  (2002)
Conference paper: abstract
- Immunologic markers at the clinical onset of type 1 diabetes mellitus and the risk of retinopathy 15 years later
  R. A. Jensen, Elisabet Agardh, Åke Lernmark, N. L. Smith, D. S. Siscovick, et al.
  (2010) Diabetologia, 53 p.155-155
- Clinical and genetical characterisation of a series of patients with type 1 diabetes induced by interferon therapy
  Ahmed Delli, Fariba Vaziri Sani, Annelie Carlsson, G. Forsander, Sten Ivarsson, et al.
  (2010) Diabetologia, 53 p.273-273
- First trimester cytokine levels in mothers to children diagnosed with islet autoimmunity or type 1 diabetes before eight years of age
  Sabina Lindehammer, Malin Fex, Karel Marsal, Åke Lernmark
  (2010) Diabetologia, 53 p.343-343
- A distinct metabolic profile at birth identifies children developing type 1 diabetes before 20 years of age
  Daria La Torre, Åke Lernmark, Peter Spégel, H. Elding Larsson, Sten Ivarsson, et al.
  (2010) Diabetologia, 53 p.261-261
- Novel triples mix radio binding assay for the ZnT8 (ZnT8RWQ) autoantibody variants in children with newly diagnosed diabetes
  Fariba Vaziri Sani, Ahmed Delli, Helena Larsson, B Lindblad, Annelie Carlsson, et al.
  (2010) Diabetologia, 53 p.264-264
- Stimulation of 5-HT1a receptor decreased insulin secretion in islets of Langerhans from mice and humans
  Hedvig Bennet, Cecilia Nagorny, Nils Wierup, Marloes Dekker Nitert, Åke Lernmark, et al.
  (2010) Diabetologia, 53 p.547-547
- Strong association between SLC30A8 gene variant and ZnT8 autoantibody specificity during disease progression in two independent cohorts of children with newly diagnosed type 1 diabetes
  L. B. Nielsen, Fariba Vaziri Sani, M-L. M. Andersen, S. Porksen, J. Svensson, et al.
  (2009) Diabetologia, 52 p.29-29
- GAD65 vaccination significantly reduces insulin dependence at five years follow-up in a dose escalating study in adult-onset autoimmune diabetes patients
  Carl-David Agardh, Kristian Lynch, M. Palmer, Katarina Link, Åke Lernmark
  (2008) Diabetologia, 51 p.230-230
- Cutaneous microvascular dysfunction is associated with diabetes-risk HLA in youths with type 1 diabetes
  Michal Odermarsky, Åke Lernmark, Petru Liuba
  (2008) Journal of the American College of Cardiology, 51 p.345-345
- Decreasing humoral activity in siblings of type 1 diabetes children over a ten year period with increasing incidence of the disease
  J. Svensson, Anita Ramelius, S. Eising, H. Mortensen, Åke Lernmark, et al.
  (2008) Diabetologia, 51 p.232-233
Journal article
- Rationale for enteroviral vaccination and antiviral therapies in human type 1 diabetes
  Jessica L. Dunne, Sarah J. Richardson, Mark A. Atkinson, Maria E. Craig, Knut Dahl-Jørgensen, et al.
  (2019) Diabetologia
- Time-resolved autoantibody profiling facilitates stratification of preclinical type 1 diabetes in children
  , David Endesfelder, Wolfgang zu Castell, Ezio Bonifacio, Marian Rewers, et al.
  (2019) Diabetes, 68 p.119-130
- Tissue transglutaminase autoantibodies in children with newly diagnosed type 1 diabetes are related to human leukocyte antigen but not to islet autoantibodies : A Swedish nationwide prospective population-based cohort study
  Mara Cerqueiro Bybrant, Lena Grahnquist, Eva Örtqvist, Cecilia Andersson, Gun Forsander, et al.
  (2018) Autoimmunity, 51 p.221-227
- Maternal dietary supplement use and development of islet autoimmunity in the offspring : TEDDY study
  , Katherine Silvis, Carin A. Aronsson, Xiang Liu, Ulla Uusitalo, et al.
  (2018) Pediatric Diabetes
- Progression from islet autoimmunity to clinical type 1 diabetes is influenced by genetic factors : Results from the prospective TEDDY study
  , Andreas Beyerlein, Ezio Bonifacio, Kendra Vehik, Markus Hippich, et al.
  (2018) Journal of Medical Genetics
- First trimester enterovirus IgM and beta cell autoantibodies in mothers to children affected by type 1 diabetes autoimmunity before 7 years of age
  Alexander Lind, Kristian F. Lynch, Markus Lundgren, Åke Lernmark, Peter Almgren, et al.
  (2018) Journal of Reproductive Immunology, 127 p.1-6
- Novel subgroups of adult-onset diabetes and their association with outcomes : A data-driven cluster analysis of six variables
  Emma Ahlqvist, Petter Storm, Annemari Käräjämäki, Mats Martinell, Mozhgan Dorkhan, et al.
  (2018) The Lancet Diabetes and Endocrinology, 6 p.361-369
- Genetic scores to stratify risk of developing multiple islet autoantibodies and type 1 diabetes : A prospective study in children
  Ezio Bonifacio, Andreas Beyerlein, Markus Hippich, Christiane Winkler, Kendra Vehik, et al.
  (2018) PLoS Medicine, 15
- Early infant diet and islet autoimmunity in the TEDDY study
  Ulla Uusitalo, Hye Seung Lee, Carin Andrén Aronsson, Kendra Vehik, Jimin Yang, et al.
  (2018) Diabetes Care, 41 p.522-530
- HLA, infections and inflammation in early stages of atherosclerosis in children with type 1 diabetes
  Michal Odermarsky, Erkki Pesonen, Timo Sorsa, Åke Lernmark, Pirkko Pussinen, et al.
  (2018) Acta Diabetologica, 55 p.41-47
- Reduction in White Blood Cell, Neutrophil, and Red Blood Cell Counts Related to Sex, HLA, and Islet Autoantibodies in Swedish TEDDY Children at Increased Risk for Type 1 Diabetes
  , Falastin Salami, Hye Seung Lee, Eva Freyhult, Helena Elding Larsson, et al.
  (2018) Diabetes, 67 p.2329-2336
- 10 år med BDD-studien har gett bättre diabetesdiagnos hos barn : Studiens analysbatteri är nu klinisk rutin och kunskapen om olika diabetessjukdomar har ökat
  Annelie Carlsson, Gun Forsander, Sten Ivarsson, Helena Elding Larsson, Åke Lernmark, et al.
  (2018) Lakartidningen, 115 p.484-484
- Early deficits in insulin secretion, beta cell mass and islet blood perfusion precede onset of autoimmune type 1 diabetes in BioBreeding rats
  Anya Medina, Saba Parween, Sara Ullsten, Neelanjan Vishnu, Yuk Ting Siu, et al.
  (2018) Diabetologia, 61 p.896-905
- Pandemrix® vaccination is not associated with increased risk of islet autoimmunity or type 1 diabetes in the TEDDY study children
  Helena Elding Larsson, Kristian F. Lynch, Maria Lönnrot, Michael J Haller, Åke Lernmark, et al.
  (2018) Diabetologia, 61 p.193-202
- Caesarean Section on The Risk of Celiac Disease in the Offspring : The Teddy Study
  Sibylle Koletzko, Hye-Seung Lee, Andreas Beyerlein, Carin A. Aronsson, Michael Hummel, et al.
  (2018) Journal of Pediatric Gastroenterology and Nutrition, 66 p.417-424
- Gestational respiratory infections interacting with offspring HLA and CTLA-4 modifies incident β-cell autoantibodies
  Kristian F. Lynch, Hye-Seung Lee, Carina Törn, Kendra Vehik, Jeffrey P. Krischer, et al.
  (2018) Journal of Autoimmunity, 86 p.93-103
- Reduced display of conformational epitopes in the N-terminal truncated GAD65 isoform : relevance for people with stiff person syndrome or DQ8/8-positive Type 1 diabetes mellitus
  C. S. Hampe, J. R. Radtke, A. Wester, A. Carlsson, E. Cedervall, et al.
  (2018) Diabetic Medicine
- Plasma 25-Hydroxyvitamin D concentration and risk of islet autoimmunity
  Jill M. Norris, Hye Seung Lee, Brittni Frederiksen, Iris Erlund, Ulla Uusitalo, et al.
  (2018) Diabetes, 67 p.146-154
- The Environmental Determinants of Diabetes in the Young (TEDDY) Study: 2018 Update
  , Heikki Hyöty, Åke Lernmark, William Hagopian, Jin-Xiong She, et al.
  (2018) Current Diabetes Reports, 18
- Identification of non-HLA genes associated with development of islet autoimmunity and type 1 diabetes in the prospective TEDDY cohort
  Ashok Sharma, Xiang Liu, David Hadley, William Hagopian, Wei Min Chen, et al.
  (2018) Journal of Autoimmunity, 89 p.90-100
- Association Between Early-Life Antibiotic Use and the Risk of Islet or Celiac Disease Autoimmunity
  Kaisa M Kemppainen, Kendra Vehik, Kristian F Lynch, Helena Elding Larsson, Ronald J Canepa, et al.
  (2017) JAMA Pediatrics, 171 p.1217-1225
- Co-occurrence of Type 1 Diabetes and Celiac Disease Autoimmunity
  William Hagopian, Hye Seung Lee, Edwin Liu, Marian Rewers, Jin Xiong She, et al.
  (2017) Pediatrics, 140
- The Influence of Type 1 Diabetes Genetic Susceptibility Regions, Age, Sex, and Family History to the Progression from Multiple Autoantibodies to Type 1 Diabetes:A TEDDY Study Report : A TEDDY Study Report
  Jeffrey P. Krischer, Xiang Liu, Åke Lernmark, William A. Hagopian, Marian J. Rewers, et al.
  (2017) Diabetes, 66 p.3122-3129
- Genetic and environmental interactions modify the risk of diabetes-related autoimmunity by 6 years of age : The teddy study
  Jeffrey P. Krischer, Kristian F Lynch, Ake Lernmark, William A Hagopian, Marian J. Rewers, et al.
  (2017) Diabetes Care, 40 p.1194-1202
- Joint modeling of longitudinal autoantibody patterns and progression to type 1 diabetes : results from the TEDDY study
  Meike Köhler, Andreas Beyerlein, Kendra Vehik, Sonja Greven, Nikolaus Umlauf, et al.
  (2017) Acta Diabetologica, 54 p.1009-1017
- Antibody Affinity Against 2009 A/H1N1 Influenza and Pandemrix Vaccine Nucleoproteins Differs Between Childhood Narcolepsy Patients and Controls
  Alexander Lind, Eva Freyhult, Anita Ramelius, Tomas Olsson, Lisen Arnheim-Dahlström, et al.
  (2017) Viral Immunology, 30 p.590-600
- Respiratory infections are temporally associated with initiation of type 1 diabetes autoimmunity : the TEDDY study
  Maria Lönnrot, Kristian F. Lynch, Helena Elding Larsson, Åke Lernmark, Marian J. Rewers, et al.
  (2017) Diabetologia, 60 p.1931-1940
- Understanding and preventing type 1 diabetes through the unique working model of TrialNet
  Manuela Battaglia, Mark S Anderson, Jane H. Buckner, Susan M. Geyer, Peter A Gottlieb, et al.
  (2017) Diabetologia, 60 p.2139-2147
- Different DRB1*03 : 01-DQB1*02:01 haplotypes confer different risk for celiac disease
  S. Alshiekh, L. P. Zhao, Lernmark, Daniel E Geraghty, Asa T Naluai, et al.
  (2017) HLA, 90 p.95-101
