WP6 - Moderate Obesity-related Diabetes (MOD) - mechanisms & pathways

WP leaders
 

Nils Wierup and Olga Göransson

Objectives

  • To identify targetable mechanisms and pathways underlying initiation and progression of MOD.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Press releases

Selected publications

  • Herzog K et al. Metabolic Effects of Gastric Bypass Surgery: Is It All About Calories? Diabetes 2020 https://pubmed.ncbi.nlm.nih.gov/32527768/
  • Lindqvist A et al. Ghrelin suppresses insulin secretion in human islets and type 2 diabetes patients have diminished islet ghrelin cell number and lower plasma ghrelin levels. Mol Cell Endocrinol 2020 https://pubmed.ncbi.nlm.nih.gov/32371087/
  • Negoita F et al. JUP/plakoglobin is regulated by salt-inducible kinase 2, and is required for insulin-induced signalling and glucose uptake in adipocytes. Cell Signal. 2020 https://pubmed.ncbi.nlm.nih.gov/32966883/
  • Axling U et al. Increased whole body energy expenditure and protection against diet-induced obesity in Cyp8b1-deficient mice is accompanied by altered adipose tissue features. Adipocyte. 2020 https://pubmed.ncbi.nlm.nih.gov/33016185/