- Building and validating a prediction model for paediatric type 1 diabetes risk using next generation targeted sequencing of class II HLA genes
  Lue Ping Zhao, Annelie Carlsson, Helena Elding Larsson, Gun Forsander, Sten A Ivarsson, et al.
  (2017) Diabetes/Metabolism Research and Reviews, 33
- The feasibility of salivary sample collection in an international pediatric cohort : The the TEDDY study
  Roswith Roth, Judith Baxter, Kendra Vehik, Diane Hopkins, Michael Killian, et al.
  (2017) Developmental Psychobiology, 59 p.658-667
- Early prediction of autoimmune (type 1) diabetes
  Simon E. Regnell, Åke Lernmark
  (2017) Diabetologia, 60 p.1370-1381
- Analgesic antipyretic use among young children in the TEDDY study : No association with islet autoimmunity
  Markus Lundgren, Leigh Johnson Steed, Roy N. Tamura, Berglind Jonsdottir, Patricia Gesualdo, et al.
  (2017) BMC Pediatrics, 17
- Type 1 diabetes mellitus
  Anastasia Katsarou, Soffia Gudbjörnsdottir, Araz Rawshani, Dana Dabelea, Ezio Bonifacio, et al.
  (2017) Nature Reviews Disease Primers, 3
- Maternal use of dietary supplements during pregnancy is not associated with coeliac disease in the offspring : The Environmental Determinants of Diabetes in the Young (TEDDY) study
  Jimin Yang, Roy N. Tamura, Carin Andrén Aronsson, Ulla M Uusitalo, Åke Lernmark, et al.
  (2017) British Journal of Nutrition, 117 p.466-472
- Psychological manifestations of celiac disease autoimmunity in young children
  Laura B. Smith, Kristian Lynch, Kalle Kurppa, Sibylle Koletzko, Jeffrey Krischer, et al.
  (2017) Pediatrics, 139
- First infant formula type and risk of islet autoimmunity in the environmental determinants of diabetes in the young (TEDDY) study
  Sandra Hummel, Andreas Beyerlein, Roy N. Tamura, Ulla Uusitalo, Carin Andŕen Aronsson, et al.
  (2017) Diabetes Care, 40 p.398-404
- An Increased Diagnostic Sensitivity of Truncated GAD65 Autoantibodies in Type 1 Diabetes May Be Related to HLA-DQ8
  Axel Wester, Hanna Skärstrand, Alexander Lind, Anita Ramelius, Annelie Carlsson, et al.
  (2017) Diabetes, 66 p.735-740
- Longitudinal analysis of hepatic transcriptome and serum metabolome demonstrates altered lipid metabolism following the onset of hyperglycemia in spontaneously diabetic BioBreeding rats
  Simon E. Regnell, Martin J Hessner, Shuang Jia, Lina Åkesson, Hans Stenlund, et al.
  (2017) PLoS ONE, 12
- Islet autoantibodies present in association with Ljungan virus infection in bank voles (Myodes glareolus) in northern Sweden
  Anna Warvsten, Martin Björnfors, Michael Arvidsson, Fariba Vaziri-Sani, Ida Jönsson, et al.
  (2017) Journal of Medical Virology, 89 p.24-31
- Thyroid and islet autoantibodies predict autoimmune thyroid disease already at Type 1 diabetes diagnosis
  Berglind Jonsdottir, Christer Larsson, Annelie Carlsson, Gun Forsander, Sten Anders Ivarsson, et al.
  (2017) The Journal of clinical endocrinology and metabolism, 102 p.1277-1285
- Residual beta-cell function in diabetes children followed and diagnosed in the TEDDY study compared to community controls
  Andrea K Steck, Helena Elding Larsson, Xiang Liu, Riitta Veijola, Jorma Toppari, et al.
  (2017) Pediatric Diabetes, 18 p.794-802
- Factors That Increase Risk of Celiac Disease Autoimmunity After a Gastrointestinal Infection in Early Life
  Kaisa M Kemppainen, Kristian F. Lynch, Edwin Liu, Maria Lönnrot, Ville Simell, et al.
  (2017) Clinical Gastroenterology and Hepatology, 15 p.5-702
- Increased DNA methylation variability in type 1 diabetes across three immune effector cell types
  Dirk S. Paul, Andrew E. Teschendorff, Mary A N Dang, Robert Lowe, Mohammed I. Hawa, et al.
  (2016) Nature Communications, 7
- Reversion of β-cell autoimmunity changes risk of type 1 diabetes : TEDDY study
  Kendra Vehik, Kristian F. Lynch, Desmond A. Schatz, Beena Akolkar, William Hagopian, et al.
  (2016) Diabetes Care, 39 p.1535-1542
- A Comparison of Rule-based Analysis with Regression Methods in Understanding the Risk Factors for Study Withdrawal in a Pediatric Study
  Mona Haghighi, Suzanne Bennett Johnson, Xiaoning Qian, Kristian F. Lynch, Kendra Vehik, et al.
  (2016) Scientific Reports, 6
- Growth and risk for islet autoimmunity and progression to type 1 diabetes in early childhood : The environmental determinants of diabetes in the young study
  Helena Elding Larsson, Kendra Vehik, Michael J. Haller, Xiang Liu, Beena Akolkar, et al.
  (2016) Diabetes, 65 p.1988-1995
- Complement gene variants in relation to autoantibodies to beta cell specific antigens and type 1 diabetes in the TEDDY Study
  Carina Törn, Xiang Liu, William Hagopian, Åke Lernmark, Olli Simell, et al.
  (2016) Scientific Reports, 6
- Genetic risk factors for type 1 diabetes
  Flemming Pociot, Åke Lernmark
  (2016) The Lancet, 387 p.2331-2339
- An Object-Oriented Regression for Building Disease Predictive Models with Multiallelic HLA Genes
  Lue Ping Zhao, Hamid Bolouri, Michael Zhao, Daniel E. Geraghty, Åke Lernmark
  (2016) Genetic Epidemiology, 40 p.315-332
- Pancreas volume and fat fraction in children with Type 1 diabetes
  SIMON ERINGSMARK REGNÉLL, P Peterson, L Trinh, P Broberg, P Leander, et al.
  (2016) Diabetic Medicine, 33 p.1374-1379
- Next generation sequencing reveals that HLA-DRB3, -DRB4 and -DRB5 may be associated with islet autoantibodies and risk for childhood type 1 diabetes.
  Lue Ping Zhao, Shehab Alshiekh, Annelie Carlsson, Helena Larsson, Gun Forsander, et al.
  (2016) Diabetes, 65 p.710-718
- Identification of Non-HLA Genes Associated with Celiac Disease and Country-Specific Differences in a Large, International Pediatric Cohort
  Ashok Sharma, Xiang Liu, David Hadley, William Hagopian, Edwin Liu, et al.
  (2016) PLoS ONE, 11 p.0152476-0152476
- Effects of Gluten Intake on Risk of Celiac Disease: a case-control study on a Swedish birth cohort.
  Carin Andrén Aronsson, Hye-Seung Lee, Sibylle Koletzko, Ulla Uusitalo, Jimin Yang, et al.
  (2016) Clinical Gastroenterology and Hepatology, 14 p.403-409
- Altered regulatory T cell phenotype in latent autoimmune diabetes of the adults (LADA)
  M. Radenkovic, C. Silver, J. Arvastsson, K. Lynch, Åke Lernmark, et al.
  (2016) Clinical and Experimental Immunology, 186 p.46-56
- Factors associated with longitudinal food record compliance in a paediatric cohort study.
  Jimin Yang, Kristian F Lynch, Ulla M Uusitalo, Kristina Foterek, Sandra Hummel, et al.
  (2015) Public Health Nutrition, p.1-10
- Elevated Serum GAD65 and GAD65-GADA Immune Complexes in Stiff Person Syndrome.
  Gucci Jijuan Gu Urban, Mikaela Friedman, Ping Ren, Carina Törn, Malin Fex, et al.
  (2015) Scientific Reports, 5
- A Functional Polymorphism of Ptpn22 Is Associated with Type 1 Diabetes in the BioBreeding Rat.
  Janice Sarmiento, Robert H Wallis, Terri Ning, Leili Marandi, Gary Chao, et al.
  (2015) Journal of Immunology, 194 p.615-629
- ZnT8 autoantibody epitope specificity and affinity examined with recombinant ZnT8 variant proteins in specific ZnT8R and ZnT8W autoantibody positive type 1 diabetes patients.
  Hanna Skärstrand, Ewa Krupinska, Tatu Haataja, Fariba Vaziri Sani, Jens Lagerstedt, et al.
  (2015) Clinical and Experimental Immunology, 179 p.220-229
- Cell-surface MHC density profiling reveals instability of autoimmunity-associated HLA
  Hiroko Miyadera, Jun Ohashi, Åke Lernmark, Toshio Kitamura, Katsushi Tokunaga
  (2015) Journal of Clinical Investigation, 125 p.275-291
- Prevalence of celiac disease autoimmunity in children with type 1 diabetes: regional variations across the Øresund strait between Denmark and southernmost Sweden.
  Emma Adlercreutz, Jannet Svensson, Dorthe Hansen, Karsten Buschard, Åke Lernmark, et al.
  (2015) Pediatric Diabetes, 16 p.504-509
- Association of Early Exposure of Probiotics and Islet Autoimmunity in the TEDDY Study.
  Ulla Uusitalo, Xiang Liu, Jimin Yang, Carin Andrén Aronsson, Sandra Hummel, et al.
  (2015) JAMA Pediatrics, p.1-9
- Predictors of Progression From the Appearance of Islet Autoantibodies to Early Childhood Diabetes: The Environmental Determinants of Diabetes in the Young (TEDDY).
  Andrea K Steck, Kendra Vehik, Ezio Bonifacio, Åke Lernmark, Anette-G Ziegler, et al.
  (2015) Diabetes Care, 38 p.808-813
- Non-HLA type 1 diabetes genes modulate disease risk together with HLA-DQ and islet autoantibodies.
  M Maziarz, W Hagopian, J P Palmer, C B Sanjeevi, I Kockum, et al.
  (2015) Genes and Immunity, 16 p.541-551
- Doubly reactive INS-IGF2 autoantibodies in children with newly diagnosed autoimmune (type 1) diabetes.
  Norio Kanatsuna, Ahmed Delli, Cecilia K Andersson, Anna-Lena Nilsson, Fariba Vaziri Sani, et al.
  (2015) Scandinavian Journal of Immunology, 82 p.361-369
- Serological evaluation of possible exposure to Ljungan virus and related parechovirus in autoimmune (type 1) diabetes in children.
  Anna-Lena Nilsson, Fariba Vaziri Sani, Per Broberg, A Elfaitouri, R Pipkorn, et al.
  (2015) Journal of Medical Virology, 87 p.1130-1140
- The 6 year incidence of diabetes-associated autoantibodies in genetically at-risk children: the TEDDY study
  Jeffrey P. Krischer, Kristian F. Lynch, Desmond A. Schatz, Jorma Ilonen, Åke Lernmark, et al.
  (2015) Diabetologia, 58 p.980-987
- A method for reporting and classifying acute infectious diseases in a prospective study of young children: TEDDY
  Maria Lönnrot, Kristian Lynch, Helena Larsson, Åke Lernmark, Marian Rewers, et al.
  (2015) BMC Pediatrics, 15
- Baseline heterogeneity in glucose metabolism marks the risk for type 1 diabetes and complicates secondary prevention.
  Helena Larsson, Christer Larsson, Åke Lernmark
  (2015) Acta Diabetologica, 52 p.473-481
- Early Childhood Gut Microbiomes Show Strong Geographic Differences Among Subjects at High Risk for Type 1 Diabetes.
  Kaisa M Kemppainen, Alexandria N Ardissone, Austin G Davis-Richardson, Jennie R Fagen, Kelsey A Gano, et al.
  (2015) Diabetes Care, 38 p.329-332
- Role of Type 1 diabetes associated SNPs on risk of autoantibody positivity in the TEDDY Study.
  Carina Törn, David Hadley, Hye-Seung Lee, William Hagopian, Åke Lernmark, et al.
  (2015) Diabetes, 64 p.1818-1829
- Magnetic resonance imaging reveals altered distribution of hepatic fat in children with type 1 diabetes compared to controls.
  Simon Regnell, Pernilla Peterson, Lena Trinh, Per Broberg, Peter Leander, et al.
  (2015) Metabolism, Clinical and Experimental, 64 p.872-878
- Plasma GAD65, a Marker for Early beta-Cell Loss After Intraportal Islet Cell Transplantation in Diabetic Patients
  Zhidong Ling, Pieter De Pauw, Daniel Jacobs-Tulleneers-Thevissen, Rui Mao, Pieter Gillard, et al.
  (2015) Journal of Clinical Endocrinology and Metabolism, 100 p.2314-2321
- Staging Presymptomatic Type 1 Diabetes: A Scientific Statement of JDRF, the Endocrine Society, and the American Diabetes Association.
  Richard A Insel, Jessica L Dunne, Mark A Atkinson, Jane L Chiang, Dana Dabelea, et al.
  (2015) Diabetes Care, 38 p.1964-1974
- Determination of 21-hydroxylase autoantibodies: inter-laboratory concordance in the Euradrenal International Serum Exchange Program
  Alberto Falorni, Vittorio Bini, Corrado Betterle, Annalisa Brozzetti, Luis Castano, et al.
  (2015) Clinical Chemistry and Laboratory Medicine, 53 p.1761-1770
- Dietary intake of soluble fiber and risk of islet autoimmunity by 5 y of age: results from the TEDDY study.
  Andreas Beyerlein, Xiang Liu, Ulla M Uusitalo, Minna Harsunen, Jill M Norris, et al.
  (2015) American Journal of Clinical Nutrition, 102 p.345-352
- Neuropeptide Y is a minor autoantigen in newly diagnosed type 1 diabetes patients.
  Hanna Skärstrand, Fariba Vaziri Sani, Ahmed Delli, Carina Törn, Helena Larsson, et al.
  (2015) Pediatric Diabetes, 16 p.621-628
- Antibodies to influenza virus A/H1N1 hemagglutinin in type 1 diabetes children diagnosed before, during and after the Swedish A(H1N1)pdm09 vaccination campaign 2009-2010.
  Matilda1 Svensson, Anita Ramelius, Anna-Lena Nilsson, Ahmed Delli, Helena Larsson, et al.
  (2014) Scandinavian Journal of Immunology, 79 p.137-148
- Biomarker discovery study design for type 1 diabetes in The Environmental Determinants of Diabetes in the Young (TEDDY) study
  Hye-Seung Lee, Brant R. Burkhardt, Wendy McLeod, Susan Smith, Chris Eberhard, et al.
  (2014) Diabetes/Metabolism Research Reviews, 30 p.424-434
- High plasma levels of islet amyloid polypeptide in young with new-onset of type 1 diabetes mellitus.
  Johan F Paulsson, Johnny Ludvigsson, Annelie Carlsson, Rosaura Casas, Gun Forsander, et al.
  (2014) PLoS ONE, 9
- Carl-David Agardh, 1946-2013.
  Leif Groop, Åke Lernmark, Jan Nilsson
  (2014) Diabetologia
- Variability in the CIITA gene interacts with HLA in multiple sclerosis.
  A Gyllenberg, F Piehl, L Alfredsson, J Hillert, I L Bomfim, et al.
  (2014) Genes and Immunity, 15 p.162-167
- Reduced morbidity at diagnosis and improved glycemic control in children previously enrolled in DiPiS follow-up
  Markus Lundgren, Åsa Sahlin, Camilla Svensson, Annelie Carlsson, Elisabeth Cedervall, et al.
  (2014) Pediatric Diabetes, 15 p.494-501
- Lack of evidence for a role of islet autoimmunity in the aetiology of canine diabetes mellitus.
  Kerstin M Ahlgren, Tove Fall, Nils Landegren, Lars Grimelius, Henrik von Euler, et al.
  (2014) PLoS ONE, 9
- GAD Autoantibody Affinity in Adult Patients With Latent Autoimmune Diabetes, the Study Participants of a GAD65 Vaccination Trial
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- Islet cell antibodies (ICA) identify autoimmunity in children with new onset diabetes mellitus negative for other islet cell antibodies.
  Cecilia K Andersson, Martin Kolmodin, Sten Ivarsson, Annelie Carlsson, Gun Forsander, et al.
  (2014) Pediatric Diabetes, 15 p.336-344
- A/H1N1 antibodies and TRIB2 autoantibodies in narcolepsy patients diagnosed in conjunction with the Pandemrix vaccination campaign in Sweden 2009-2010.
  Alexander Lind, Anita Ramelius, Tomas Olsson, Lisen Arnheim-Dahlström, Favelle Lamb, et al.
  (2014) Journal of Autoimmunity, 50 p.99-106
- Prevalence of obesity was related to HLA-DQ in 2-4-year-old children at genetic risk for type 1 diabetes.
  J Yang, Åke Lernmark, U M Uusitalo, K F Lynch, R Veijola, et al.
  (2014) International Journal of Obesity, 38 p.1491-1496
- Children followed in the TEDDY study are diagnosed with type 1 diabetes at an early stage of disease.
  Helena Larsson, Kendra Vehik, Patricia Gesualdo, Beena Akolkar, William Hagopian, et al.
  (2014) Pediatric Diabetes, 15 p.118-126
- Activating germline mutations in STAT3 cause early-onset multi-organ autoimmune disease.
  Sarah E Flanagan, Emma Haapaniemi, Mark A Russell, Richard Caswell, Hana Lango Allen, et al.
  (2014) Nature Genetics, 46 p.812-814
- Biobreeding rat islets exhibit reduced antioxidative defense and N-acetyl cysteine treatment delays type 1 diabetes
  Marika Bogdani, Angela M. Henschel, Sanjay Kansra, Jessica M. Fuller, Rhonda Geoffrey, et al.
  (2013) Journal of Endocrinology, 216 p.111-123
- Methods, quality control and specimen management in an international multicentre investigation of type 1 diabetes: TEDDY
  Kendra Vehik, Steven W. Fiske, Chad A. Logan, Daniel Agardh, Corrado Cilio, et al.
  (2013) Diabetes/Metabolism Research Reviews, 29 p.557-567
- Is there evidence for post-translational modification of beta cell autoantigens in the aetiology and pathogenesis of type 1 diabetes?
  Åke Lernmark
  (2013) Diabetologia, 56 p.2355-2358
- Thyroid autoimmunity in relation to islet autoantibodies and HLA-DQ genotype in newly diagnosed type 1 diabetes in children and adolescents.
  Berglind Jonsdottir, Cecilia K Andersson, Annelie Carlsson, Ahmed Delli, G Forsander, et al.
  (2013) Diabetologia, 56 p.1735-1742
- Decline in Titers of Anti-Idiotypic Antibodies Specific to Autoantibodies to GAD65 (GAD65Ab) Precedes Development of GAD65Ab and Type 1 Diabetes.
  Helena Larsson, Ida Jönsson, Åke Lernmark, Sten Ivarsson, Jared R Radtke, et al.
  (2013) PLoS ONE, 8
- Meta-Immunological Profiling of Children With Type 1 Diabetes Identifies New Biomarkers to Monitor Disease Progression
  Mario Galgani, Rosa Nugnes, Dario Bruzzese, Francesco Perna, Veronica De Rosa, et al.
  (2013) Diabetes, 62 p.2481-2491
- Immune therapy in type 1 diabetes mellitus.
  Åke Lernmark, Helena Larsson
  (2013) Nature Reviews Endocrinology, 9 p.92-103
- Triple specificity of ZnT8 autoantibodies in relation to HLA and other islet autoantibodies in childhood and adolescent type 1 diabetes.
  C Andersson, Fariba Vaziri Sani, Aj Delli, Bengt Lindblad, Annelie Carlsson, et al.
  (2013) Pediatric Diabetes, 14 p.97-105
- Decreased cord-blood phospholipids in young age at onset type 1 diabetes.
  Daria La Torre, Tulikki Seppänen-Laakso, Helena Larsson, Tuulia Hyötyläinen, Sten Ivarsson, et al.
  (2013) Diabetes, 62 p.3951-3956
- Next-generation sequencing for viruses in children with rapid-onset type 1 diabetes
  H-S Lee, T. Briese, C. Winkler, M. Rewers, E. Bonifacio, et al.
  (2013) Diabetologia, 56 p.1705-1711
- Glucose tolerance and beta-cell function in islet autoantibody-positive children recruited to a secondary prevention study.
  Cecilia K Andersson, Annelie Carlsson, Corrado Cilio, Elisabeth Cedervall, Sten Ivarsson, et al.
  (2013) Pediatric Diabetes, 14 p.341-349
- Residual beta cell function at diagnosis of type 1 diabetes in children and adolescents varies with gender and season
  U. Samuelsson, B. Lindblad, Annelie Carlsson, G. Forsander, Sten Ivarsson, et al.
  (2013) Diabetes/Metabolism Research Reviews, 29 p.85-89
- Autoimmunity against INS-IGF2 expressed in human pancreatic islets.
  Norio Kanatsuna, Jalal Taneera, Fariba Vaziri Sani, Nils Wierup, Helena Larsson, et al.
  (2013) Journal of Biological Chemistry, 288 p.29013-29023
- Neuropeptide Y autoantibodies in patients with long-term type 1 and type 2 diabetes and neuropathy.
  Hanna Skärstrand, L B Dahlin, Åke Lernmark, Fariba Vaziri Sani
  (2013) Journal of Diabetes and its Complications1992-01-01+01:00, 27 p.609-617
- Relationship Between Ljungan Virus Antibodies, HLA-DQ8, and Insulin Autoantibodies in Newly Diagnosed Type 1 Diabetes Children
  Anna-Lena Nilsson, Fariba Vaziri Sani, Cecilia K Andersson, Karin Larsson, Annelie Carlsson, et al.
  (2013) Viral Immunology, 26 p.207-215
- Decline of C-peptide during the first year after diagnosis of Type 1 diabetes in children and adolescents
  Johnny Ludvigsson, Annelie Carlsson, Ahmed Deli, Gun Forsander, Sten Ivarsson, et al.
  (2013) Diabetes Research and Clinical Practice, 100 p.203-209
- The environment and the origins of islet autoimmunity and Type 1 diabetes.
  S Eringsmark Regnéll, Åke Lernmark
  (2012) Diabetic medicine : a journal of the British Diabetic Association
- Antigenicity and epitope specificity of ZnT8 autoantibodies in type 1 diabetes.
  Hanna Skärstrand, Åke Lernmark, Fariba Vaziri Sani
  (2012) Scandinavian Journal of Immunology
- Zinc Transporter 8 Autoantibodies and Their Association With SLC30A8 and HLA-DQ Genes Differ Between Immigrant and Swedish Patients With Newly Diagnosed Type 1 Diabetes in the Better Diabetes Diagnosis Study.
  Ahmed Delli, Fariba Vaziri Sani, Bengt Lindblad, Helena Larsson, Annelie Carlsson, et al.
  (2012) Diabetes, 61 p.2556-2564
- HTR1A a Novel Type 1 Diabetes Susceptibility Gene on Chromosome 5p13-q13
  Samina Asad, Pernilla Nikamo, Alexandra Gyllenberg, Hedvig Bennet, Ola Hansson, et al.
  (2012) PLoS ONE, 7
- High levels of immunoglobulin E and a continuous increase in immunoglobulin G and immunoglobulin M by age in children with newly diagnosed type 1 diabetes
  Jannet Svensson, Stefanie Eising, Henrik Bindesbol Mortensen, Michael Christiansen, Inga Laursen, et al.
  (2012) Human Immunology, 73 p.17-25
- HLA-DQB1 genotypes and islet cell autoantibodies against GAD65 and IA-2 in relation to development of diabetes post partum in women with gestational diabetes mellitus.
  Anastasia Papadopoulou, Kristian Lynch, Eva Anderberg, Mona Landin-Olsson, Ida Jönsson, et al.
  (2012) Diabetes Research and Clinical Practice, 95 p.260-264
- Seroconversion to Islet Autoantibodies After Enterovirus Infection in Early Pregnancy.
  Sabina Rešić Lindehammer, Hanna Honkanen, William Allan Nix, Maarit Oikarinen, Kristian Lynch, et al.
  (2012) Viral Immunology, 25 p.254-261
- Association between autoantibodies to the Arginine variant of the Zinc transporter 8 (ZnT8) and stimulated C-peptide levels in Danish children and adolescents with newly diagnosed type 1 diabetes
  Marie Louise M. Andersen, Fariba Vaziri Sani, Ahmed Delli, Sven Porksen, Emma Jacobssen, et al.
  (2012) Pediatric Diabetes, 13 p.454-462
- Guías y recomendaciones para el diagnóstico y manejo de la Diabetes Mellitus
  David B. Sacks, Mark Arnold, George L. Bakris, David E. Bruns, Andrea Rita Horvath, et al.
  (2012) Acta Bioquimica Clinica Latinoamericana, 46 p.303-336
- Islet autoantibodies and residual beta cell function in type 1 diabetes children followed for 3-6 years
  J. S. Sorensen, Fariba Vaziri Sani, M. Maziarz, K. Kristensen, A. Ellerman, et al.
  (2012) Diabetes Research and Clinical Practice, 96 p.204-210
- Few differences in cytokines between patients newly diagnosed with type 1 diabetes and their healthy siblings
  Jannet Svensson, Stefanie Eising, David Michael Hougaard, Henrik Bindesbol Mortensen, Kristin Skogstrand, et al.
  (2012) Human Immunology, 73 p.1116-1126
- C-peptide in the classification of diabetes in children and adolescents.
  Johnny Ludvigsson, Annelie Carlsson, G Forsander, Sten Ivarsson, I Kockum, et al.
  (2012) Pediatric Diabetes, 13 p.45-50
- Low risk HLA-DQ and increased body mass index in newly diagnosed type 1 diabetes children in the Better Diabetes Diagnosis study in Sweden.
  Annelie Carlsson, I Kockum, Bengt Lindblad, Lisa Engleson, A Nilsson, et al.
  (2012) International Journal of Obesity, 36 p.718-724
- Guthrie card methylomics identifies temporally stable epialleles that are present at birth in humans
  Huriya Beyan, Thomas A. Down, Sreeram V. Ramagopalan, Kristina Uvebrant, Anita Ramelius, et al.
  (2012) Genome Research, 22 p.2138-2145
- Age-dependent variation of genotypes in MHC II transactivator gene (CIITA) in controls and association to type 1 diabetes
  A Gyllenberg, Samina Asad, F Piehl, Maria Swanberg, L Padyukov, et al.
  (2012) Genes and Immunity, 13 p.632-640
- Sustained glucagon-like peptide 1 expression from encapsulated transduced cells to treat obese diabetic rats
  Daniel H. Moralejo, Ofer Yanay, Kelly Kernan, Adam Bailey, Ake Lernmark, et al.
  (2011) Journal of Bioscience and Bioengineering, 111 p.383-387
- High-titer GAD65 autoantibodies detected in adult diabetes patients using a high efficiency expression vector and cold GAD65 displacement.
  Ida Jönsson, Kristian Lynch, Göran Hallmans, Åke Lernmark, Olov Rolandsson
  (2011) Autoimmunity, 44 p.129-136
- Vaccination against type 1 diabetes.
  Helena Elding Larsson, Åke Lernmark
  (2011) Journal of Internal Medicine1989-01-01+01:00, 269 p.626-635
- Correlations between islet autoantibody specificity and the SLC30A8 genotype with HLA-DQB1 and metabolic control in new onset type 1 diabetes
  Caroline Brorsson, Fariba Vaziri Sani, Regine Bergholdt, Stefanie Eising, Anita Ramelius, et al.
  (2011) Autoimmunity, 44 p.107-114
- Increased GABA(A) channel subunits expression in CD8(+) but not in CD4(+) T cells in BB rats developing diabetes compared to their congenic littermates
  Suresh Kumar Mendu, Lina Åkesson, Zhe Jin, Anna Edlund, Corrado Cilio, et al.
  (2011) Molecular Immunology, 48 p.399-407
- Serum metabolite signature predicts the acute onset of diabetes in spontaneously diabetic congenic BB rats
  Lina Åkesson, Johan Trygg, Jessica Fuller, Rasmus Madsen, Jon Gabrielsson, et al.
  (2011) Metabolomics, 7 p.593-603
- Position Statement Executive Summary: Guidelines and Recommendations for Laboratory Analysis in the Diagnosis and Management of Diabetes Mellitus
  David B. Sacks, Mark Arnold, George L. Bakris, David E. Bruns, Andrea Rita Horvath, et al.
  (2011) Diabetes Care, 34 p.1419-1423
- HLA Genes, Islet Autoantibodies and Residual C-Peptide at the Clinical Onset of Type 1 Diabetes Mellitus and the Risk of Retinopathy 15 Years Later
  Richard A. Jensen, Elisabet Agardh, Åke Lernmark, Soffia Gudbjornsdottir, Nicholas L. Smith, et al.
  (2011) PLoS ONE, 6
- Seroconversion to islet autoantibodies between early pregnancy and delivery in non-diabetic mothers
  Sabina Lindehammer, Ida Jönsson, Bo Midberg, Sten Ivarsson, Kristian Lynch, et al.
  (2011) Journal of Reproductive Immunology, 88 p.72-79
- BB rat Gimap gene expression in sorted lymphoid T and B cells
  Daniel H. Moralejo, Jessica Fuller, Elizabeth A. Rutledge, Brian Van Yserloo, Ruth A. Ettinger, et al.
  (2011) Life Sciences, 89 p.748-754
- Country-specific birth weight and length in type 1 diabetes high-risk HLA genotypes in combination with prenatal characteristics.
  Y Sterner, Carina Törn, H-S Lee, Helena Larsson, Christian Winkler, et al.
  (2011) Journal of Perinatology, 31 p.764-769
- Relationship between ZnT8Ab, the SLC30A8 gene and disease progression in children with newly diagnosed type 1 diabetes
  Lotte B. Nielsen, Fariba Vaziri Sani, Sven Poerksen, Marie-Louise M. Andersen, Jannet Svensson, et al.
  (2011) Autoimmunity, 44 p.616-623
- Gestational diabetes mellitus is associated with TCF7L2 gene polymorphisms independent of HLA-DQB1*0602 genotypes and islet cell autoantibodies.
  Anastasia Papadopoulou, Kristian Lynch, Nael Shaat, Rasmus Bennet, Sten Ivarsson, et al.
  (2011) Diabetic Medicine, 28 p.1018-1027
- The three ZNT8 autoantibody variants together improve the diagnostic sensitivity of childhood and adolescent type 1 diabetes.
  Cecilia K Andersson, Karin Larsson, Fariba Vaziri Sani, Kristian Lynch, Annelie Carlsson, et al.
  (2011) Autoimmunity, 44 p.394-405
- A novel triple mix radiobinding assay for the three ZnT8 (ZnT8-RWQ) autoantibody variants in children with newly diagnosed diabetes.
  Fariba Vaziri Sani, Ahmed Delli, Helena Larsson, Bengt Lindblad, Annelie Carlsson, et al.
  (2011) Journal of Immunological Methods, 371 p.25-37
- Early-Pregnancy Cytokines in Mothers to Children Developing Multiple, Persistent Islet Autoantibodies, Type 1 Diabetes, or Both Before 7 Years of Age.
  Sabina Lindehammer, Malin Fex, Marlena Maziarz, Ida Hanson, Karel Marsal, et al.
  (2011) American Journal of Reproductive Immunology, 66 p.495-503
- The Environmental Determinants of Diabetes in the Young (TEDDY): genetic criteria and international diabetes risk screening of 421 000 infants.
  William A Hagopian, Henry Erlich, Åke Lernmark, Marian Rewers, Anette G Ziegler, et al.
  (2011) Pediatric Diabetes, 12 p.733-743
- Guidelines and Recommendations for Laboratory Analysis in the Diagnosis and Management of Diabetes Mellitus
  David B. Sacks, Mark Arnold, George L. Bakris, David E. Bruns, Andrea Rita Horvath, et al.
  (2011) Clinical Chemistry, 57 p.1-47
- Danish children born with glutamic acid decarboxylase-65 and islet antigen-2 autoantibodies at birth had an increased risk to develop type 1 diabetes
  Stefanie Eising, Anita Ramelius, Bendix Carstensen, David M. Hougaard, Bent Norgaard-Pedersen, et al.
  (2011) European Journal of Endocrinology1994-01-01+01:00, 164 p.247-252
- Differential effects of leptin receptor mutation on male and female BBDR.Gimap5-/Gimap5- spontaneously diabetic rats
  Daniel H. Moralejo, Carl T. Hansen, Piper Treuting, Martin J Hessner, Jessica M. Fuller, et al.
  (2010) Physiological Genomics, 41 p.9-20
- The association between the PTPN22 1858C > T variant and type 1 diabetes depends on HLA risk and GAD65 autoantibodies
  M. Maziarz, M. Janer, J. C. Roach, W. Hagopian, J. P. Palmer, et al.
  (2010) Genes and Immunity, 11 p.406-415
- Prolonged survival and improved glycemia in BioBreeding diabetic rats after early sustained exposure to glucagon-like peptide
  Ofer Yanay, Daniel H. Moralejo, Kelly Kernan, Margaret Brzezinski, Jessica M. Fuller, et al.
  (2010) Journal of Gene Medicine, 12 p.538-544
- Changes in GAD65Ab-Specific Antiidiotypic Antibody Levels Correlate with Changes in C-Peptide Levels and Progression to Islet Cell Autoimmunity.
  E Ortqvist, B Brooks-Worrell, Kristian Lynch, J Radtke, L M Bekris, et al.
  (2010) The Journal of clinical endocrinology and metabolism, 95 p.310-318
- Identification of a serum-induced transcriptional signature associated with type 1 diabetes in the BioBreeding rat
  Mary L. Kaldunski, Shuang Jia, Rhonda Geoffrey, Joel Basken, Simon Prosser, et al.
  (2010) Diabetes, 59 p.2375-2385
- Altered natural killer (NK) cell frequency and phenotype in latent autoimmune diabetes in adults (LADA) prior to insulin deficiency.
  Christina Silver, K Uvebrant, Cecilia Oderup, Kristian Lynch, R A Harris, et al.
  (2010) Clinical and Experimental Immunology, May 4 p.48-56
- Comparison of Radioimmunoprecipitation With Luciferase Immunoprecipitation for Autoantibodies to GAD65 and IA-2 beta
  Peter D. Burbelo, Hiroki Hirai, Alexandra T. Issa, Albert Kingman, Åke Lernmark, et al.
  (2010) Diabetes Care, 33 p.754-756
- Context and disease when disease risk is low: the case of type 1 diabetes in Sweden
  Kristian Lynch, S. V. Subramanian, Henrik Ohlsson, Basile Chaix, Åke Lernmark, et al.
  (2010) Journal of Epidemiology and Community Health, 64 p.789-795
- ZnT8 autoantibody titers in type 1 diabetes patients decline rapidly after clinical onset.
  Fariba Vaziri Sani, Shilpa Oak, Jared Radtke, Åke Lernmark, Kristian Lynch, et al.
  (2010) Autoimmunity, Apr 7 p.598-606
- Immunology of beta-Cell Destruction.
  Daria La Torre, Åke Lernmark
  (2010) Advances in Experimental Medicine and Biology, 654 p.537-583
- Type 1 diabetes patients born to immigrants to Sweden increase their native diabetes risk and differ from Swedish patients in HLA types and islet autoantibodies.
  Ahmed Delli, Bengt Lindblad, Annelie Carlsson, Gun Forsander, Sten Ivarsson, et al.
  (2010) Pediatric Diabetes, Apr 8 p.513-520
- Genetic Dissection Reveals Diabetes Loci Proximal to the Gimap5 Lymphopenia Gene.
  Jessica Fuller, Marika Bogdani, Terry D Tupling, Richard A Jensen, Ranae Pefley, et al.
  (2009) Physiological Genomics, 38 p.89-97
- Low agreement between radio binding assays in analyzing glutamic acid decarboxylase (GAD65Ab) autoantibodies in patients classified with type 2 diabetes
  Bledar Daka, Maria K. Svensson, Åke Lernmark, Lucia Mincheva-Nilsson, Goran Hallmans, et al.
  (2009) Autoimmunity, 42 p.507-514
- The non-inherited maternal HLA haplotype affects the risk for type 1 diabetes
  Kristina Åkesson, Annelie Carlsson, S. -A. Ivarsson, C. Johansson, B. -M. Weidby, et al.
  (2009) International Journal of Immunogenetics, 36 p.1-8
- Comparison of three assays for the detection of GAD65Ab-specific anti-idiotypic antibodies
  Shilpa Oak, Jared Radtke, Mona Landin-Olsson, Carina Törn, Åke Lernmark, et al.
  (2009) Journal of Immunological Methods, 351 p.55-61
- Sequence Variation and Expression of the Gimap Gene Family in the BB Rat
  Elizabeth A. Rutledge, Jessica Fuller, Brian Van Yserloo, Daniel H. Moralejo, Ruth A. Ettinger, et al.
  (2009) Experimental Diabetes Research
- Analysis of the rat Iddm14 diabetes susceptibility locus in multiple rat strains: identification of a susceptibility haplotype in the Tcrb-V locus
  John P. Mordes, Laura Cort, Elaine Norowski, Jean Leif, Jessica Fuller, et al.
  (2009) Mammalian Genome, 20 p.162-169
- GAD65 vaccination: 5 years of follow-up in a randomised dose-escalating study in adult-onset autoimmune diabetes.
  Carl-David Agardh, Kristian Lynch, M Palmér, Katarina Link, Åke Lernmark
  (2009) Diabetologia, 52 p.1363-1368
- The type 1 diabetes protective HLA DQB1*0602 allele is less frequent in gestational diabetes mellitus.
  Anastasia Papadopoulou, Kristian Lynch, Nael Shaat, Anita Nilsson, Barbro Lernmark, et al.
  (2009) Diabetologia, 52 p.1339-1342
- Temporal Variation of Ljungan Virus Antibody Levels in Relation to Islet Autoantibodies and Possible Correlation to Childhood Type 1 Diabetes
  Anna-Lena Nilsson, Eliza Lagerquist, Kristian Lynch, Åke Lernmark, Rolandsson Olov
  (2009) Open Pediatric Medicine Journal, 3 p.61-66
- Treatment of diabetic rats with encapsulated islets
  Ian R. Sweet, Ofer Yanay, Lanaya Waldron, Merle Gilbert, Jessica M. Fuller, et al.
  (2008) Journal of Cellular and Molecular Medicine, 12 p.2644-2650
- Impaired survival of peripheral T cells, disrupted NK/NKT cell development, and liver failure in mice lacking Gimap5
  Ryan D. Schulteis, Haiyan Chu, Xuezhi Dai, Yuhong Chen, Brandon Edwards, et al.
  (2008) Blood, 112 p.4905-4914
- Antigen presentation of detergent-free glutamate decarboxylase (GAD65) is affected by human serum albumin as carrier protein
  Jordan T Steed, Lisa K Gilliam, Robert A Harris, Åke Lernmark, Christiane S Hampe
  (2008) Journal of Immunological Methods, 334 p.114-121
- Increased Lipid Oxidation Heralds Diabetes Onset in DR.lyp/lyp Rats.
  Lina Åkesson, R Gelling, R Jensen, K Ogimoto, J Fuller, et al.
  (2008) Experimental and Clinical Endocrinology & Diabetes1995-01-01+01:00, 116 p.475-480
- A comparison of serum and EDTA plasma in the measurement of glutamic acid decarboxylase autoantibodies (GADA) and autoantibodies to islet antigen-2 (IA-2A) using the RSR radioimmunoassay (RIA) and enzyme linked immunosorbent assay (ELISA) kits.
  Kobra Rahmati, Åke Lernmark, Charlotte Becker, Anna Foltyn Zadura, Karin Larsson, et al.
  (2008) Clinical Laboratory, 54 p.227-235
- Children developing type 1 diabetes before 6 years of age have increased linear growth independent of HLA genotypes.
  Helena Larsson, Gertie Hansson, Annelie Carlsson, E Cederwall, B Jonsson, et al.
  (2008) Diabetologia, 51 p.1623-1630
- Number of islet autoantibodies present in newly diagnosed type 1 diabetes children born to non-diabetic mothers is affected by islet autoantibodies present at birth.
  Maria Elfving, Bengt Lindberg, Kristian Lynch, Majvi Månsson, Göran Sundkvist, et al.
  (2008) Pediatric Diabetes, 9 p.127-134
- HLA class II alleles specify phenotypes of ketosis-prone diabetes
  Ramaswami Nalini, Lakshmi K Gaur, Mario Maldonado, Christiane S Hampe, Lucille Rodriguez, et al.
  (2008) Diabetes Care, 31 p.1195-1200
- Temporal trends of HLA genotype frequencies of type 1 diabetes patients in Sweden from 1986 to 2005 suggest altered risk.
  Sabina Lindehammer, Karin Larsson, Eva Örtqvist, Annelie Carlsson, E Cederwall, et al.
  (2008) Acta Diabetologica, Sep 4 p.231-235
- Annual screening detects celiac disease in children with type 1 diabetes
  Karin Larsson, Annelie Carlsson, Elisabeth Cederwall, Bjorn Jonsson, Jan Neiderud, et al.
  (2008) Pediatric Diabetes, 9 p.354-359
- Cord blood islet autoantibodies and seasonal association with the type 1 diabetes high-risk genotype.
  Kristian Lynch, Barbro Lernmark, Juan Merlo, Maria Roberta Cilio, S-A Ivarsson, et al.
  (2008) Journal of Perinatology, 28 p.211-217
- Selective screening of secretory vesicle-associated proteins for autoantigens in type 1 diabetes: VAMP2 and NPY are new minor autoantigens
  Hiroki Hirai, Junnosuke Miura, Yafang Hu, Helena Larsson, Karin Larsson, et al.
  (2008) Clinical Immunology1999-01-01+01:00, 127 p.366-374
- Maternal enterovirus infection during pregnancy as a risk factor in offspring diagnosed with type 1 diabetes between 15 and 30 years of age.
  Maria Elfving, Johan Svensson, Sami Oikarinen, Björn Jonsson, Per Olofsson, et al.
  (2008) Experimental Diabetes Research, 2008
- Cutaneous Microvascular Dysfunction Is Associated With Human Leukocyte Antigen-DQ in Youths With Type 1 Diabetes.
  Michal Odermarsky, Åke Lernmark, Lennart Truedsson, Petru Liuba
  (2008) Pediatric Research, 63 p.420-422
- Two insulin gene single nucleotide polymorphisms associated with type 1 diabetes risk in the Finnish and Swedish populations
  Antti-Pekka Laine, Hanna Holmberg, Anita Ramelius, E. Ortqvist, Minna Kiviniemi, et al.
  (2007) Disease Markers, 23 p.139-145
- A variant in the transcription factor 7-like 2 (TCF7L2) gene is associated with an increased risk of gestational diabetes mellitus.
  Nael Shaat, Åke Lernmark, Ella Ekholm, Sten Ivarsson, Hemang Parikh, et al.
  (2007) Diabetologia, 50 p.972-979
- Low-density cells isolated from the rat thymus resemble branched cortical macrophages and have a reduced capability of rescuing double-positive thymocytes from apoptosis in the BB-DP rat.
  V Sommandas, EA Rutledge, B Van Yserloo, J Fuller, Åke Lernmark, et al.
  (2007) J Leukoc Biol., 4 p.869-876
- Glutamate cysteine ligase catalytic subunit promoter polymorphisms and associations with type 1 diabetes age-at-onset and GAD65 autoantibody levels.
  LM Bekris, C Shephard, M Janer, J Graham, B McNeney, et al.
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- Relative predispositional effects of HLA class II DRB1-DQB1 haplotypes and genotypes on type 1 diabetes: a meta-analysis.
  G Thomson, AM Valdes, JA Noble, I Kockum, MN Grote, et al.
  (2007) Tissue Antigens, 70 p.110-127
- The importance of CTLA-4 polymorphism and human leukocyte antigen genotype for the induction of diabetes-associated cytokine response in healthy school children.
  CO Jonson, Åke Lernmark, J Ludvigsson, EA Rutledge, A Hinkkanen, et al.
  (2007) Pediatr Diabetes, 8 p.185-192
- Multiple factors affect the loss of measurable C-peptide over 6 years in newly diagnosed 15- to 35-year-old diabetic subjects
  Richard A. Jensen, Lisa K. Gilliam, Carina Törn, Mona Landin-Olsson, F. Anders Karlsson, et al.
  (2007) Journal of Diabetes and its Complications1992-01-01+01:00, 21 p.205-213
- Decreased core temperature and Increased beta(3)-Adrenergic sensitivity in diabetes-prone BB rats
  Lina Åkesson, Tyson Hawkins, Richard Jensen, Jessica M. Fuller, Norman E. Breslow, et al.
  (2007) Diabetes Technology & Therapeutics, 9 p.354-362
- Type 1 diabetes risk analysis on dried blood spot samples from population-based newborns: design and feasibility of an unselected case-control study
  Stefanie Eising, Jannet Svensson, Kristin Skogstrand, Anita Ramelius, Kristian Lynch, et al.
  (2007) Paediatric and Perinatal Epidemiology, 21 p.507-517
- Islet cell autoantibody levels after the diagnosis of young adult diabetic patients
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  (2007) Diabetic Medicine, 24 p.1221-1228
- No evidence of association of the PDCD1 gene with Type 1 diabetes
  S. Fawwaz, P. Nikamo, Carina Törn, Mona Landin-Olsson, Åke Lernmark, et al.
  (2007) Diabetic Medicine, 24 p.1473-1477
- Atherogenic vascular and lipid phenotypes in young patients with Type 1 diabetes are associated with diabetes high-risk HLA genotype
  Michal Odermarsky, Anita Ramelius, Åke Lernmark, Sture Sjöblad, Petru Liuba
  (2007) American Journal of Physiology: Heart and Circulatory Physiology, 293 p.3175-3179
- IA-2 autoantibodies in incident type I diabetes patients are associated with a polyadenylation signal polymorphism in GIMAP5.
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  (2007) Genes Immun., 8 p.503-512
- Antibodies to GAD65 and peripheral nerve function in the DCCT.
  RD Hoeldtke, CS Hampe, LM Bekris, G Hobbs, KD Bryner, et al.
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- Species and epitope specificity of two 65 kDa glutamate decarboxylase time-resolved fluorometric immunoassays.
  M Rui, CS Hampe, C Wang, Z Ling, FK Gorus, et al.
  (2007) Journal of Immunological Methods, 319 p.133-143
- GAD65 autoantibody epitopes in adult patients with latent autoimmune diabetes following GAD65 vaccination
  L. M. Bekris, R. A. Jensen, E. Lagerquist, T. R. Hall, Carl-David Agardh, et al.
  (2007) Diabetic Medicine, 24 p.521-526
- Epitope Analysis of GAD65 Binding in both Cord Blood and at the Time of Clinical Diagnosis of Childhood Type 1 Diabetes.
  Maria Elfving, Bengt Lindberg, Kristian Lynch, Sten Ivarsson, Åke Lernmark, et al.
  (2007) Hormone and Metabolic Research, 39 p.790-796
- The environmental determinants of diabetes in the young (TEDDY) study: Study design
  The TEDDY study group, Åke Lernmark, Peter Almgren, Carin Andrén Aronsson, Eva Andersson, et al.
  (2007) Pediatric Diabetes, 8 p.286-298
- Relationship between increased relative birthweight and infections during pregnancy in children with a high-risk diabetes HLA genotype.
  Helena Larsson, Kristian Lynch, Barbro Lernmark, Gertie Hansson, Åke Lernmark, et al.
  (2007) Diabetologia, 50 p.1161-1169
- Increased galanin expression in the celiac ganglion of BB diabetic rats
  Qi Mei, Thomas O Mundinger, Åke Lernmark, Gerald J Taborsky
  (2006) Neuropeptides, 40 p.1-10
- Accuracy and predictive value of classification schemes for ketosis-prone diabetes
  Ashok Balasubramanyam, Gilberto Garza, Lucille Rodriguez, Christiane S Hampe, Lakshmi K Gaur, et al.
  (2006) Diabetes Care, 29 p.2575-2579
- Genetic mapping at 3-kilobase resolution reveals inositol 1,4,5-triphosphate receptor 3 as a risk factor for type 1 diabetes in Sweden.
  J C Roach, K Deutsch, S Li, A F Siegel, L M Bekris, et al.
  (2006) American Journal of Human Genetics, 79 p.614-627
- Introgression of F344 rat genomic DNA on BB rat chromosome 4 generates diabetes-resistant lymphopenic BB rats.
  Jessica Fuller, A E Kwitek, T J Hawkins, D H Moralejo, W Lu, et al.
  (2006) Diabetes, 55 p.3351-3357
- Cord blood islet autoantibodies are related to stress in the mother during pregnancy.
  Barbro Lernmark, Kristian Lynch, Åke Lernmark, DiPiS Study Group
  (2006) Annals of the New York Academy of Sciences, 1079 p.345-349
- MHC class I chain-related gene-A is associated with IA2 and IAA but not GAD in Swedish type 1 diabetes mellitus
  Manu Gupta, Jinko Graham, Brian McNeeny, Marian Zarghami, Mona Landin-Olsson, et al.
  (2006) Annals of the New York Academy of Sciences, 1079 p.229-239
- Targeting type 1 diabetes before and at the clinical onset of disease.
  L M Bekris, T J Kavanagh, Åke Lernmark
  (2006) Endocrine, Metabolic & Immune Disorders - Drug Targets, 6 p.103-124
- Reduction of tissue transglutaminase autoantibody levels by gluten-free diet is associated with changes in subsets of peripheral blood lymphocytes in children with newly diagnosed coeliac disease.
  Daniel Agardh, Kristian Lynch, Charlotte Brundin, S-A Ivarsson, Åke Lernmark, et al.
  (2006) Clinical and Experimental Immunology, 144 p.67-75
- Common variants in MODY genes increase the risk of gestational diabetes mellitus.
  Nael Shaat, Ella Ekholm, Åke Lernmark, Sten Ivarsson, Kristian Lynch, et al.
  (2006) Diabetologia, 49 p.1545-1551
- TEDDY- The environmental determinants of diabetes in the young - An observational clinical trial
  William A. Hagopian, Åke Lernmark, Marian J. Rewers, Olli G. Simell, Jin-Xiong She, et al.
  (2006) Annals of the New York Academy of Sciences, 1079 p.320-326
- Evidence for immunological priming and increased frequency of CD4(+) CD25(+) cord blood T cells in children born to mothers with type 1 diabetes.
  B C Holm, J Svensson, Christina Silver, Jeanette Arvastsson, June Ljungberg, et al.
  (2006) Clinical and Experimental Immunology, 146 p.493-502
- Evidence of a functional role for mast cells in the development of type 1 diabetes mellitus in the biobreeding rat
  Rhonda Geoffrey, Shuang Jia, Anne E. Kwitek, Jeffrey Woodliff, Soumitra Ghosh, et al.
  (2006) Journal of Immunology, 177 p.7275-7286
- Prenatal viral exposure followed by adult stress produces glucose intolerance in a mouse model.
  B Niklasson, A Samsioe, M Blixt, S Sandler, A Sjöholm, et al.
  (2006) Diabetologia, 49 p.2192-2199
- Age-dependent loss of tolerance to an immunodominant epitope of glutamic acid decarboxylase in diabetic-prone RIP-B7/DR4 mice.
  John A Gebe, Kellee A Unrath, Ben A Falk, Ito Kouichi, Li Wen, et al.
  (2006) Clinical Immunology1999-01-01+01:00, 121 p.294-304
- Effects of duration of type 2 diabetes mellitus on insulin secretion.
  F Zangeneh, P S Arora, P J Dyck, L Bekris, Åke Lernmark, et al.
  (2006) Endocrine Practice, 12 p.388-393
- Increased risk of diabetes among relatives of female insulin-treated patients diagnosed at 15-34 years of age.
  K Åkesson, L Nyström, L Färnkvist, J Ostman, Åke Lernmark, et al.
  (2005) Diabetic Medicine, 22 p.1551-1557
- Autoantibodies Against Soluble and Immobilized Human Recombinant Tissue Transglutaminase in Children with Celiac Disease.
  Daniel Agardh, Ingrid Dahlbom, Terri Daniels, Ester Lörinc, Sten Ivarsson, et al.
  (2005) Journal of Pediatric Gastroenterology and Nutrition - Jpgn, 41 p.322-327
- Calcium activation of tissue transglutaminase in radioligand binding and enzyme-linked autoantibody immunoassays in childhood celiac disease.
  Daniel Agardh, Bodil Roth, Åke Lernmark, Pål Stenberg
  (2005) Clinica Chimica Acta, 358 p.95-103
- Glutathione-s-transferase M1 and T1 polymorphisms and associations with type 1 diabetes age-at-onset.
  L M Bekris, C Shephard, M Peterson, J Hoehna, B Van Yserloo, et al.
  (2005) Autoimmunity, 38 p.567-575
- DR.lyp/lyp bone marrow maintains lymphopenia and promotes diabetes in lyp/lyp but not in +/+ recipient DR.lyp BB rats
  T Hawkins, J Fuller, K Olson, S Speros, Åke Lernmark
  (2005) Journal of Autoimmunity, 25 p.251-257
- Autoantibodies in diabetes.
  C Pihoker, L K Gilliam, C S Hampe, Åke Lernmark
  (2005) Diabetes, 54 p.52-61
- Defects in differentiation of bone-marrow derived dendritic cells of the BB rat are partly associated with IDDM2 (the lyp gene) and partly associated with other genes in the BB rat background.
  V Sommandas, E A Rutledge, B Van Yserloo, J Fuller, Åke Lernmark, et al.
  (2005) Journal of Autoimmunity, 25 p.46-56
- Association of the E23K polymorphism in the KCNJ11 gene with gestational diabetes mellitus.
  Nael Shaat, M Ekelund, Åke Lernmark, Sten Ivarsson, Peter Almgren, et al.
  (2005) Diabetologia, 48 p.2544-2551
- Epitope analysis of insulin autoantibodies using recombinant Fab
  C J Padoa, N J Crowther, J W Thomas, T R Hall, L M Bekris, et al.
  (2005) Clinical and Experimental Immunology, 140 p.564-571
- Medicinska biobanken - en unik resurs för medicinsk forskning
  T Stigbrand, L Rymo, Åke Lernmark
  (2005) Läkartidningen, 102 p.2769-2772
- Clinical evidence for the safety of GAD65 immunomodulation in adult-onset autoimmune diabetes.
  Carl-David Agardh, Corrado M Cilio, ÅsaLinda Lethagen, Kristian Lynch, R David G Leslie, et al.
  (2005) Journal of Diabetes and its Complications1992-01-01+01:00, 19 p.238-246
- Involvement of eotaxin, eosinophils, and pancreatic predisposition in development of type 1 diabetes mellitus in the BioBreeding rat.
  Martin J Hessner, Xujing Wang, Lisa Meyer, Rhonda Geoffrey, Shuang Jia, et al.
  (2004) Journal of Immunology, 173 p.6993-7002
- A high prevalence of organ-specific autoimmunity in patients with bipolar disorder.
  Roos C Padmos, Lynn Bekris, Esther M Knijff, Henning Tiemeier, Ralph W Kupka, et al.
  (2004) Biological Psychiatry, 56 p.476-482
- Non-invasive imaging of beta cell mass: a quantitative analysis.
  Ian R Sweet, Daniel L Cook, Åke Lernmark, Carla J Greenbaum, Kenneth A Krohn
  (2004) Diabetes Technology & Therapeutics, 6 p.652-659
- Epitope-restricted 65-kilodalton glutamic acid decarboxylase autoantibodies among new-onset Sardinian type 2 diabetes patients define phenotypes of autoimmune diabetes.
  Mario Maioli, Emilyn Alejandro, Giancarlo Tonolo, Lisa K. Gilliam, Lynn Bekris, et al.
  (2004) Journal of Clinical Endocrinology and Metabolism, 89 p.5675-5682
- HLA-DRB1, -DQA1, and -DQB1 subtypes or ACE gene polymorphisms do not seem to be risk markers for severe retinopathy in younger Type 1 diabetic patients.
  Elisabet Agardh, Lakshmi K Gaur, Åke Lernmark, Carl-David Agardh
  (2004) Journal of Diabetes and its Complications1992-01-01+01:00, 18 p.32-36
- Preface.
  A L Notkins, Åke Lernmark, D Leslie
  (2004) Autoimmunity, 37 p.251-251
- Systematic screening of potential beta-cell imaging agents.
  Ian R Sweet, Carla J. Cook, Åke Lernmark, Carla J. Greenbaum, Angela R Wallen, et al.
  (2004) Biochemical and Biophysical Research Communications, 314 p.976-983
- Transgenic rescue demonstrates involvement of the Ian5 gene in T cell development in the rat.
  Mieczyslaw Michalkiewicz, Teresa Michalkiewicz, Ruth A. Ettinger, Elizabeth A. Rutledge, Jessica M. Fuller, et al.
  (2004) Physiological Genomics, 19 p.228-232
- Development of glutamic acid decarboxylase 65 (GAD65) autoantibody assay using biotin-GAD65 fusion protein.
  Dong Luo, Chad N Rogers, Jordan T Steed, Lisa K Gilliam, Christiane S Hampe, et al.
  (2004) Journal of Biotechnology, 111 p.97-104
- Using radioligand-binding assays to measure tissue transglutaminase autoantibodies in young children.
  Daniel Agardh, Annelie Carlsson, Kristian Lynch, Irene Axelsson, Åke Lernmark, et al.
  (2004) Acta Pædiatrica, 93 p.1046-1051
- Aberrancies in the differentiation and maturation of dendritic cells from bone-marrow precursors are linked to various genes on chromosome 4 and other chromosomes of the BB-DP rat.
  Vinod Sommandas, Elizabeth A. Rutledge, Brian Van Yserloo, Jessica Fuller, Åke Lernmark, et al.
  (2004) Journal of Autoimmunity, 25 p.1-12
- Genotypic and phenotypic differences between Arabian and Scandinavian women with gestational diabetes mellitus.
  Nael Shaat, M. Ekelund, Åke Lernmark, Sten Ivarsson, A. Nilsson, et al.
  (2004) Diabetologia, 47 p.878-884
- Standardization of antibody preparations for use in immunogenicity studies: a case study using the World Health Organization International Collaborative Study for Islet Cell Antibodies.
  A Mire-Sluis, R Gaines Das, Åke Lernmark
  (2003) Developments in Biologicals, 112 p.153-163
- Bead injection ELISA for the determination of antibodies implicated in type 1 diabetes mellitus.
  Andrea D Carroll, Louis Scampavia, Dong Luo, Åke Lernmark, Jaromir Ruzicka
  (2003) Analyst, 128 p.1157-1162
- Molecular engineering of biotin-glutamic acid decarboxylase 65 fusion protein (Biotin-GAD65) for non-radioactive GAD65 antibody assay
  Dong Luo, Chad N Rogers, Christiane S Hampe, Åke Lernmark
  (2003) Journal of Biotechnology, 103 p.249-255
- Islet autoantibodies in cord blood from patients who developed type 1 diabetes mellitus at 15-30 years of age.
  Maria Elfving, Bengt Lindberg, Lennarth Nyström, Göran Sundkvist, Åke Lernmark, et al.
  (2003) Autoimmunity, 36 p.227-231
- Impaired glucagon response to sympathetic nerve stimulation in the BB diabetic rat: effect of early sympathetic islet neuropathy.
  Thomas O Mundinger, Qi Mei, Dianne P Figlewicz, Åke Lernmark, Gerald J Jr Taborsky
  (2003) American Journal of Physiology: Endocrinology and Metabolism, 285 p.1047-1054
- Ketosis-prone diabetes: dissection of a heterogeneous syndrome using an immunogenetic and beta-cell functional classification, prospective analysis, and clinical outcomes
  Mario Maldonado, Christiane S Hampe, Lakshmi K Gaur, Susana D'Amico, Dinakar Iyer, et al.
  (2003) Journal of Clinical Endocrinology and Metabolism, 88 p.5090-5098
- Development of type 1 diabetes in wild bank voles associated with islet autoantibodies and the novel ljungan virus.
  Bo Niklasson, Knud E Heller, Bryan Schønecker, Mogens Bildsøe, Terri Daniels, et al.
  (2003) International journal of experimental diabesity research, 4 p.35-44
- High GAD65 autoantibody levels in nondiabetic adults are associated with HLA but not with CTLA-4 or INS VNTR.
  O Rolandsson, E Hägg, M Janer, E Rutledge, L K Gaur, et al.
  (2003) Journal of Internal Medicine1989-01-01+01:00, 253 p.447-453
- Type 1 diabetes in Swedish bank voles (Clethrionomys glareolus): signs of disease in both colonized and wild cyclic populations at peak density.
  Bo Niklasson, Birger Hörnfeldt, Erik Nyholm, Matthias Niedrig, Oliver Donoso-Mantke, et al.
  (2003) Annals of the New York Academy of Sciences, 1005 p.170-175
- Unique epitopes of glutamic acid decarboxylase autoantibodies in slowly progressive type 1 diabetes.
  Tetsuro Kobayashi, Shoichiro Tanaka, Minoru Okubo, Koji Nakanishi, Toshio Murase, et al.
  (2003) Journal of Clinical Endocrinology and Metabolism, 88 p.4768-4775
- Tissue transglutaminase immunoglobulin isotypes in children with untreated and treated celiac disease
  Daniel Agardh, Stefan Borulf, Åke Lernmark, Sten Ivarsson
  (2003) Journal of Pediatric Gastroenterology and Nutrition - Jpgn, 36 p.77-82
- Genetic dissection of lymphopenia from autoimmunity by introgression of mutated Ian5 gene onto the F344 rat.
  Daniel H Moralejo, Hyunhee A Park, Sara J Speros, Armand J MacMurray, Anne E Kwitek, et al.
  (2003) Journal of Autoimmunity, 21 p.315-324
- GAD2 on chromosome 10p12 is a candidate gene for human obesity.
  Philippe Boutin, Christian Dina, Francis Vasseur, Séverine Dubois, Laetitia Corset, et al.
  (2003) PLoS Biology, 1
- Induction of islet allotolerance in nonhuman primates
  Lakshmi K Gaur, Y Nitta, E. Kennedy, Å Lernmark, Keith A. Nelson, et al.
  (2002) Annals of the New York Academy of Sciences, 958 p.199-203
- Macrophages from high-risk HLA-DQB1*0201/*0302 type 1 diabetes mellitus patients are hypersensitive to lipopolysaccharide stimulation.
  A Plesner, C J Greenbaum, L K Gaur, R K Ernst, Åke Lernmark
  (2002) Scandinavian Journal of Immunology, 56 p.522-529
- Dynamic perifusion to maintain and assess isolated pancreatic islets.
  I R Sweet, D L Cook, R W Wiseman, C J Greenbaum, Åke Lernmark, et al.
  (2002) Diabetes Technology & Therapeutics, 4 p.67-76
- GAD65 and IA-2 autoantibodies are common in a subset of siblings of Sardinian Type 2 diabetes families.
  Mario Maioli, G Tonolo, L Bekris, R Cirillo, D Schranz, et al.
  (2002) Diabetes Research and Clinical Practice, 56 p.41-47
- Lymphopenia in the BB rat model of type 1 diabetes is due to a mutation in a novel immune-associated nucleotide (Ian)-related gene.
  Armand J. MacMurray, Daniel H. Moralejo, Anne E. Kwitek, Elizabeth A. Rutledge, Brian Van Yserloo, et al.
  (2002) Genome Research, 12 p.1029-1039
- Stable GAD65 autoantibody epitope patterns in type 1 diabetes children five years after onset.
  CS Hampe, LP Hammerle, L Bekris, E Ortqvist, B Persson, et al.
  (2002) Journal of Autoimmunity, 18 p.49-53
- Protein-free diets do not protect high-incidence diabetes-prone BioBreeding rats from diabetes.
  W Simonson, S Ramanathan, S Bieg, P Poussier, Åke Lernmark
  (2002) Metabolism: Clinical and Experimental, 51 p.569-574
- Type 1 diabetes as a model for prediction and diagnosis.
  Åke Lernmark
  (2002) Autoimmunity, 37 p.341-345
- Induction of donor-specific tolerance to islet allografts in nonhuman primates.
  LK Gaur, E Kennedy, Y Nitta, GT Nepom, KA Nelson, et al.
  (2002) Annals of the New York Academy of Sciences, 958 p.194-198
- Animal models of endocrine/organ-specific autoimmune diseases: do they really help us to understand human autoimmunity?
  WK Lam-Tse, Åke Lernmark, HA Drexhage
  (2002) Springer Seminars in Immunopathology1978-01-01+01:002006-01-01+01:00, 24 p.297-321
- Streptozotocin induced diabetes in minipig: a case report of a possible model for type 1 diabetes?
  O Rolandsson, M F Haney, E Hagg, B Biber, Åke Lernmark
  (2002) Autoimmunity, 35 p.261-264
- Early, selective, and marked loss of sympathetic nerves from the islets of BioBreeder diabetic rats.
  Q Mei, TO Mundinger, Åke Lernmark, GJ Jr. Taborsky
  (2002) Diabetes, 51 p.2997-3002
- Multiple sclerosis and type 1 diabetes: an unlikely alliance.
  Åke Lernmark
  (2002) The Lancet, 359 p.1450-1451
- The antibody response to bacteriophage is linked to the lymphopenia gene in congenic BioBreeding rats.
  L Clark, C Greenbaum, J Jiang, Åke Lernmark, H Ochs
  (2002) Pathogens and Disease, 32 p.205-209
- Genetic effects on age-dependent onset and islet cell autoantibody markers in type 1 diabetes.
  J Graham, WA Hagopian, I Kockum, LS Li, CB Sanjeevi, et al.
  (2002) Diabetes, 51 p.1346-1355
- Serum IgG to heat shock proteins and Porphyromonas gingivalis antigens in diabetic patients with periodontitis.
  TJ Sims, Åke Lernmark, LA Mancl, RE Schifferle, RC Page, et al.
  (2002) Journal of Clinical Periodontology, 29 p.551-562
- The combination of several polymorphic amino acid residues in the DQ alpha and DQ beta chains forms a domain structure pattern and is associated with insulin-dependent diabetes mellitus
  CB Sanjeevi, Mona Landin-Olsson, I Kockum, G Dahlquist, Åke Lernmark
  (2002) Annals of the New York Academy of Sciences, 958 p.362-375
- Type 1 diabetes-related autoantibodies are rare in Alaska native populations.
  J Mohatt, LK Gilliam, L Bekris, S Ebbesson, Åke Lernmark
  (2002) Circumpolar Health Supplements, 61 p.21-21
- Treatment outcome for IDDM patients in relation to glutamic acid decarboxylase autoantibodies and serum IgG to periodontal pathogens
  Tom J. Sims, Åke Lernmark, Todd Smith, Roy C. Page, G. Rutger Persson
  (2001) Journal of Clinical Periodontology, 28 p.550-557
- Low serum conditions for in vitro generation of human macrophages with macrophage colony stimulating factor
  Annette Plesner, Carla J Greenbaum, Åke Lernmark
  (2001) Journal of Immunological Methods, 249 p.53-61
- A novel monoclonal antibody specific for the N-terminal end of GAD65
  Christiane S Hampe, Per Lundgren, Terri L Daniels, Lisa P Hammerle, Santica M. Marcovina, et al.
  (2001) Journal of Neuroimmunology, 113 p.63-71
- Glucose-regulated insulin expression in diabetic rats
  S. C. Barry, N. Ramesh, D. V. Lejnieks, William T Simonson, L. Kemper, et al.
  (2001) Human Gene Therapy, 12 p.131-139
- Site-directed mutagenesis of K396R of the 65 kDa glutamic acid decarboxylase active site obliterates enzyme activity but not antibody binding
  Christiane S Hampe, Lisa P Hammerle, Alberto Falorni, John D. Robertson, Åke Lernmark
  (2001) FEBS Letters, 488 p.185-189
- Low-dose streptozotocin induces sustained hyperglycemia in Macaca nemestrina
  L K Gaur, Gerald T Nepom, Å Lernmark
  (2001) Autoimmunity, 33 p.103-114
- Prediction of diabetes with body mass index, oral glucose tolerance test and islet cell autoantibodies in a regional population
  O Rolandsson, E. Hägg, M. Nilsson, G Hallmans, Lucia Mincheva-Nilsson, et al.
  (2001) Journal of Internal Medicine1989-01-01+01:00, 249 p.279-288
- Preservation of enzyme activity and antigenicity after mutagenesis of the membrane anchoring domain of GAD65
  Annette Plesner, Christiane S Hampe, Terri L Daniels, Lisa P Hammerle, Åke Lernmark
  (2001) Autoimmunity, 34 p.221-230
- Combinations of beta cell specific autoantibodies at diagnosis of diabetes in young adults reflects different courses of beta cell damage
  Carina Törn, Mona Landin-Olsson, Åke Lernmark, Bengt Scherstén, J. Ostman, et al.
  (2001) Autoimmunity, 33 p.115-120
- Activated human epitope-specific T cells identified by class II tetramers reside within a CD4high, proliferating subset
  Erik J. Novak, Susan A. Masewicz, Andrew W. Liu, Åke Lernmark, William W. Kwok, et al.
  (2001) International Immunology, 13 p.799-806
- Prediction of silent celiac disease at diagnosis of childhood type 1 diabetes by tissue transglutaminase autoantibodies and HLA
  Daniel Agardh, Anita Ramelius, Tiinamaija Toumi, Bengt Lindberg, Anneli K Carlsson, et al.
  (2001) Pediatric Diabetes, 2 p.58-65
- Evaluation of a novel radioimmunoassay using ¹²⁵I-labelled human recombinant GAD65 for the determination of glutamic acid decarboxylase (GAD65) autoantibodies
  Santica M. Marcovina, M. Landin-Olsson, A. Essen-Möller, J. P. Palmer, Å Lernmark
  (2000) International Journal of Clinical and Laboratory Research, 30 p.21-26
- Alternative splicing of GAD67 results in the synthesis of a third form of glutamic-acid decarboxylase in human islets and other non-neural tissues
  Steven D. Chessler, Åke Lernmark
  (2000) Journal of Biological Chemistry, 275 p.5188-5192
- Rel B is an early marker of autoimmune islet inflammation in the BioBreeding (BB) rat
  Sabine Bieg, William T Simonson, Kristian Ellefsen, Åke Lernmark
  (2000) Pancreas, 20 p.47-54
- GAD65-specific autoantibodies enhance the presentation of an immunodominant T-cell epitope from GAD65
  Charlotta af Hällström-Reijonen, Terri L Daniels, A. Lernmark, Gerald T Nepom
  (2000) Diabetes, 49 p.1621-1626
- The length of the CTLA-4 microsatellite (AT)(N)-repeat affects the risk for type 1 diabetes
  Michael R. Lowe, J Graham, G. Sund, I Kockum, M. Landin-Olsson, et al.
  (2000) Autoimmunity, 32 p.173-180
- Recognition of glutamic acid decarboxylase (GAD) by autoantibodies from different GAD antibody-positive phenotypes
  Christiane S Hampe, Lisa P Hammerle, Lynn Bekris, Eva Örtqvist, Ingrid Kockum, et al.
  (2000) Journal of Clinical Endocrinology and Metabolism, 85 p.4671-4679
- Glutamic acid decarboxylase antibodies (GADA) is the most important factor for prediction of insulin therapy within 3 years in young adult diabetic patients not classified as Type 1 diabetes on clinical grounds
  Carina Törn, Mona Landin-Olsson, Jan Östman, Bengt Scherstén, Hans Arnqvist, et al.
  (2000) Diabetes/Metabolism Research and Reviews, 16 p.442-447
- Ketoacidosis in young adults is not related to the islet antibodies at the diagnosis of Type 1 diabetes mellitus - A nationwide study
  Jan Östman, M. Landin-Olsson, C. Törn, J. Palmer, A. Lernmark, et al.
  (2000) Diabetic Medicine, 17 p.269-274
- Antibodies to glutamic acid decarboxylase and peripheral nerve function in type 1 diabetes
  Robert D. Hoeldtke, Kimberly D. Bryner, Gerald R. Hobbs, Gabriella G. Horvath, Jack E. Riggs, et al.
  (2000) Journal of Clinical Endocrinology and Metabolism, 85 p.3297-3308
- The World Health Organization international collaborative study for islet cell antibodies
  A. R. Mire-Sluis, R Gaines Das, Å. Lernmark
  (2000) Diabetologia, 43 p.1282-1292
- Newly diagnosed latent autoimmune diabetes in adults (LADA) is associated with low level glutamate decarboxylase (GAD65) and IA-2 autoantibodies
  D. B. Schranz, L Bekris, M. Landin-Olsson, C. Törn, A. Niläng, et al.
  (2000) Hormone and Metabolic Research, 32 p.133-138
- Prognostic factors for the course of β cell function in autoimmune diabetes
  C. Törn, M. Landin-Olsson, Å Lernmark, J. P. Palmer, H. J. Arnqvist, et al.
  (2000) Journal of Clinical Endocrinology and Metabolism, 85 p.4619-4623
- Prevalence of β-cell and Thyroid Autoantibody Positivity in Schoolchildren during Three-Year Follow-up
  Bengt Lindberg, Annelie Carlsson, Ulla-Britt Ericsson, Ingrid Kockum, Åke Lernmark, et al.
  (1999) Autoimmunity, 31 p.175-185
- Inverse relationship between GAD65 antibody levels and severe retinopathy in younger type 1 diabetic patients
  Daniel Agardh, Elisabet Agardh, Mona Landin-Olsson, Lakshmi K Gaur, Carl-David Agardh, et al.
  (1998) Diabetes Research and Clinical Practice, 40 p.9-14
- Glutamate decarboxylase antibodies in non-diabetic pregnancy precedes insulin-dependent diabetes in the mother but not necessarily in the offspring
  Sten-A. Ivarsson, Malin Ackefors, Göran Ekberg, Alberto Falorni, Ingrid Kockum, et al.
  (1997) Autoimmunity, 26 p.261-269
- HLA-DQB1*0201/0302 is associated with severe retinopathy in patients with IDDM
  Daniel Agardh, L K Gaur, Elisabet Agardh, Mona Landin-Olsson, Carl-David Agardh, et al.
  (1996) Diabetologia, 39 p.1313-1317
Journal article (comment)
- The streetlight effect-is there light at the end of the tunnel?
  Åke Lernmark
  (2015) Diabetes, 64 p.1105-1107
- Depleting T cells in newly diagnosed autoimmune (type 1) diabetes--are we getting anywhere?
  Åke Lernmark
  (2013) Diabetes, 62 p.3669-3670
- Executive Summary: Guidelines and Recommendations for Laboratory Analysis in the Diagnosis and Management of Diabetes Mellitus
  David B. Sacks, Mark Arnold, George L. Bakris, David E. Bruns, Andrea Rita Horvath, et al.
  (2011) Clinical Chemistry, 57 p.793-798
- Molecular manipulation of autoantibody testing in type 1 diabetes : Two for one
  David B. Sacks, A. Lernmark
  (2001) Clinical Chemistry, 47 p.803-804
- Rapid-onset type 1 diabetes with pancreatic exocrine dysfunction
  A. Lernmark
  (2000) New England Journal of Medicine, 342 p.344-345
Journal article (letter)
- Genetic risk scores in adult-onset type 1 diabetes
  Richard David Leslie, Åke Lernmark
  (2018) The Lancet Diabetes and Endocrinology, 6 p.168-169
- The human gut microbiome in early-onset type 1 diabetes from the TEDDY study
  Tommi Vatanen, Eric A. Franzosa, Randall Schwager, Surya Tripathi, Timothy D. Arthur, et al.
  (2018) Nature, 562 p.589-594
- Temporal development of the gut microbiome in early childhood from the TEDDY study
  Christopher J. Stewart, Nadim J. Ajami, Jacqueline L. O’Brien, Diane S. Hutchinson, Daniel P. Smith, et al.
  (2018) Nature, 562 p.583-588
- BLUEPRINT to decode the epigenetic signature written in blood
  David Adams, Lucia Altucci, Stylianos E. Antonarakis, Juan Ballesteros, Stephan Beck, et al.
  (2012) Nature Biotechnology1996-01-01+01:00, 30 p.224-226
- Editorial Comment on type 1 diabetes and antigen-specific immunotherapy.
  Åke Lernmark, H E Larsson
  (2011) Journal of Internal Medicine1989-01-01+01:00, 270 p.132-135
- Comment on : Edghill et al. (2008) insulin mutation screening in 1,044 patients with diabetes: mutations in the ins gene are a common cause of neonatal diabetes but a rare cause of diabetes diagnosed in childhood or adulthood: diabetes 57:1034-1042, 2008
  Sten A. Ivarsson, Åke Lernmark
  (2008) Diabetes, 57 p.9-9
- The BioBreeding rat diabetes model is infected with Ljungan virus
  Bo Niklasson, T Hultman, R Kallies, M Niedrig, R. Nilsson, et al.
  (2007) Diabetologia, 50 p.1559-1560
- D6S265*15 marks a DRB1*15, DQB1*0602 haplotype associated with attenuated protection from type 1 diabetes mellitus.
  A M Valdes, G Thomson, J Graham, M Zarghami, B McNeney, et al.
  (2005) Diabetologia, 48 p.2540-2543
- Type 1 diabetes--does suppressing T cells increase insulin?
  Åke Lernmark
  (2005) New England Journal of Medicine, 352 p.2642-2644
- GAD65 antibody epitope patterns of type 1.5 diabetic patients are consistent with slow-onset autoimmune diabetes.
  Christiane S Hampe, Ingrid Kockum, Mona Landin-Olsson, Carina Törn, Eva Ortqvist, et al.
  (2002) Diabetes Care, 25 p.1481-1482
- Controlling the controls: GAD65 autoreactive T cells in type 1 diabetes.
  Åke Lernmark
  (2002) Journal of Clinical Investigation, 109 p.869-870
- Stability of disease-associated antibody titers in pregnant women with type 1 diabetes with or without residual β-cell function [2]
  Eva Nord, Lena Edwall, Christiane S Hampe, Lynn Bekris, Bengt E. Persson, et al.
  (2000) Diabetes Care, 23 p.1019-1021
Journal article review
- The Better Diabetes Diagnosis (BDD) study – A review of a nationwide prospective cohort study in Sweden
  M. Persson, C. Becker, H. Elding Larsson, Lernmark, G. Forsander, et al.
  (2018) Diabetes Research and Clinical Practice, 140 p.236-244
- Environmental factors in the etiology of type 1 diabetes, celiac disease, and narcolepsy
  Åke Lernmark
  (2016) Pediatric Diabetes, 17 p.65-72
- Diabetes at the crossroads: relevance of disease classification to pathophysiology and treatment.
  R David Leslie, Jerry Palmer, Nanette C Schloot, Åke Lernmark
  (2016) Diabetologia, 59 p.13-20
- Does immune-tolerance treatment with Alum-formulated GAD65 protect insulin-production in the pancreatic islet β cells?
  Helena Elding Larsson, Åke Lernmark
  (2011) Human Vaccines, 7 p.45-49
- Hepatic steatosis in type 1 diabetes
  Simon Regnell, Åke Lernmark
  (2011) Review of Diabetic Studies, 8 p.454-467
- Guidelines and recommendations for laboratory analysis in the diagnosis and management of diabetes mellitus
  David B. Sacks, Mark Arnold, George L. Bakris, David E. Bruns, Andrea Rita Horvath, et al.
  (2011) Diabetes Care, 34 p.61-99
- GAD65 Autoimmunity-Clinical Studies
  Raivo Uibo, Åke Lernmark
  (2008) Advances in Immunology, 100 p.39-78
- Genetic and perinatal factors as risk for childhood type 1 diabetes
  K Larsson, Helena Larsson, E Cederwall, K Kockum, Sture Sjöblad, et al.
  (2004) Diabetes/Metabolism Research Reviews, 20 p.429-437
- Gene and Cell-Replacement Therapy in the Treatment of Type 1 Diabetes : How High Must the Standards Be Set?
  Philippe A Halban, Steven E Kahn, Åke Lernmark, Christopher J. Rhodes
  (2001) Diabetes, 50 p.2181-2191
- Autoimmune diseases : Are markers ready for prediction?
  Åke Lernmark
  (2001) Journal of Clinical Investigation, 108 p.1091-1096
- Autoimmune type 1 diabetes : Resolved and unresolved issues
  Abner Louis Notkins, Åke Lernmark
  (2001) Journal of Clinical Investigation, 108 p.1247-1252

23 November 2016

Åke Lernmark

E-mail: ake [dot] lernmark [at] med [dot] lu [dot] se

Principal investigator

Diabetes and Celiac Unit

Telephone number:+46 40 39 19 01

Mobile number:+46 70 616 47 79

Room number:60:11:015

Visiting address:Jan Waldenströms gata 35, Malmö

Service point:33

Professor

EXODIAB: Excellence in Diabetes Research in Sweden

My profile in Lund University research portal

Lund University Diabetes Centre

Excellence of diabetes research in Sweden

Åke Lernmark

Immunogenetics of Type 1 Diabetes

Publications

Publications

Publications